UCSF

NAD-dependent Deacetylase Sirtuin 1, Human (67 Compounds)

Swissprot:
SIRT1_HUMAN
Stitch:
SIRT1_HUMAN
UniProt:
Q96EB6
ChEMBL:
CHEMBL4506
Reactome:
REACT_200780
REACT_200827
PDB:
SIRT1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 67 17 2 0
Binding ≤ 1μM 35 9 0 0

Reactome Network (2)

Reactome ID Description Species
REACT_200780 Regulation of HSF1-mediated heat shock response Homo sapiens
REACT_200827 SIRT1 negatively regulates rRNA Expression Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SIRT2_HUMAN Q8IXJ6 CHEMBL4462 NAD-dependent Deacetylase Sirtuin 2, Human 78 13 2 3
SIRT3_HUMAN Q9NTG7 CHEMBL4461 NAD-dependent Deacetylase Sirtuin 3, Human 2 1 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
SIRT1-1-E NAD-dependent Deacetylase Sirtuin 1 (cluster #1 Of 3), Eukaryotic 28 17 2 0
SIRT1-2-E NAD-dependent Deacetylase Sirtuin 1 (cluster #2 Of 3), Eukaryotic 36 0 0 0
SIRT1-3-E NAD-dependent Deacetylase Sirtuin 1 (cluster #3 Of 3), Eukaryotic 5 2 0 0
Uniprot Swissprot Chembl Description Number Shared
SIRT2_HUMAN Q8IXJ6 CHEMBL4462 NAD-dependent Deacetylase Sirtuin 2, Human 20
HST2_YEAST P53686 CHEMBL5933 NAD-dependent Deacetylase HST2, Yeast 4
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
SIRT3_HUMAN Q9NTG7 CHEMBL4461 NAD-dependent Deacetylase Sirtuin 3, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
KAPCA_BOVIN P00517 CHEMBL2654 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Bovin 1
KAPCB_BOVIN P05131 CHEMBL3279 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Bovin 1
KPCA_HUMAN P17252 CHEMBL299 Protein Kinase C Alpha, Human 1
KPCA_RAT P05696 CHEMBL2855 Protein Kinase C Alpha, Rat 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
KPCB_RAT P68403 CHEMBL3020 Protein Kinase C Beta, Rat 1
KPCD1_HUMAN Q15139 CHEMBL3863 Protein Kinase C Mu, Human 1
KPCD3_HUMAN O94806 CHEMBL2595 Protein Kinase C Nu, Human 1
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 1
KPCD_RAT P09215 CHEMBL3633 Protein Kinase C Delta, Rat 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
KPCE_RAT P09216 CHEMBL3424 Protein Kinase C Epsilon, Rat 1
KPCG_HUMAN P05129 CHEMBL2938 Protein Kinase C Gamma, Human 1
KPCG_RAT P63319 CHEMBL3604 Protein Kinase C Gamma, Rat 1
KPCI_HUMAN P41743 CHEMBL2598 Protein Kinase C Iota, Human 1
KPCL_HUMAN P24723 CHEMBL3616 Protein Kinase C Eta, Human 1
KPCL_RAT Q64617 CHEMBL3990 Protein Kinase C Eta, Rat 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KPCT_RAT Q9WTQ0 CHEMBL4563 Protein Kinase C Theta, Rat 1
KPCZ_HUMAN Q05513 CHEMBL3438 Protein Kinase C Zeta, Human 1
KPCZ_RAT P09217 CHEMBL5379 Protein Kinase C Zeta, Rat 1
KS6A3_HUMAN P51812 CHEMBL2345 Ribosomal Protein S6 Kinase Alpha 3, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1
MDHM_HUMAN P40926 CHEMBL5917 Malate Dehydrogenase, Mitochondrial, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1

Most Common Rings