UCSF

Norepinephrine Transporter, Human (2,711 Compounds)

Swissprot:
SC6A2_HUMAN
Stitch:
SC6A2_HUMAN
UniProt:
P23975
ChEMBL:
CHEMBL222
Reactome:
REACT_20506
PDB:
SLC6A2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,711 158 43 54
Binding ≤ 1μM 2,170 98 38 48
Functional ≤ 10μM 169 21 9 10

Reactome Network (1)

Reactome ID Description Species
REACT_20506 Na+/Cl- dependent neurotransmitter transporters Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1748
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 52 9 5 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SC6A1_HUMAN P30531 CHEMBL1903 GABA Transporter 1, Human 84 7 4 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2,208 143 41 50
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 4,112 205 45 56
SC6A5_HUMAN Q9Y345 CHEMBL3060 Glycine Transporter 2, Human 116 8 0 0
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 604 15 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
SC6A2-1-E Norepinephrine Transporter (cluster #1 Of 2), Eukaryotic 1,831 118 24 28
SC6A2-2-E Norepinephrine Transporter (cluster #2 Of 2), Eukaryotic 996 59 27 38
Uniprot Swissprot Chembl Description Number Shared
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2322
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1748
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 164
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 142
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 132
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 127
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 89
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 54
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 46
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 43
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 38
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 35
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 33
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 27
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 26
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 25
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 22
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 17
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 16
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 16
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 15
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 15
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 15
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 14
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 13
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 13
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 13
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 12
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 12
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 10
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 10
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 10
CASR_HUMAN P41180 CHEMBL1878 Calcium Sensing Receptor, Human 10
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 9
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 9
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 9
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 9
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 9
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 9
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 8
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 8
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 8
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 8
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 8
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 8
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 7
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 7
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 7
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 7
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 7
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 7
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 7
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 7
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 7
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 7
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 6
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 6
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 6
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 6
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 6
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 6
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 6
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 6
OPRX_RAT P35370 CHEMBL4503 Nociceptin Receptor, Rat 6
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 6
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 6
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 6
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 6
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 5
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 5
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 5
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 5
CCR3_MOUSE P51678 CHEMBL3406 C-C Chemokine Receptor Type 3, Mouse 5
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 5
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 5
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 4
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 4
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 4
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 4
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 4
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 4
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 4
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 4
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 4
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 4
CCR3_RAT O54814 CHEMBL3928 C-C Chemokine Receptor Type 3, Rat 4
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 4
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 4
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 4
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 4
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 3
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 3
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 3
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 3
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 3
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 3
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 3
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 3
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 3
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 3
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 3
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 3
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 3
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 3
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 3
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 3
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 3
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 3
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 3
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 3
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 2
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 2
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 2
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 2
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A3_MACFA Q9GJT6 CHEMBL5032 Dopamine Transporter, Macfa 2
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 2
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 2
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 2
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 1
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 1
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 1
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 1
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 1
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CASR_BOVIN P35384 CHEMBL1075316 Extracellular Calcium-sensing Receptor, Bovin 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
DYRK2_HUMAN Q92630 CHEMBL4376 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2, Human 1
DYRK3_HUMAN O43781 CHEMBL4575 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NMDZ1_RAT P35439 CHEMBL330 Glutamate (NMDA) Receptor Subunit Zeta 1, Rat 1
NORA_STAAU P0A0J7 CHEMBL5114 Quinolone Resistance Protein NorA, Staau 1
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 1
OPRM_MOUSE P42866 CHEMBL2858 Mu Opioid Receptor, Mouse 1
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1
SCN4A_HUMAN P35499 CHEMBL2072 Sodium Channel Protein Type IV Alpha Subunit, Human 1
SCN5A_HUMAN Q14524 CHEMBL1980 Sodium Channel Protein Type V Alpha Subunit, Human 1
SCN7A_HUMAN Q01118 CHEMBL3585 Sodium Channel Protein Type VII Alpha Subunit, Human 1
SCN9A_HUMAN Q15858 CHEMBL4296 Sodium Channel Protein Type IX Alpha Subunit, Human 1
SCNAA_HUMAN Q9Y5Y9 CHEMBL5451 Sodium Channel Protein Type X Alpha Subunit, Human 1
SCNBA_HUMAN Q9UI33 CHEMBL5167 Sodium Channel Protein Type XI Alpha Subunit, Human 1
SIRT1_HUMAN Q96EB6 CHEMBL4506 NAD-dependent Deacetylase Sirtuin 1, Human 1
SIRT2_HUMAN Q8IXJ6 CHEMBL4462 NAD-dependent Deacetylase Sirtuin 2, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
TSPOB_HUMAN B1AH88 CHEMBL5139 Peripheral-type Benzodiazepine Receptor, Human 1
Z100251 Z100251 CHEMBL612442 Monoclonal Antibody (mAb) 2E2 1
Z50591 Z50591 CHEMBL613489 Bos Taurus 1
Z50796 Z50796 CHEMBL614874 Monkey 1

Most Common Rings