UCSF

Prion Protein, Human (10 Compounds)

Swissprot:
PRIO_HUMAN
Stitch:
PRIO_HUMAN
UniProt:
P04156
ChEMBL:
CHEMBL4869
Reactome:
REACT_18312
PDB:
1E1G (DOCK)
1E1J (DOCK)
1E1P (DOCK)
1E1S (DOCK)
1E1U (DOCK)
1E1W (DOCK)
1FKC (DOCK)
1FO7 (DOCK)
1H0L (DOCK)
1HJM (DOCK)
1HJN (DOCK)
1I4M (DOCK)
1OEH (DOCK)
1OEI (DOCK)
1QLX (DOCK)
1QLZ (DOCK)
1QM0 (DOCK)
1QM1 (DOCK)
1QM2 (DOCK)
1QM3 (DOCK)
2IV4 (DOCK)
2IV5 (DOCK)
2IV6 (DOCK)
2K1D (DOCK)
2KUN (DOCK)
2LBG (DOCK)
2LEJ (DOCK)
2OL9 (DOCK)
2W9E (DOCK)
3HAF (DOCK)
3HAK (DOCK)
3HEQ (DOCK)
3HER (DOCK)
3HES (DOCK)
3HJ5 (DOCK)
3HJX (DOCK)
3MD4 (DOCK)
3MD5 (DOCK)
3NHC (DOCK)
3NHD (DOCK)
3NVF (DOCK)
PRNP

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 10 10 10 10
Binding ≤ 1μM 2 2 2 2

Reactome Network (1)

Reactome ID Description Species
REACT_18312 NCAM1 interactions Homo sapiens

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 7
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 7
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 7
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 7
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 4
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 3
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 3
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 3
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 3
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 3
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 2
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 2
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 2
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 2
CHLE_HORSE P81908 CHEMBL5763 Cholinesterase, Horse 2
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 2
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
HRP1_PLAFA P05227 CHEMBL1923 Histidine-rich Protein, Plafa 2
NQO2_HUMAN P16083 CHEMBL3959 Quinone Reductase 2, Human 2
Z100275 Z100275 CHEMBL613898 Hemozoin 2
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 2
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 1
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 1
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 1
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 1
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 1
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 1
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 1
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 1
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 1
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 1
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 1
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 1
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 1
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 1
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 1
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 1
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 1
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 1
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 1
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 1
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1