ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (47)
Reactome (9)
Related By:
Pathway (21)
Organism (2)
Gene (5)
Org. Clust. (1)
ChEMBL (102)
Rings (11)

Adenylate Cyclase Type II, Rat (47 Compounds)

Swissprot:: ADCY2_RAT
Stitch:: ADCY2_RAT
UniProt:: P26769
ChEMBL:: CHEMBL2958
Reactome:: REACT_254375; REACT_258389; REACT_233455; REACT_246814; REACT_247282; REACT_255871; REACT_234788; REACT_242357; REACT_259181
PDB:: 1AB8 (DOCK); 1AZS (DOCK); 1CJK (DOCK); 1CJT (DOCK); 1CJU (DOCK); 1CJV (DOCK); 1CS4 (DOCK); 1CUL (DOCK); 1TL7 (DOCK); 1U0H (DOCK); 2GVD (DOCK); 2GVZ (DOCK); 3C14 (DOCK); 3C15 (DOCK); 3C16 (DOCK); 3G82 (DOCK); 3MAA (DOCK); Adcy2

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	47	24	5	5
Binding ≤ 1μM	38	19	4	4
Functional ≤ 10μM	24	9	3	3

Reactome ID	Description	Species
REACT_254375	Adenylate cyclase activating pathway	Rattus norvegicus
REACT_258389	Adenylate cyclase inhibitory pathway	Rattus norvegicus
REACT_233455	G alpha (i) signalling events	Rattus norvegicus
REACT_246814	G alpha (s) signalling events	Rattus norvegicus
REACT_247282	G alpha (z) signalling events	Rattus norvegicus
REACT_255871	Glucagon signaling in metabolic regulation	Rattus norvegicus
REACT_234788	PKA activation	Rattus norvegicus
REACT_242357	PKA activation in glucagon signalling	Rattus norvegicus
REACT_259181	Vasopressin regulates renal water homeostasis via Aquaporins	Rattus norvegicus

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

Adenylate cyclase inhibitory pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

G alpha (i) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	27
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	4
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	3
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	3
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	20
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	4
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	3
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	1
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	1
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	1
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	22
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	1
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

G alpha (z) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	4
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	3
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	3
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

Glucagon signaling in metabolic regulation

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

PKA activation

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

PKA activation in glucagon signalling

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot	Swissprot	Chembl	Description	Number Shared
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	30	7	7	6
ADCY2_MOUSE	Q80TL1	CHEMBL3049	Adenylate Cyclase Type II, Mouse	2	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	36	24	5	5
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	36	24	5	5
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	62	29	5	6
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	36	24	5	5
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	36	24	5	5

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ADCY2-1-E	Adenylate Cyclase Type II (cluster #1 Of 2), Eukaryotic	23	11	3	2
ADCY2-2-E	Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic	57	21	9	9

Uniprot	Swissprot	Chembl	Description	Number Shared
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	40
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	40
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	40
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	40
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	40
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	26
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	22
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	20
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	20
AA1R_BOVIN	P28190	CHEMBL4975	Adenosine A1 Receptor, Bovin	16
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	13
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	11
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	11
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	10
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	9
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	9
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	9
AA2BR_HUMAN	P29275	CHEMBL255	Adenosine A2b Receptor, Human	8
AA3R_RAT	P28647	CHEMBL3360	Adenosine A3 Receptor, Rat	8
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	8
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	5
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	5
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	4
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	4
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	4
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	4
Z50512	Z50512	CHEMBL369	Cavia Porcellus	4
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	3
AA1R_CHICK	P49892	CHEMBL2114	Adenosine A1 Receptor, Chick	3
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	3
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	3
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	3
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	3
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	2
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	2
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	2
ADCY5_HUMAN	O95622	CHEMBL3189	Adenylate Cyclase Type V, Human	2
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	2
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	2
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
PDR5_YEAST	P33302	CHEMBL1697658	Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast	2
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	2
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	2
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	2
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	2
Z50587	Z50587	CHEMBL372	Homo Sapiens	2
Z80945	Z80945	CHEMBL614735	HEp-2 (Laryngeal Carcinoma Cells)	2
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	1
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	1
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	1
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	1
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	1
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	1
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	1
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	1
ANDR_RAT	P15207	CHEMBL3072	Androgen Receptor, Rat	1
CALM_HUMAN	P62158	CHEMBL6093	Calmodulin, Human	1
DRD1_MOUSE	Q61616	CHEMBL3071	Dopamine D1 Receptor, Mouse	1
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
MDR1_HUMAN	P08183	CHEMBL4302	P-glycoprotein 1, Human	1
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	1
MTR1B_HUMAN	P49286	CHEMBL1946	Melatonin Receptor 1B, Human	1
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	1
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	1
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	1
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	1
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	1
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	1
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	1
PRIO_HUMAN	P04156	CHEMBL4869	Prion Protein, Human	1
Q4VQ11_PIG	Q4VQ11	CHEMBL1075029	A1 Adenosine Receptor, Pig	1
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	1
S29A1_HUMAN	Q99808	CHEMBL1997	Equilibrative Nucleoside Transporter 1, Human	1
S29A1_RAT	O54698	CHEMBL4604	Equilibrative Nucleoside Transporter 1, Rat	1
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	1
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	1
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	1
SC6A4_MOUSE	Q60857	CHEMBL4642	Serotonin Transporter, Mouse	1
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	1
TRPV1_RAT	O35433	CHEMBL5102	Vanilloid Receptor, Rat	1
TYTR_TRYCR	P28593	CHEMBL5131	Trypanothione Reductase, Trycr	1
Z100499	Z100499	CHEMBL612575	SARS Coronavirus	1
Z101682	Z101682	CHEMBL613915	BK Polyomavirus	1
Z102380	Z102380	CHEMBL613680	Ileum	1
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	1
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	1
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	1
Z50588	Z50588	CHEMBL373	Canis Familiaris	1
Z50636	Z50636	CHEMBL613725	Sindbis Virus	1
Z80064	Z80064	CHEMBL382	CCRF-CEM (T-cell Leukemia)	1
Z80193	Z80193	CHEMBL386	L1210 (Lymphocytic Leukemia Cells)	1