UCSF

Adenylate Cyclase Type II, Mouse (2 Compounds)

Swissprot:
ADCY2_MOUSE
Stitch:
ADCY2_MOUSE
UniProt:
Q80TL1
ChEMBL:
CHEMBL3049
Reactome:
REACT_224974
REACT_222824
REACT_250376
REACT_242871
REACT_258013
REACT_210399
REACT_220108
REACT_220758
REACT_213947
PDB:
Adcy2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2 0 0 0
Binding ≤ 1μM 2 0 0 0

Reactome Network (9)

Reactome ID Description Species
REACT_224974 Adenylate cyclase activating pathway Mus musculus
REACT_222824 Adenylate cyclase inhibitory pathway Mus musculus
REACT_250376 G alpha (i) signalling events Mus musculus
REACT_242871 G alpha (s) signalling events Mus musculus
REACT_258013 G alpha (z) signalling events Mus musculus
REACT_210399 Glucagon signaling in metabolic regulation Mus musculus
REACT_220108 PKA activation Mus musculus
REACT_220758 PKA activation in glucagon signalling Mus musculus
REACT_213947 Vasopressin regulates renal water homeostasis via Aquaporins Mus musculus
Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

Adenylate cyclase inhibitory pathway

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

G alpha (z) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

PKA activation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

PKA activation in glucagon signalling

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot Swissprot Chembl Description Number Shared
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 30 7 7 6
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 47 24 5 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2 0 0 0
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2 0 0 0
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2 0 0 0
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2 0 0 0
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2 0 0 0
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2 0 0 0
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADCY2-1-E Adenylate Cyclase Type II (cluster #1 Of 2), Eukaryotic 23 11 3 2
ADCY2-2-E Adenylate Cyclase Type II (cluster #2 Of 2), Eukaryotic 57 21 9 9
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 2
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 2
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 2
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 2
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 2