| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 24 | 1 | 1 | 0 |
| Binding ≤ 1μM | 23 | 0 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_15312 | Adenylate cyclase activating pathway | Homo sapiens |
| REACT_15333 | Adenylate cyclase inhibitory pathway | Homo sapiens |
| REACT_20625 | CREB phosphorylation through the activation of Adenylate Cyclase | Homo sapiens |
| REACT_19231 | G alpha (i) signalling events | Homo sapiens |
| REACT_19327 | G alpha (s) signalling events | Homo sapiens |
| REACT_19333 | G alpha (z) signalling events | Homo sapiens |
| REACT_1665 | Glucagon signaling in metabolic regulation | Homo sapiens |
| REACT_15530 | PKA activation | Homo sapiens |
| REACT_1946 | PKA activation in glucagon signalling | Homo sapiens |
| REACT_24023 | Vasopressin regulates renal water homeostasis via Aquaporins | Homo sapiens |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| AA1R_HUMAN | P30542 | CHEMBL226 | Adenosine A1 Receptor, Human | 1 |
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| AA2AR_HUMAN | P29274 | CHEMBL251 | Adenosine A2a Receptor, Human | 1 |
| AA2BR_HUMAN | P29275 | CHEMBL255 | Adenosine A2b Receptor, Human | 1 |
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| GIPR_HUMAN | P48546 | CHEMBL4383 | Gastric Inhibitory Polypeptide Receptor, Human | 1 |
| GLP1R_HUMAN | P43220 | CHEMBL1784 | Glucagon-like Peptide Receptor, Human | 1 |
| GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ADCY3_MOUSE | Q8VHH7 | CHEMBL2920 | Adenylate Cyclase Type III, Mouse | 2 | 0 | 0 | 0 |
| ADCY3_RAT | P21932 | CHEMBL4864 | Adenylate Cyclase Type III, Rat | 36 | 24 | 5 | 5 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 75 | 8 | 8 | 7 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 30 | 7 | 7 | 6 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 | 0 | 0 | 0 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 46 | 3 | 1 | 0 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 | 1 | 1 | 0 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 | 1 | 1 | 0 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 30 | 7 | 7 | 6 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 | 1 | 1 | 0 |
| ADCYA_HUMAN | Q96PN6 | CHEMBL5854 | Adenylate Cyclase Type 10, Human | 5 | 4 | 1 | 1 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| ADCY3-1-E | Adenylate Cyclase Type III (cluster #1 Of 2), Eukaryotic | 12 | 11 | 3 | 2 |
| ADCY3-2-E | Adenylate Cyclase Type III (cluster #2 Of 2), Eukaryotic | 51 | 15 | 3 | 3 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ADCY1_HUMAN | Q08828 | CHEMBL2899 | Brain Adenylate Cyclase 1, Human | 24 |
| ADCY2_HUMAN | Q08462 | CHEMBL3760 | Adenylate Cyclase Type II, Human | 24 |
| ADCY5_HUMAN | O95622 | CHEMBL3189 | Adenylate Cyclase Type V, Human | 24 |
| ADCY6_HUMAN | O43306 | CHEMBL3221 | Adenylate Cyclase Type VI, Human | 24 |
| ADCY7_HUMAN | P51828 | CHEMBL4922 | Adenylate Cyclase Type VII, Human | 24 |
| ADCY8_HUMAN | P40145 | CHEMBL2960 | Adenylate Cyclase Type VIII, Human | 24 |
| ADCY9_HUMAN | O60503 | CHEMBL2655 | Adenylate Cyclase Type IX, Human | 24 |
| ADCY4_HUMAN | Q8NFM4 | CHEMBL2533 | Adenylate Cyclase Type IV, Human | 23 |
| GLR_HUMAN | P47871 | CHEMBL1985 | Glucagon Receptor, Human | 23 |
| ADCY1_MOUSE | O88444 | CHEMBL3532 | Adenylate Cyclase Type I, Mouse | 2 |
| ADCY2_MOUSE | Q80TL1 | CHEMBL3049 | Adenylate Cyclase Type II, Mouse | 2 |
| ADCY3_MOUSE | Q8VHH7 | CHEMBL2920 | Adenylate Cyclase Type III, Mouse | 2 |
| ADCY4_MOUSE | Q91WF3 | CHEMBL2556 | Adenylate Cyclase Type IV, Mouse | 2 |
| ADCY5_MOUSE | P84309 | CHEMBL2561 | Adenylate Cyclase Type V, Mouse | 2 |
| ADCY6_MOUSE | Q01341 | CHEMBL3015 | Adenylate Cyclase Type VI, Mouse | 2 |
| ADCY7_MOUSE | P51829 | CHEMBL3016 | Adenylate Cyclase Type VII, Mouse | 2 |
| ADCY8_MOUSE | P97490 | CHEMBL2961 | Adenylate Cyclase Type VIII, Mouse | 2 |
| AA1R_HUMAN | P30542 | CHEMBL226 | Adenosine A1 Receptor, Human | 1 |
| AA1R_RAT | P25099 | CHEMBL318 | Adenosine A1 Receptor, Rat | 1 |
| AA2AR_CAVPO | P46616 | CHEMBL2605 | Adenosine A2a Receptor, Guinea Pig | 1 |
| AA2AR_HUMAN | P29274 | CHEMBL251 | Adenosine A2a Receptor, Human | 1 |
| AA2AR_RAT | P30543 | CHEMBL302 | Adenosine A2a Receptor, Rat | 1 |
| AA2BR_HUMAN | P29275 | CHEMBL255 | Adenosine A2b Receptor, Human | 1 |
| AA2BR_RAT | P29276 | CHEMBL2592 | Adenosine A2b Receptor, Rat | 1 |
| GIPR_HUMAN | P48546 | CHEMBL4383 | Gastric Inhibitory Polypeptide Receptor, Human | 1 |
| GIPR_RAT | P43219 | CHEMBL5001 | Gastric Inhibitory Polypeptide Receptor, Rat | 1 |
| GLP1R_HUMAN | P43220 | CHEMBL1784 | Glucagon-like Peptide Receptor, Human | 1 |
| GLR_RAT | P30082 | CHEMBL4720 | Glucagon Receptor, Rat | 1 |