UCSF

Glucagon-like Peptide Receptor, Human (18 Compounds)

Swissprot:
GLP1R_HUMAN
Stitch:
GLP1R_HUMAN
UniProt:
P43220
ChEMBL:
CHEMBL1784
Reactome:
REACT_19327
REACT_18274
REACT_18377
PDB:
3C59 (DOCK)
3C5T (DOCK)
3IOL (DOCK)
GLP1R

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 18 1 0 0
Binding ≤ 1μM 11 1 0 0
Functional ≤ 10μM 33 1 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_18274 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Homo sapiens
REACT_18377 Glucagon-type ligand receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 6
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 6

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Uniprot Swissprot Chembl Description Number Shared
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1

Glucagon-type ligand receptors

Uniprot Swissprot Chembl Description Number Shared
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 6
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GLP1R_RAT P32301 CHEMBL5862 Glucagon-like Peptide 1 Receptor, Rat 0 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 6
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 6
GIPR_RAT P43219 CHEMBL5001 Gastric Inhibitory Polypeptide Receptor, Rat 2
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY4_HUMAN Q8NFM4 CHEMBL2533 Adenylate Cyclase Type IV, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1