UCSF

Adenylate Cyclase Type IV, Human (23 Compounds)

Swissprot:
ADCY4_HUMAN
Stitch:
ADCY4_HUMAN
UniProt:
Q8NFM4
ChEMBL:
CHEMBL2533
Reactome:
REACT_15312
REACT_15333
REACT_19231
REACT_19327
REACT_19333
REACT_1665
REACT_15530
REACT_1946
REACT_24023
PDB:
ADCY4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 23 0 0 0
Binding ≤ 1μM 23 0 0 0

Reactome Network (9)

Reactome ID Description Species
REACT_15312 Adenylate cyclase activating pathway Homo sapiens
REACT_15333 Adenylate cyclase inhibitory pathway Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_19333 G alpha (z) signalling events Homo sapiens
REACT_1665 Glucagon signaling in metabolic regulation Homo sapiens
REACT_15530 PKA activation Homo sapiens
REACT_1946 PKA activation in glucagon signalling Homo sapiens
REACT_24023 Vasopressin regulates renal water homeostasis via Aquaporins Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

Adenylate cyclase inhibitory pathway

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

G alpha (z) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23

PKA activation

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

PKA activation in glucagon signalling

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2 0 0 0
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 36 24 5 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 75 8 8 7
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 30 7 7 6
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 24 1 1 0
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 46 3 1 0
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 24 1 1 0
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 24 1 1 0
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 30 7 7 6
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 24 1 1 0
ADCYA_HUMAN Q96PN6 CHEMBL5854 Adenylate Cyclase Type 10, Human 5 4 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADCY4-1-E Adenylate Cyclase Type IV (cluster #1 Of 2), Eukaryotic 11 10 2 2
ADCY4-2-E Adenylate Cyclase Type IV (cluster #2 Of 2), Eukaryotic 51 15 3 3
Uniprot Swissprot Chembl Description Number Shared
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 23
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 23
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 23
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 23
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 23
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 23
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 23
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 23
GLR_HUMAN P47871 CHEMBL1985 Glucagon Receptor, Human 23
ADCY1_MOUSE O88444 CHEMBL3532 Adenylate Cyclase Type I, Mouse 2
ADCY2_MOUSE Q80TL1 CHEMBL3049 Adenylate Cyclase Type II, Mouse 2
ADCY3_MOUSE Q8VHH7 CHEMBL2920 Adenylate Cyclase Type III, Mouse 2
ADCY4_MOUSE Q91WF3 CHEMBL2556 Adenylate Cyclase Type IV, Mouse 2
ADCY5_MOUSE P84309 CHEMBL2561 Adenylate Cyclase Type V, Mouse 2
ADCY6_MOUSE Q01341 CHEMBL3015 Adenylate Cyclase Type VI, Mouse 2
ADCY7_MOUSE P51829 CHEMBL3016 Adenylate Cyclase Type VII, Mouse 2
ADCY8_MOUSE P97490 CHEMBL2961 Adenylate Cyclase Type VIII, Mouse 2
GIPR_HUMAN P48546 CHEMBL4383 Gastric Inhibitory Polypeptide Receptor, Human 1
GIPR_RAT P43219 CHEMBL5001 Gastric Inhibitory Polypeptide Receptor, Rat 1
GLP1R_HUMAN P43220 CHEMBL1784 Glucagon-like Peptide Receptor, Human 1
GLR_RAT P30082 CHEMBL4720 Glucagon Receptor, Rat 1