UCSF

Brain Adenylate Cyclase 1, Rat (8 Compounds)

Swissprot:
D4A3N4_RAT
Stitch:
D4A3N4_RAT
UniProt:
D4A3N4
ChEMBL:
CHEMBL2679
Reactome:
REACT_254375
REACT_258389
REACT_196394
REACT_233455
REACT_246814
REACT_247282
REACT_255871
REACT_234788
REACT_242357
REACT_259181

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 5 3 3
Binding ≤ 1μM 7 4 2 2
Functional ≤ 10μM 4 1 1 1

Reactome Network (10)

Reactome ID Description Species
REACT_254375 Adenylate cyclase activating pathway Rattus norvegicus
REACT_258389 Adenylate cyclase inhibitory pathway Rattus norvegicus
REACT_196394 CREB phosphorylation through the activation of Adenylate Cyclase Rattus norvegicus
REACT_233455 G alpha (i) signalling events Rattus norvegicus
REACT_246814 G alpha (s) signalling events Rattus norvegicus
REACT_247282 G alpha (z) signalling events Rattus norvegicus
REACT_255871 Glucagon signaling in metabolic regulation Rattus norvegicus
REACT_234788 PKA activation Rattus norvegicus
REACT_242357 PKA activation in glucagon signalling Rattus norvegicus
REACT_259181 Vasopressin regulates renal water homeostasis via Aquaporins Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

Adenylate cyclase inhibitory pathway

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 2
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 2
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 2
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 3
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 2
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 2
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

G alpha (z) signalling events

Uniprot Swissprot Chembl Description Number Shared
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 2
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 2
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 2
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

Glucagon signaling in metabolic regulation

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

PKA activation

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

PKA activation in glucagon signalling

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

Vasopressin regulates renal water homeostasis via Aquaporins

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 8
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 8
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 8
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 8
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 8
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 8
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 8
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 5
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 5
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 4
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 3
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 2
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 2
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 2
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 2
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 2
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 2
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 2
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 2
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 2
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 2
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 2
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 2
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 2
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 1
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 1
ANDR_RAT P15207 CHEMBL3072 Androgen Receptor, Rat 1
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 1
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 1
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 1
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 1
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 1
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
Z101682 Z101682 CHEMBL613915 BK Polyomavirus 1
Z102380 Z102380 CHEMBL613680 Ileum 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50636 Z50636 CHEMBL613725 Sindbis Virus 1