ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (279)
Reactome (2)
Related By:
Pathway (11)
Organism (3)
Gene (2)
Org. Clust. (1)
ChEMBL (120)
Rings (6)

Beta-1 Adrenergic Receptor, Rat (279 Compounds)

Swissprot:: ADRB1_RAT
Stitch:: ADRB1_RAT
UniProt:: P18090
ChEMBL:: CHEMBL3252
Reactome:: REACT_240632; REACT_246814
PDB:: 2FF9 (DOCK); Adrb1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	279	42	32	24
Binding ≤ 1μM	207	31	28	22
Functional ≤ 10μM	58	8	6	7

Reactome ID	Description	Species
REACT_240632	Adrenoceptors	Rattus norvegicus
REACT_246814	G alpha (s) signalling events	Rattus norvegicus

Uniprot	Swissprot	Chembl	Description	Number Shared
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	19
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	46
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	46
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	46
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	246

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT6R_RAT	P31388	CHEMBL3372	Serotonin 6 (5-HT6) Receptor, Rat	5
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	5
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	1
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	246
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	1
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB1_BOVIN	Q9TT96	CHEMBL2313	Beta-1 Adrenergic Receptor, Bovin	6	2	2	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	760	58	28	26
ADRB1_MOUSE	P34971	CHEMBL3440	Beta-1 Adrenergic Receptor, Mouse	16	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ADRB2_RAT	P10608	CHEMBL3754	Beta-2 Adrenergic Receptor, Rat	17	7	9	9
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	208	29	27	20

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
ADRB1-1-E	Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic	702	38	29	16
ADRB1-2-E	Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic	345	52	25	28

Uniprot	Swissprot	Chembl	Description	Number Shared
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	246
ADRB2_CANFA	P54833	CHEMBL2289	Beta-2 Adrenergic Receptor, Canine	222
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	54
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	46
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	46
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	46
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	30
ADRB2_BOVIN	Q28044	CHEMBL3373	Beta-2 Adrenergic Receptor, Bovin	27
ADRB2_RAT	P10608	CHEMBL3754	Beta-2 Adrenergic Receptor, Rat	26
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	24
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	22
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	20
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	19
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	19
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	19
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	18
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	18
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	18
ADRB2_CAVPO	Q8K4Z4	CHEMBL5414	Beta-2 Adrenergic Receptor, Guinea Pig	17
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	14
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	14
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	13
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	13
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	12
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	12
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	11
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	10
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	10
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	10
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	9
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	9
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	9
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	9
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	9
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	9
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	9
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	9
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	8
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	7
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	7
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	6
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	6
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	6
Z50512	Z50512	CHEMBL369	Cavia Porcellus	6
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) Receptor, Rat	5
5HT5A_RAT	P35364	CHEMBL4655	Serotonin 5a (5-HT5a) Receptor, Rat	5
5HT5B_RAT	P35365	CHEMBL2619	Serotonin 5b (5-HT5b) Receptor, Rat	5
5HT6R_RAT	P31388	CHEMBL3372	Serotonin 6 (5-HT6) Receptor, Rat	5
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	5
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	5
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	5
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	5
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	5
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	5
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	5
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	4
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	4
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	3
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	3
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	3
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	3
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	3
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ACM5_RAT	P08911	CHEMBL277	Muscarinic Acetylcholine Receptor M5, Rat	2
ADRB1_MOUSE	P34971	CHEMBL3440	Beta-1 Adrenergic Receptor, Mouse	2
ADRB2_MESAU	P04274	CHEMBL5943	Beta-2 Adrenergic Receptor, Mesau	2
ADRB2_MOUSE	P18762	CHEMBL3707	Beta-2 Adrenergic Receptor, Mouse	2
ADRB3_MOUSE	P25962	CHEMBL4030	Beta-3 Adrenergic Receptor, Mouse	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	2
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	2
FDFT_RAT	Q02769	CHEMBL3815	Squalene Synthetase, Rat	2
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	2
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	2
P97706_RAT	P97706	CHEMBL4957	Sodium Channel Protein Type VI Alpha Subunit, Rat	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SCN5A_RAT	P15389	CHEMBL3866	Sodium Channel Protein Type V Alpha Subunit, Rat	2
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z80088	Z80088	CHEMBL613853	CHO (Ovarian Cells)	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	1
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	1
5HT4R_CAVPO	O70528	CHEMBL5017	Serotonin 4 (5-HT4) Receptor, Guinea Pig	1
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	1
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	1
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	1
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	1
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	1
ACM3_RAT	P08483	CHEMBL320	Muscarinic Acetylcholine Receptor M3, Rat	1
ADA1A_RABIT	O02824	CHEMBL3637	Alpha-1a Adrenergic Receptor, Rabit	1
ADA1D_RABIT	O02666	CHEMBL4407	Alpha-1d Adrenergic Receptor, Rabit	1
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	1
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	1
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	1
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	1
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	1
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	1
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	1
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	1
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	1
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	1
HRH2_RAT	P25102	CHEMBL4654	Histamine H2 Receptor, Rat	1
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	1
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	1
MTR1B_HUMAN	P49286	CHEMBL1946	Melatonin Receptor 1B, Human	1
PRIO_HUMAN	P04156	CHEMBL4869	Prion Protein, Human	1
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	1
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	1
SC6A2_MOUSE	O55192	CHEMBL2370	Norepinephrine Transporter, Mouse	1
SC6A3_MOUSE	Q61327	CHEMBL2799	Dopamine Transporter, Mouse	1
SC6A4_MOUSE	Q60857	CHEMBL4642	Serotonin Transporter, Mouse	1
TYTR_TRYCR	P28593	CHEMBL5131	Trypanothione Reductase, Trycr	1