UCSF

Beta-1 Adrenergic Receptor, Rat (279 Compounds)

Swissprot:
ADRB1_RAT
Stitch:
ADRB1_RAT
UniProt:
P18090
ChEMBL:
CHEMBL3252
Reactome:
REACT_240632
REACT_246814
PDB:
2FF9 (DOCK)
Adrb1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 279 42 32 24
Binding ≤ 1μM 207 31 28 22
Functional ≤ 10μM 58 8 6 7

Reactome Network (2)

Reactome ID Description Species
REACT_240632 Adrenoceptors Rattus norvegicus
REACT_246814 G alpha (s) signalling events Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 19
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 46
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 46
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 46
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 246

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 5
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 5
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 246
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB1_BOVIN Q9TT96 CHEMBL2313 Beta-1 Adrenergic Receptor, Bovin 6 2 2 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 760 58 28 26
ADRB1_MOUSE P34971 CHEMBL3440 Beta-1 Adrenergic Receptor, Mouse 16 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 17 7 9 9
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 208 29 27 20

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADRB1-1-E Beta-1 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic 702 38 29 16
ADRB1-2-E Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic 345 52 25 28
Uniprot Swissprot Chembl Description Number Shared
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 246
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 222
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 54
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 46
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 46
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 46
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 30
ADRB2_BOVIN Q28044 CHEMBL3373 Beta-2 Adrenergic Receptor, Bovin 27
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 26
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 24
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 22
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 20
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 19
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 19
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 19
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 18
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 18
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 18
ADRB2_CAVPO Q8K4Z4 CHEMBL5414 Beta-2 Adrenergic Receptor, Guinea Pig 17
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 14
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 14
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 13
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 13
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 12
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 12
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 11
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 10
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 10
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 10
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 9
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 9
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 9
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 9
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 9
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 9
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 9
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 9
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 8
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 7
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 7
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 6
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 6
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 6
Z50512 Z50512 CHEMBL369 Cavia Porcellus 6
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 5
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 5
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 5
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 5
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 5
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 5
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 5
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 5
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 5
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 5
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 5
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 4
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 4
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 3
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 3
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 3
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 2
ADRB1_MOUSE P34971 CHEMBL3440 Beta-1 Adrenergic Receptor, Mouse 2
ADRB2_MESAU P04274 CHEMBL5943 Beta-2 Adrenergic Receptor, Mesau 2
ADRB2_MOUSE P18762 CHEMBL3707 Beta-2 Adrenergic Receptor, Mouse 2
ADRB3_MOUSE P25962 CHEMBL4030 Beta-3 Adrenergic Receptor, Mouse 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 2
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 2
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 2
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 2
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 1
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 1
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 1
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 1
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 1
ADA1A_RABIT O02824 CHEMBL3637 Alpha-1a Adrenergic Receptor, Rabit 1
ADA1D_RABIT O02666 CHEMBL4407 Alpha-1d Adrenergic Receptor, Rabit 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 1
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH3_CAVPO Q9JI35 CHEMBL5076 Histamine H3 Receptor, Guinea Pig 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 1
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 1
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1