ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (635)
Reactome (3)
Related By:
Pathway (0)
Organism (1)
Gene (0)
Org. Clust. (3)
ChEMBL (21)
Rings (11)

Squalene Synthetase, Rat (635 Compounds)

Swissprot:: FDFT_RAT
Stitch:: FDFT_RAT
UniProt:: Q02769
ChEMBL:: CHEMBL3815
Reactome:: REACT_198613; REACT_238041; REACT_196408
PDB:: Fdft1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	635	22	7	11
Binding ≤ 1μM	502	11	3	3

Reactome ID	Description	Species
REACT_198613	Activation of gene expression by SREBF (SREBP)	Rattus norvegicus
REACT_238041	Cholesterol biosynthesis	Rattus norvegicus
REACT_196408	PPARA activates gene expression	Rattus norvegicus

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
FDFT_HUMAN	P37268	CHEMBL3338	Squalene Synthetase, Human	299	5	1	5

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
FDFT-1-E	Squalene Synthetase (cluster #1 Of 4), Eukaryotic	668	13	4	10
FDFT-2-E	Squalene Synthetase (cluster #2 Of 4), Eukaryotic	26	1	1	2
FDFT-3-E	Squalene Synthetase (cluster #3 Of 4), Eukaryotic	135	5	1	1
FDFT-4-E	Squalene Synthetase (cluster #4 Of 4), Eukaryotic	56	8	2	2

Uniprot	Swissprot	Chembl	Description	Number Shared
FDFT_HUMAN	P37268	CHEMBL3338	Squalene Synthetase, Human	60
FNTA_BOVIN	P29702	CHEMBL2377	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin	12
FNTB_BOVIN	P49355	CHEMBL4671	Protein Farnesyltransferase Beta Subunit, Bovin	12
CRTM_STAAU	A9JQL9	CHEMBL5440	Dehydrosqualene Synthase, Staau	7
FNTA_HUMAN	P49354	CHEMBL271	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human	4
FNTB_HUMAN	P49356	CHEMBL272	Protein Farnesyltransferase Beta Subunit, Human	4
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	2
ADRB2_BOVIN	Q28044	CHEMBL3373	Beta-2 Adrenergic Receptor, Bovin	2
ADRB2_CANFA	P54833	CHEMBL2289	Beta-2 Adrenergic Receptor, Canine	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	2
GGPPS_HUMAN	O95749	CHEMBL4769	Geranylgeranyl Pyrophosphate Synthetase, Human	2
Q4CXF7_TRYCC	Q4CXF7	CHEMBL5220	Farnesyltransferase, Putative, Trycc	2
Q4Q5W4_LEIMA	Q4Q5W4	CHEMBL5223	Farnesyltransferase, Putative, Leima	2
FNTA_RAT	Q04631	CHEMBL4432	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat	1
FNTA_YEAST	P29703	CHEMBL2406	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Yeast	1
FNTB_RAT	Q02293	CHEMBL4890	Protein Farnesyltransferase Beta Subunit, Rat	1
FNTB_YEAST	P22007	CHEMBL4122	Protein Farnesyltransferase Beta Subunit, Yeast	1
FPPS_HUMAN	P14324	CHEMBL1782	Farnesyl Diphosphate Synthase, Human	1