UCSF

Geranylgeranyl Pyrophosphate Synthetase, Human (71 Compounds)

Swissprot:
GGPPS_HUMAN
Stitch:
GGPPS_HUMAN
UniProt:
O95749
ChEMBL:
CHEMBL4769
Reactome:
REACT_147904
REACT_9405
PDB:
2Q80 (DOCK)
GGPS1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 71 2 2 11
Binding ≤ 1μM 35 1 1 8

Reactome Network (2)

Reactome ID Description Species
REACT_147904 Activation of gene expression by SREBF (SREBP) Homo sapiens
REACT_9405 Cholesterol biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FDFT_HUMAN P37268 CHEMBL3338 Squalene Synthetase, Human 1
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 16

Cholesterol biosynthesis

Uniprot Swissprot Chembl Description Number Shared
FDFT_HUMAN P37268 CHEMBL3338 Squalene Synthetase, Human 1
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 16
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GGPPS_YEAST Q12051 CHEMBL1075251 Geranylgeranyl Pyrophosphate Synthase, Yeast 8 2 2 6

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
GGPPS-1-E Geranylgeranyl Pyrophosphate Synthase (cluster #1 Of 1), Eukaryotic 73 2 2 11
GGPPS-1-F Geranylgeranyl Pyrophosphate Synthase (cluster #1 Of 1), Fungal 8 2 2 6
Uniprot Swissprot Chembl Description Number Shared
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 16
GGPPS_YEAST Q12051 CHEMBL1075251 Geranylgeranyl Pyrophosphate Synthase, Yeast 8
Q0GKD7_LEIDO Q0GKD7 CHEMBL3693 Farnesyl Pyrophosphate Synthase, Leido 8
ISPA_ECOLI P22939 CHEMBL1075078 Geranyltranstransferase, Ecoli 3
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 2
Q8ST54_TRYCR Q8ST54 CHEMBL4151 Hexokinase, Trycr 2
FDFT_HUMAN P37268 CHEMBL3338 Squalene Synthetase, Human 1
Q8WS26_TRYCR Q8WS26 CHEMBL4752 Farnesyl Diphosphate Synthase, Trycr 1