UCSF

Squalene Synthetase, Human (299 Compounds)

Swissprot:
FDFT_HUMAN
Stitch:
FDFT_HUMAN
UniProt:
P37268
ChEMBL:
CHEMBL3338
Reactome:
REACT_147904
REACT_9405
REACT_116145
PDB:
1EZF (DOCK)
3ASX (DOCK)
3LEE (DOCK)
3Q2Z (DOCK)
3Q30 (DOCK)
FDFT1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 299 5 1 5
Binding ≤ 1μM 256 4 0 4
Functional ≤ 10μM 2 1 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_147904 Activation of gene expression by SREBF (SREBP) Homo sapiens
REACT_9405 Cholesterol biosynthesis Homo sapiens
REACT_116145 PPARA activates gene expression Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ERG1_HUMAN Q14534 CHEMBL3592 Squalene Monooxygenase, Human 2
ERG7_HUMAN P48449 CHEMBL3593 Lanosterol Synthase, Human 2
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 2
GGPPS_HUMAN O95749 CHEMBL4769 Geranylgeranyl Pyrophosphate Synthetase, Human 1

Cholesterol biosynthesis

Uniprot Swissprot Chembl Description Number Shared
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG1_HUMAN Q14534 CHEMBL3592 Squalene Monooxygenase, Human 2
ERG7_HUMAN P48449 CHEMBL3593 Lanosterol Synthase, Human 2
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 2
GGPPS_HUMAN O95749 CHEMBL4769 Geranylgeranyl Pyrophosphate Synthetase, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 635 22 7 11

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic 668 13 4 10
FDFT-2-E Squalene Synthetase (cluster #2 Of 4), Eukaryotic 26 1 1 2
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic 135 5 1 1
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic 56 8 2 2
Uniprot Swissprot Chembl Description Number Shared
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 60
CRTM_STAAU A9JQL9 CHEMBL5440 Dehydrosqualene Synthase, Staau 47
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 4
FNTB_HUMAN P49356 CHEMBL272 Protein Farnesyltransferase Beta Subunit, Human 4
Q4Q5W4_LEIMA Q4Q5W4 CHEMBL5223 Farnesyltransferase, Putative, Leima 4
ERG1_HUMAN Q14534 CHEMBL3592 Squalene Monooxygenase, Human 2
ERG7_HUMAN P48449 CHEMBL3593 Lanosterol Synthase, Human 2
FPPS_HUMAN P14324 CHEMBL1782 Farnesyl Diphosphate Synthase, Human 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
CYSP_TRYCR P25779 CHEMBL3563 Cruzipain, Trycr 1
DXR_ECOLI P45568 CHEMBL4091 1-deoxyxylulose-5-phosphate Reductoisomerase, Ecoli 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
FNTA_BOVIN P29702 CHEMBL2377 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin 1
FNTA_RAT Q04631 CHEMBL4432 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat 1
FNTB_BOVIN P49355 CHEMBL4671 Protein Farnesyltransferase Beta Subunit, Bovin 1
FNTB_RAT Q02293 CHEMBL4890 Protein Farnesyltransferase Beta Subunit, Rat 1
GGPPS_HUMAN O95749 CHEMBL4769 Geranylgeranyl Pyrophosphate Synthetase, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LEF_BACAN P15917 CHEMBL4372 Anthrax Lethal Factor, Bacan 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
Q6IE76_BOVIN Q6IE76 CHEMBL3605 Squalene Synthetase, Bovin 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
THA_HUMAN P10827 CHEMBL1860 Thyroid Hormone Receptor Alpha, Human 1
THB_HUMAN P10828 CHEMBL1947 Thyroid Hormone Receptor Beta-1, Human 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z81135 Z81135 CHEMBL614793 L6 (Skeletal Muscle Myoblast Cells) 1

Most Common Rings