ZINC 12

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Swissprot:: FNTB_RAT
Stitch:: FNTB_RAT
UniProt:: Q02293
ChEMBL:: CHEMBL4890
Reactome:: REACT_227662
PDB:: 1D8D (DOCK); 1D8E (DOCK); 1FPP (DOCK); 1FT1 (DOCK); 1FT2 (DOCK); 1FTI (DOCK); 1HZ7 (DOCK); 1JCR (DOCK); 1JCS (DOCK); 1KZO (DOCK); 1KZP (DOCK); 1KZR (DOCK); 1N94 (DOCK); 1N95 (DOCK); 1N9A (DOCK); 1NI1 (DOCK); 1NL4 (DOCK); 1O1R (DOCK); 1O1S (DOCK); 1O1T (DOCK); 1O5M (DOCK); 1QBQ (DOCK); 1QE2 (DOCK); 1SA5 (DOCK); 1TN7 (DOCK); 1TN8 (DOCK); 1X81 (DOCK); 2BED (DOCK); 2FTI (DOCK); 2R2L (DOCK); 2ZIR (DOCK); 2ZIS (DOCK); 3DPY (DOCK); 3E30 (DOCK); 3E32 (DOCK); 3E33 (DOCK); 3E34 (DOCK); 3EU5 (DOCK); 3EUV (DOCK); 3FTI (DOCK); 3KSL (DOCK); 3KSQ (DOCK); Fntb

Annotation Type	Substances	Purchasable	In Man
Binding ≤ 10μM	258	1	2
Binding ≤ 1μM	233	1	2
Functional ≤ 10μM	28	0	0

Reactome ID	Description	Species
REACT_227662	Inactivation, recovery and regulation of the phototransduction cascade	Rattus norvegicus

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
FNTB_BOVIN	P49355	CHEMBL4671	Protein Farnesyltransferase Beta Subunit, Bovin	649	6	4	5
FNTB_HUMAN	P49356	CHEMBL272	Protein Farnesyltransferase Beta Subunit, Human	1,846	10	4	5
FNTB_MOUSE	Q8K2I1	CHEMBL2631	Protein Farnesyltransferase Beta Subunit, Mouse	10	0	0	0
FNTB_YEAST	P22007	CHEMBL4122	Protein Farnesyltransferase Beta Subunit, Yeast	62	1	1	1

Code	Description	Substances	Purchasable	Natural	In Man
FNTB-1-E	Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic	2,600	12	6	7
FNTB-1-F	Protein Farnesyltransferase Beta Subunit (cluster #1 Of 2), Fungal	51	0	0	0
FNTB-2-E	Protein Farnesyltransferase Beta Subunit (cluster #2 Of 3), Eukaryotic	42	2	0	0
FNTB-2-F	Protein Farnesyltransferase Beta Subunit (cluster #2 Of 2), Fungal	11	1	1	1
FNTB-3-E	Protein Farnesyltransferase Beta Subunit (cluster #3 Of 3), Eukaryotic	52	0	1	0

Uniprot	Swissprot	Chembl	Description	Number Shared
FNTA_RAT	Q04631	CHEMBL4432	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat	282
FNTA_HUMAN	P49354	CHEMBL271	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human	77
FNTB_HUMAN	P49356	CHEMBL272	Protein Farnesyltransferase Beta Subunit, Human	75
Q5EI73_PLAFA	Q5EI73	CHEMBL4737	Protein Farnesyltransferase Alpha Subunit, Plafa	46
Q5EI74_PLAFA	Q5EI74	CHEMBL1741264	Protein Farnesyltransferase Beta Subunit, Plafa	46
PGTB1_HUMAN	P53609	CHEMBL4135	Geranylgeranyl Transferase Type I Beta Subunit, Human	41
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	22
RASH_HUMAN	P01112	CHEMBL2167	Transforming Protein P21/H-Ras-1, Human	7
FNTA_BOVIN	P29702	CHEMBL2377	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin	4
FNTB_BOVIN	P49355	CHEMBL4671	Protein Farnesyltransferase Beta Subunit, Bovin	4
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	4
Z80416	Z80416	CHEMBL614630	Rat1 (Fibroblast Cells)	3
FDFT_HUMAN	P37268	CHEMBL3338	Squalene Synthetase, Human	1
FDFT_RAT	Q02769	CHEMBL3815	Squalene Synthetase, Rat	1