ZINC 12

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Names
Compounds (40)
Reactome (28)
Related By:
Pathway (0)
Organism (0)
Gene (0)
Org. Clust. (0)
ChEMBL (18)
Rings (13)

Transforming Protein P21/H-Ras-1, Human (40 Compounds)

Swissprot:: RASH_HUMAN
Stitch:: RASH_HUMAN
UniProt:: P01112
ChEMBL:: CHEMBL2167
Reactome:: REACT_118778; REACT_147814; REACT_17025; REACT_121096; REACT_228085; REACT_163701; REACT_21247; REACT_12606; REACT_115854; REACT_23891; REACT_962; REACT_18334; REACT_12065; REACT_2077; REACT_614; REACT_20546; REACT_21374; REACT_661; REACT_12579; REACT_115993; REACT_116005; REACT_115852; REACT_121398; REACT_111040; REACT_12033; REACT_524; REACT_12621; REACT_228024
PDB:: 121P (DOCK); 1AA9 (DOCK); 1AGP (DOCK); 1BKD (DOCK); 1CLU (DOCK); 1CRP (DOCK); 1CRQ (DOCK); 1CRR (DOCK); 1CTQ (DOCK); 1GNP (DOCK); 1GNQ (DOCK); 1GNR (DOCK); 1HE8 (DOCK); 1IAQ (DOCK); 1IOZ (DOCK); 1JAH (DOCK); 1JAI (DOCK); 1K8R (DOCK); 1LF0 (DOCK); 1LF5 (DOCK); 1LFD (DOCK); 1NVU (DOCK); 1NVV (DOCK); 1NVW (DOCK); 1NVX (DOCK); 1P2S (DOCK); 1P2T (DOCK); 1P2U (DOCK); 1P2V (DOCK); 1PLJ (DOCK); 1PLK (DOCK); 1PLL (DOCK); 1Q21 (DOCK); 1QRA (DOCK); 1RVD (DOCK); 1WQ1 (DOCK); 1XCM (DOCK); 1XD2 (DOCK); 1XJ0 (DOCK); 1ZVQ (DOCK); 1ZW6 (DOCK); 221P (DOCK); 2C5L (DOCK); 2CE2 (DOCK); 2CL0 (DOCK); 2CL6 (DOCK); 2CL7 (DOCK); 2CLC (DOCK); 2CLD (DOCK); 2EVW (DOCK); 2GDP (DOCK); 2LCF (DOCK); 2Q21 (DOCK); 2QUZ (DOCK); 2RGA (DOCK); 2RGB (DOCK); 2RGC (DOCK); 2RGD (DOCK); 2RGE (DOCK); 2RGG (DOCK); 2UZI (DOCK); 2VH5 (DOCK); 2X1V (DOCK); 3DDC (DOCK); 3I3S (DOCK); 3K8Y (DOCK); 3K9L (DOCK); 3K9N (DOCK); 3KKM (DOCK); 3KKN (DOCK); 3KUD (DOCK); 3L8Y (DOCK); 3L8Z (DOCK); 3LBH (DOCK); 3LBI (DOCK); 3LBN (DOCK); 3LO5 (DOCK); 3OIU (DOCK); 3OIV (DOCK); 3OIW (DOCK); 3RRY (DOCK); 3RRZ (DOCK); 3RS0 (DOCK); 3RS2 (DOCK); 3RS3 (DOCK); 3RS4 (DOCK); 3RS5 (DOCK); 3RS7 (DOCK); 3RSL (DOCK); 3RSO (DOCK); 3TGP (DOCK); 421P (DOCK); 4Q21 (DOCK); 521P (DOCK); 5P21 (DOCK); 621P (DOCK); 6Q21 (DOCK); 721P (DOCK); 821P (DOCK); HRAS

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	40	1	1	1
Binding ≤ 1μM	18	1	1	1
Functional ≤ 10μM	16	0	0	1

Reactome ID	Description	Species
REACT_118778	Activation of RAS in B cells	Homo sapiens
REACT_147814	DAP12 signaling	Homo sapiens
REACT_17025	Downstream signal transduction	Homo sapiens
REACT_121096	EGFR Transactivation by Gastrin	Homo sapiens
REACT_228085	EPHB-mediated forward signaling	Homo sapiens
REACT_163701	FCERI mediated MAPK activation	Homo sapiens
REACT_21247	FRS2-mediated cascade	Homo sapiens
REACT_12606	GRB2 events in EGFR signaling	Homo sapiens
REACT_115854	GRB2 events in ERBB2 signaling	Homo sapiens
REACT_23891	Interleukin receptor SHC signaling	Homo sapiens
REACT_962	MEK activation	Homo sapiens
REACT_18334	NCAM signaling for neurite out-growth	Homo sapiens
REACT_12065	p38MAPK events	Homo sapiens
REACT_2077	RAF activation	Homo sapiens
REACT_614	RAF phosphorylates MEK	Homo sapiens
REACT_20546	Ras activation uopn Ca2+ infux through NMDA receptor	Homo sapiens
REACT_21374	SHC-mediated cascade	Homo sapiens
REACT_661	SHC-mediated signalling	Homo sapiens
REACT_12579	SHC1 events in EGFR signaling	Homo sapiens
REACT_115993	SHC1 events in ERBB2 signaling	Homo sapiens
REACT_116005	SHC1 events in ERBB4 signaling	Homo sapiens
REACT_115852	Signaling by constitutively active EGFR	Homo sapiens
REACT_121398	Signaling by FGFR mutants	Homo sapiens
REACT_111040	Signaling by SCF-KIT	Homo sapiens
REACT_12033	Signalling to RAS	Homo sapiens
REACT_524	SOS-mediated signalling	Homo sapiens
REACT_12621	Tie2 Signaling	Homo sapiens
REACT_228024	VEGFR2 mediated cell proliferation	Homo sapiens

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
FNTA_RAT	Q04631	CHEMBL4432	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat	7
FNTB_RAT	Q02293	CHEMBL4890	Protein Farnesyltransferase Beta Subunit, Rat	7
Q5EI73_PLAFA	Q5EI73	CHEMBL4737	Protein Farnesyltransferase Alpha Subunit, Plafa	7
Q5EI74_PLAFA	Q5EI74	CHEMBL1741264	Protein Farnesyltransferase Beta Subunit, Plafa	7
ESR1_HUMAN	P03372	CHEMBL206	Estrogen Receptor Alpha, Human	3
ESR2_HUMAN	Q92731	CHEMBL242	Estrogen Receptor Beta, Human	3
FNTA_HUMAN	P49354	CHEMBL271	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human	3
FNTB_HUMAN	P49356	CHEMBL272	Protein Farnesyltransferase Beta Subunit, Human	3
RAP1A_HUMAN	P62834	CHEMBL1255139	Ras-related Protein Rap-1A, Human	2
Z80951	Z80951	CHEMBL614822	NIH3T3 (Fibroblasts)	2
FNTA_MOUSE	Q61239	CHEMBL2153	Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Mouse	1
FNTB_MOUSE	Q8K2I1	CHEMBL2631	Protein Farnesyltransferase Beta Subunit, Mouse	1
TOP1_HUMAN	P11387	CHEMBL1781	DNA Topoisomerase I, Human	1
Z80106	Z80106	CHEMBL614563	COS-1 (Kidney Cells)	1
Z80224	Z80224	CHEMBL387	MCF7 (Breast Carcinoma Cells)	1
Z80928	Z80928	CHEMBL394	HCT-116 (Colon Carcinoma Cells)	1
Z81285	Z81285	CHEMBL615000	NIH-H Cell Line	1
Z81286	Z81286	CHEMBL615001	NIH-K Cell Line	1