UCSF

Protein Farnesyltransferase Beta Subunit, Human (1,846 Compounds)

Swissprot:
FNTB_HUMAN
Stitch:
FNTB_HUMAN
UniProt:
P49356
ChEMBL:
CHEMBL272
Reactome:
REACT_163919
PDB:
1JCQ (DOCK)
1LD7 (DOCK)
1LD8 (DOCK)
1MZC (DOCK)
1S63 (DOCK)
1SA4 (DOCK)
1TN6 (DOCK)
2F0Y (DOCK)
2H6F (DOCK)
2H6G (DOCK)
2H6H (DOCK)
2H6I (DOCK)
2IEJ (DOCK)
3E37 (DOCK)
FNTB

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,846 10 4 5
Binding ≤ 1μM 1,473 8 2 4
Functional ≤ 10μM 344 1 0 3

Reactome Network (1)

Reactome ID Description Species
REACT_163919 Inactivation, recovery and regulation of the phototransduction cascade Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 1971
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
FNTB_BOVIN P49355 CHEMBL4671 Protein Farnesyltransferase Beta Subunit, Bovin 649 6 4 5
FNTB_MOUSE Q8K2I1 CHEMBL2631 Protein Farnesyltransferase Beta Subunit, Mouse 10 0 0 0
FNTB_RAT Q02293 CHEMBL4890 Protein Farnesyltransferase Beta Subunit, Rat 258 1 0 2
FNTB_YEAST P22007 CHEMBL4122 Protein Farnesyltransferase Beta Subunit, Yeast 62 1 1 1

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
FNTB-1-E Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic 2,600 12 6 7
FNTB-1-F Protein Farnesyltransferase Beta Subunit (cluster #1 Of 2), Fungal 51 0 0 0
FNTB-2-E Protein Farnesyltransferase Beta Subunit (cluster #2 Of 3), Eukaryotic 42 2 0 0
FNTB-2-F Protein Farnesyltransferase Beta Subunit (cluster #2 Of 2), Fungal 11 1 1 1
FNTB-3-E Protein Farnesyltransferase Beta Subunit (cluster #3 Of 3), Eukaryotic 52 0 1 0
Uniprot Swissprot Chembl Description Number Shared
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 1971
PGTB1_HUMAN P53609 CHEMBL4135 Geranylgeranyl Transferase Type I Beta Subunit, Human 452
FNTA_RAT Q04631 CHEMBL4432 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat 83
FNTB_RAT Q02293 CHEMBL4890 Protein Farnesyltransferase Beta Subunit, Rat 75
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 62
FNTA_BOVIN P29702 CHEMBL2377 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Bovin 50
PGTB1_BOVIN Q5EAD5 CHEMBL4347 Geranylgeranyl Transferase Type I Beta Subunit, Bovin 35
FNTB_BOVIN P49355 CHEMBL4671 Protein Farnesyltransferase Beta Subunit, Bovin 31
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 31
Z80106 Z80106 CHEMBL614563 COS-1 (Kidney Cells) 23
FNTA_MOUSE Q61239 CHEMBL2153 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Mouse 12
FNTB_MOUSE Q8K2I1 CHEMBL2631 Protein Farnesyltransferase Beta Subunit, Mouse 12
Q5EI73_PLAFA Q5EI73 CHEMBL4737 Protein Farnesyltransferase Alpha Subunit, Plafa 12
Q5EI74_PLAFA Q5EI74 CHEMBL1741264 Protein Farnesyltransferase Beta Subunit, Plafa 12
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 8
Z81285 Z81285 CHEMBL615000 NIH-H Cell Line 8
FNTA_YEAST P29703 CHEMBL2406 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Yeast 7
FNTB_YEAST P22007 CHEMBL4122 Protein Farnesyltransferase Beta Subunit, Yeast 7
PGTB1_RAT P53610 CHEMBL3989 Geranylgeranyl Transferase Type I Beta Subunit, Rat 5
Z80401 Z80401 CHEMBL614241 PSN1 5
FDFT_HUMAN P37268 CHEMBL3338 Squalene Synthetase, Human 4
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 4
RASH_HUMAN P01112 CHEMBL2167 Transforming Protein P21/H-Ras-1, Human 3
FACE2_HUMAN Q9Y256 CHEMBL3411 Prenyl Protein Specific Protease, Human 2
ILVB_YEAST P07342 CHEMBL1075095 Acetolactate Synthase Catalytic Subunit, Mitochondrial, Yeast 1
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 1
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z81286 Z81286 CHEMBL615001 NIH-K Cell Line 1

Most Common Rings