UCSF
Image of Piperazine

Identity 99% 90% 80% 70% Substructure

Piperazine

PubMed — Wikipedia — Google

Ring Information

Rings Ring Systems Atoms Carbons Nitrogens Oxygens Sulfurs
1 1 6 4 2 0 0

Subset Information

Substances Natural Purchasable Annotated BB In Man Last Updated
View 348 211,611 1,425 20,389 19 2012-03-06

Most Common Targets

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 156 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 147 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 112 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 106 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 103 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 101 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 93 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 88 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 81 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 75 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 65 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 63 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 61 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 60 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 60 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 52 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 49 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 46 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 44 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 41 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 38 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 38 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 36 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 35 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 35 Annotations Catalogs SMILES SDF Mol2 Flexibase
P2Y12_HUMAN Q9H244 CHEMBL2001 Purinergic Receptor P2Y12, Human 35 Annotations Catalogs SMILES SDF Mol2 Flexibase
P2Y12_HUMAN Q9H244 CHEMBL2001 Purinergic Receptor P2Y12, Human 35 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1B_MESAU P18841 CHEMBL3122 Alpha-1b Adrenergic Receptor, Mesau 34 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1B_MESAU P18841 CHEMBL3122 Alpha-1b Adrenergic Receptor, Mesau 34 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 34 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 33 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 32 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 32 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 31 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 31 Annotations Catalogs SMILES SDF Mol2 Flexibase
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 31 Annotations Catalogs SMILES SDF Mol2 Flexibase
BKRB1_HUMAN P46663 CHEMBL4308 Bradykinin B1 Receptor, Human 31 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 29 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTB_HUMAN P49356 CHEMBL272 Protein Farnesyltransferase Beta Subunit, Human 29 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 29 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 29 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 28 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 28 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 28 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 25 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 25 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTB_HUMAN P49356 CHEMBL272 Protein Farnesyltransferase Beta Subunit, Human 25 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 25 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 24 Annotations Catalogs SMILES SDF Mol2 Flexibase
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 23 Annotations Catalogs SMILES SDF Mol2 Flexibase
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 23 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 23 Annotations Catalogs SMILES SDF Mol2 Flexibase
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 23 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 22 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACA_HUMAN Q13085 CHEMBL3351 Acetyl-CoA Carboxylase 1, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACA_HUMAN Q13085 CHEMBL3351 Acetyl-CoA Carboxylase 1, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
DCMC_HUMAN O95822 CHEMBL4698 Malonyl-CoA Decarboxylase, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
DCMC_HUMAN O95822 CHEMBL4698 Malonyl-CoA Decarboxylase, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
FNTB_HUMAN P49356 CHEMBL272 Protein Farnesyltransferase Beta Subunit, Human 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
CXCR3_HUMAN P49682 CHEMBL4441 C-X-C Chemokine Receptor Type 3, Human 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80036 Z80036 CHEMBL614524 BaF3 (IL-3-dependent Pro-B-cells) 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase