UCSF

FK506 Binding Protein 12, Human (912 Compounds)

Swissprot:
MTOR_HUMAN
Stitch:
MTOR_HUMAN
UniProt:
P42345
ChEMBL:
CHEMBL2842
Reactome:
REACT_19358
REACT_147727
REACT_200775
REACT_6838
REACT_75829
REACT_6836
REACT_6754
REACT_228016
PDB:
1AUE (DOCK)
1FAP (DOCK)
1NSG (DOCK)
2FAP (DOCK)
2GAQ (DOCK)
2NPU (DOCK)
3FAP (DOCK)
4FAP (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 912 27 2 6
Binding ≤ 1μM 732 20 1 3

Reactome Network (8)

Reactome ID Description Species
REACT_19358 CD28 dependent PI3K/Akt signaling Homo sapiens
REACT_147727 Constitutive PI3K/AKT Signaling in Cancer Homo sapiens
REACT_200775 HSF1-dependent transactivation Homo sapiens
REACT_6838 mTOR signalling Homo sapiens
REACT_75829 PIP3 activates AKT signaling Homo sapiens
REACT_6836 Release of eIF4E Homo sapiens
REACT_6754 S6K1-mediated signalling Homo sapiens
REACT_228016 VEGFR2 mediated vascular permeability Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 41
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 2
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 763

Constitutive PI3K/AKT Signaling in Cancer

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 41
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 99
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 2
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 763
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 162
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 192

PIP3 activates AKT signaling

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 41
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 99
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 4
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 2
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 763
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 162
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 192

S6K1-mediated signalling

Uniprot Swissprot Chembl Description Number Shared
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1

VEGFR2 mediated vascular permeability

Uniprot Swissprot Chembl Description Number Shared
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 41
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 58 2 0 0
MTOR_RAT P42346 CHEMBL1075134 Serine/threonine-protein Kinase MTOR, Rat 22 1 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MTOR-1-E Serine/threonine-protein Kinase MTOR (cluster #1 Of 3), Eukaryotic 22 5 1 1
MTOR-2-E Serine/threonine-protein Kinase MTOR (cluster #2 Of 3), Eukaryotic 899 22 1 5
MTOR-3-E Serine/threonine-protein Kinase MTOR (cluster #3 Of 3), Eukaryotic 51 2 0 0
Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 763
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 333
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 192
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 162
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 157
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 138
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 136
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 130
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 112
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 104
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 99
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 69
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 41
FKB14_HUMAN Q9NWM8 CHEMBL2342 FK506 Binding Protein 14, Human 27
FKBP3_HUMAN Q00688 CHEMBL4746 FK506 Binding Protein 3, Human 27
FKBP4_HUMAN Q02790 CHEMBL4050 FK506 Binding Protein 4, Human 27
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 19
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 6
FKB1A_HUMAN P62942 CHEMBL1902 FK506-binding Protein 1A, Human 5
FKB1B_HUMAN P68106 CHEMBL2430 FK506-binding Protein 1B, Human 4
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 4
Q9BJF5_TOXGO Q9BJF5 CHEMBL1781862 Calmodulin-domain Protein Kinase 1, Toxgo 4
PK3C3_HUMAN Q8NEB9 CHEMBL1075165 Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human 3
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 3
ATR_HUMAN Q13535 CHEMBL5024 Serine-protein Kinase ATR, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 2
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 2
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 2
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 2
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 2
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 2
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
ATM_HUMAN Q13315 CHEMBL3797 Serine-protein Kinase ATM, Human 1
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 1
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 1
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 1
CCNE1_HUMAN P24864 CHEMBL3617 G1/S-specific Cyclin E1, Human 1
CCNE2_HUMAN O96020 CHEMBL2884 G1/S-specific Cyclin E2, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KAPCA_HUMAN P17612 CHEMBL4101 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 1
KAPCB_HUMAN P22694 CHEMBL2918 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 1
KAPCG_HUMAN P22612 CHEMBL2743 CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human 1
KCC2A_MOUSE P11798 CHEMBL3347 CaM Kinase II Alpha, Mouse 1
KCC2B_MOUSE P28652 CHEMBL4735 CaM Kinase II Beta, Mouse 1
KCC2G_MOUSE Q923T9 CHEMBL4456 CaM Kinase II Gamma, Mouse 1
KS6B1_HUMAN P23443 CHEMBL4501 Ribosomal Protein S6 Kinase 1, Human 1
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MYLK_CHICK P11799 CHEMBL3062 Myosin Light Chain Kinase, Smooth Muscle, Chick 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_MOUSE P42337 CHEMBL2499 PI3-kinase P110-alpha Subunit, Mouse 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
RON_HUMAN Q04912 CHEMBL2689 Macrophage-stimulating Protein Receptor, Human 1
ROS1_HUMAN P08922 CHEMBL5568 Proto-oncogene Tyrosine-protein Kinase ROS, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1

Most Common Rings