UCSF

Breakpoint Cluster Region Protein, Human (92 Compounds)

Swissprot:
BCR_HUMAN
Stitch:
BCR_HUMAN
UniProt:
P11274
ChEMBL:
CHEMBL5146
Reactome:
REACT_11051
REACT_121141
PDB:
1K1F (DOCK)
2AIN (DOCK)
BCR

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 92 8 4 6
Binding ≤ 1μM 64 7 4 6
Functional ≤ 10μM 16 3 3 1

Reactome Network (2)

Reactome ID Description Species
REACT_11051 Rho GTPase cycle Homo sapiens
REACT_121141 Signaling by FGFR1 fusion mutants Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 106
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 14
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 8
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 6
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 6
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 5
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 5
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 5
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 5
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 5
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 4
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 4
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 4
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 4
NPM_HUMAN P06748 CHEMBL5178 Nucleophosmin, Human 4
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 4
A1Z199_HUMAN A1Z199 CHEMBL6105 BCR/ABL P210 Fusion Protein, Human 3
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 3
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 3
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 3
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 3
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 3
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 3
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 3
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 3
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 3
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 3
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 3
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 3
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 2
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 2
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 2
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 2
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 2
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 2
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 2
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 2
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 2
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 2
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 2
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 2
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 2
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 2
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 2
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 2
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 2
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 2
LCK_MOUSE P06240 CHEMBL2480 Tyrosine-protein Kinase LCK, Mouse 2
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 2
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 2
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 2
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 2
PGFRA_RAT P20786 CHEMBL2513 Platelet-derived Growth Factor Receptor Alpha, Rat 2
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 2
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 2
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 2
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 2
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 2
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 2
Z80036 Z80036 CHEMBL614524 BaF3 (IL-3-dependent Pro-B-cells) 2
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 2
Z80957 Z80957 CHEMBL614734 HMEC (Microvascular Endothelial Cells) 2
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 2
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 2
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 1
ABL1_MOUSE P00520 CHEMBL3099 Tyrosine-protein Kinase ABL, Mouse 1
ABL2_MOUSE Q4JIM5 CHEMBL5222 Tyrosine-protein Kinase ABL2, Mouse 1
ABL_MLVAB P00521 CHEMBL5166 Tyrosine-protein Kinase V-ABL, Mlvab 1
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 1
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 1
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 1
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CDK19_HUMAN Q9BWU1 CHEMBL6002 Cell Division Cycle 2-like Protein Kinase 6, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 1
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 1
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 1
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 1
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 1
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FAK2_HUMAN Q14289 CHEMBL5469 Protein Tyrosine Kinase 2 Beta, Human 1
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 1
FES_HUMAN P07332 CHEMBL5455 Tyrosine-protein Kinase FES, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
IRAK4_HUMAN Q9NWZ3 CHEMBL3778 Interleukin-1 Receptor-associated Kinase 4, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 1
KCC1D_HUMAN Q8IU85 CHEMBL5073 CaM Kinase I Delta, Human 1
KCC2G_HUMAN Q13555 CHEMBL3829 CaM Kinase II Gamma, Human 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 1
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 1
M4K2_HUMAN Q12851 CHEMBL5330 Mitogen-activated Protein Kinase Kinase Kinase Kinase 2, Human 1
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MELK_HUMAN Q14680 CHEMBL4578 Maternal Embryonic Leucine Zipper Kinase, Human 1
MINK1_HUMAN Q8N4C8 CHEMBL5518 Misshapen-like Kinase 1, Human 1
MK08_HUMAN P45983 CHEMBL2276 C-Jun N-terminal Kinase 1, Human 1
MK09_HUMAN P45984 CHEMBL4179 C-Jun N-terminal Kinase 2, Human 1
MK10_HUMAN P53779 CHEMBL2637 C-Jun N-terminal Kinase 3, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 1
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 1
PGFRB_MOUSE P05622 CHEMBL2749 Platelet-derived Growth Factor Receptor Beta, Mouse 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PLK4_HUMAN O00444 CHEMBL3788 Serine/threonine-protein Kinase PLK4, Human 1
PMYT1_HUMAN Q99640 CHEMBL3984 Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human 1
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 1
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 1
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
STK24_HUMAN Q9Y6E0 CHEMBL5082 Serine/threonine-protein Kinase 24, Human 1
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 1
STK4_HUMAN Q13043 CHEMBL4598 Serine/threonine-protein Kinase MST1, Human 1
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 1
TBK1_HUMAN Q9UHD2 CHEMBL5408 Serine/threonine-protein Kinase TBK1, Human 1
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 1
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 1
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 1
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1

Most Common Rings