ZINC 12

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Names
Compounds (1,234)
Reactome (29)
Related By:
Pathway (30)
Organism (2)
Gene (0)
Org. Clust. (1)
ChEMBL (110)
Rings (50)

PI3-kinase P110-alpha Subunit, Human (1,234 Compounds)

Swissprot:: PK3CA_HUMAN
Stitch:: PK3CA_HUMAN
UniProt:: P42336
ChEMBL:: CHEMBL4005
Reactome:: REACT_19358; REACT_147727; REACT_19344; REACT_147814; REACT_17025; REACT_12555; REACT_18407; REACT_18283; REACT_12578; REACT_1695; REACT_23891; REACT_23837; REACT_23832; REACT_21270; REACT_976; REACT_116008; REACT_115961; REACT_12464; REACT_75829; REACT_23787; REACT_163769; REACT_160158; REACT_115852; REACT_121398; REACT_121141; REACT_111040; REACT_121025; REACT_12621; REACT_228166
PDB:: 2ENQ (DOCK); 2RD0 (DOCK); 3HHM (DOCK); 3HIZ (DOCK); PIK3CA

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,234	42	4	9
Binding ≤ 1μM	934	31	3	7

Reactome ID	Description	Species
REACT_19358	CD28 dependent PI3K/Akt signaling	Homo sapiens
REACT_147727	Constitutive PI3K/AKT Signaling in Cancer	Homo sapiens
REACT_19344	Costimulation by the CD28 family	Homo sapiens
REACT_147814	DAP12 signaling	Homo sapiens
REACT_17025	Downstream signal transduction	Homo sapiens
REACT_12555	Downstream TCR signaling	Homo sapiens
REACT_18407	G alpha (12/13) signalling events	Homo sapiens
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_12578	GAB1 signalosome	Homo sapiens
REACT_1695	GPVI-mediated activation cascade	Homo sapiens
REACT_23891	Interleukin receptor SHC signaling	Homo sapiens
REACT_23837	Interleukin-3, 5 and GM-CSF signaling	Homo sapiens
REACT_23832	Nephrin interactions	Homo sapiens
REACT_21270	PI-3K cascade	Homo sapiens
REACT_976	PI3K Cascade	Homo sapiens
REACT_116008	PI3K events in ERBB2 signaling	Homo sapiens
REACT_115961	PI3K events in ERBB4 signaling	Homo sapiens
REACT_12464	PI3K/AKT activation	Homo sapiens
REACT_75829	PIP3 activates AKT signaling	Homo sapiens
REACT_23787	Regulation of signaling by CBL	Homo sapiens
REACT_163769	Role of LAT2/NTAL/LAB on calcium mobilization	Homo sapiens
REACT_160158	Role of phospholipids in phagocytosis	Homo sapiens
REACT_115852	Signaling by constitutively active EGFR	Homo sapiens
REACT_121398	Signaling by FGFR mutants	Homo sapiens
REACT_121141	Signaling by FGFR1 fusion mutants	Homo sapiens
REACT_111040	Signaling by SCF-KIT	Homo sapiens
REACT_121025	Synthesis of PIPs at the plasma membrane	Homo sapiens
REACT_12621	Tie2 Signaling	Homo sapiens
REACT_228166	VEGFA-VEGFR2 Pathway	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	43
MTOR_HUMAN	P42345	CHEMBL2842	FK506 Binding Protein 12, Human	763
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14

Constitutive PI3K/AKT Signaling in Cancer

Uniprot	Swissprot	Chembl	Description	Number Shared
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	43
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
GSK3A_HUMAN	P49840	CHEMBL2850	Glycogen Synthase Kinase-3 Alpha, Human	1
GSK3B_HUMAN	P49841	CHEMBL262	Glycogen Synthase Kinase-3 Beta, Human	2
MTOR_HUMAN	P42345	CHEMBL2842	FK506 Binding Protein 12, Human	763
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310

Costimulation by the CD28 family

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14

DAP12 signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

Downstream signal transduction

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

Downstream TCR signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

G alpha (12/13) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14

G alpha (q) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14

GAB1 signalosome

Uniprot	Swissprot	Chembl	Description	Number Shared
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

GPVI-mediated activation cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	43
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CG_HUMAN	P48736	CHEMBL3267	PI3-kinase P110-gamma Subunit, Human	492

Interleukin receptor SHC signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310

Interleukin-3, 5 and GM-CSF signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
KAPCA_HUMAN	P17612	CHEMBL4101	CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human	1
KAPCB_HUMAN	P22694	CHEMBL2918	CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human	1
KAPCG_HUMAN	P22612	CHEMBL2743	CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310

Nephrin interactions

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

PI-3K cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

PI3K Cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3C3_HUMAN	Q8NEB9	CHEMBL1075165	Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human	4
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

PI3K events in ERBB2 signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

PI3K events in ERBB4 signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

PI3K/AKT activation

Uniprot	Swissprot	Chembl	Description	Number Shared
NTRK1_HUMAN	P04629	CHEMBL2815	Nerve Growth Factor Receptor Trk-A, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

PIP3 activates AKT signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	43
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
MTOR_HUMAN	P42345	CHEMBL2842	FK506 Binding Protein 12, Human	763
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310

Regulation of signaling by CBL

Uniprot	Swissprot	Chembl	Description	Number Shared
HCK_HUMAN	P08631	CHEMBL3234	Tyrosine-protein Kinase HCK, Human	150
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310

Role of LAT2/NTAL/LAB on calcium mobilization

Uniprot	Swissprot	Chembl	Description	Number Shared
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

Role of phospholipids in phagocytosis

Uniprot	Swissprot	Chembl	Description	Number Shared
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273

Signaling by constitutively active EGFR

Uniprot	Swissprot	Chembl	Description	Number Shared
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

Signaling by FGFR mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

Signaling by FGFR1 fusion mutants

Uniprot	Swissprot	Chembl	Description	Number Shared
BCR_HUMAN	P11274	CHEMBL5146	Breakpoint Cluster Region Protein, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18

Signaling by SCF-KIT

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14

Synthesis of PIPs at the plasma membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
P3C2A_HUMAN	O00443	CHEMBL1075102	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human	3
P3C2B_HUMAN	O00750	CHEMBL5554	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human	9
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310
PK3CG_HUMAN	P48736	CHEMBL3267	PI3-kinase P110-gamma Subunit, Human	492

Tie2 Signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
TIE2_HUMAN	Q02763	CHEMBL4128	Tyrosine-protein Kinase TIE-2, Human	1

VEGFA-VEGFR2 Pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
KAPCA_HUMAN	P17612	CHEMBL4101	CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human	1
KAPCB_HUMAN	P22694	CHEMBL2918	CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human	1
KAPCG_HUMAN	P22612	CHEMBL2743	CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human	1
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	1
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
VGFR2_HUMAN	P35968	CHEMBL279	Vascular Endothelial Growth Factor Receptor 2, Human	118

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PK3CA_BOVIN	P32871	CHEMBL2498	PI3-kinase P110-alpha Subunit, Bovin	33	6	1	1
PK3CA_MOUSE	P42337	CHEMBL2499	PI3-kinase P110-alpha Subunit, Mouse	3	3	2	1

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
PK3CA-1-E	PI3-kinase P110-alpha Subunit (cluster #1 Of 2), Eukaryotic	12	0	0	0
PK3CA-2-E	PI3-kinase P110-alpha Subunit (cluster #2 Of 2), Eukaryotic	1,257	47	5	9

Uniprot	Swissprot	Chembl	Description	Number Shared
MTOR_HUMAN	P42345	CHEMBL2842	FK506 Binding Protein 12, Human	763
PK3CG_HUMAN	P48736	CHEMBL3267	PI3-kinase P110-gamma Subunit, Human	492
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	310
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	273
PRKDC_HUMAN	P78527	CHEMBL3142	DNA-dependent Protein Kinase, Human	197
HCK_HUMAN	P08631	CHEMBL3234	Tyrosine-protein Kinase HCK, Human	150
SRC_HUMAN	P12931	CHEMBL267	Tyrosine-protein Kinase SRC, Human	147
ABL1_HUMAN	P00519	CHEMBL1862	Tyrosine-protein Kinase ABL, Human	142
VGFR2_HUMAN	P35968	CHEMBL279	Vascular Endothelial Growth Factor Receptor 2, Human	118
EPHB4_HUMAN	P54760	CHEMBL5147	Ephrin Type-B Receptor 4, Human	111
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	110
PI4KB_HUMAN	Q9UBF8	CHEMBL3268	PI4-kinase Beta Subunit, Human	75
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	43
MTOR_MOUSE	Q9JLN9	CHEMBL1255165	Serine/threonine-protein Kinase MTOR, Mouse	21
MTOR_RAT	P42346	CHEMBL1075134	Serine/threonine-protein Kinase MTOR, Rat	19
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	18
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	14
P3C2B_HUMAN	O00750	CHEMBL5554	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human	9
Q9BJF5_TOXGO	Q9BJF5	CHEMBL1781862	Calmodulin-domain Protein Kinase 1, Toxgo	6
PDK1_HUMAN	Q15118	CHEMBL4766	Pyruvate Dehydrogenase Kinase Isoform 1, Human	4
PK3C3_HUMAN	Q8NEB9	CHEMBL1075165	Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human	4
PK3CA_BOVIN	P32871	CHEMBL2498	PI3-kinase P110-alpha Subunit, Bovin	4
P3C2A_HUMAN	O00443	CHEMBL1075102	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human	3
ATR_HUMAN	Q13535	CHEMBL5024	Serine-protein Kinase ATR, Human	2
CSK21_HUMAN	P68400	CHEMBL3629	Casein Kinase II Alpha, Human	2
CSK2B_HUMAN	P67870	CHEMBL2358	Casein Kinase II Beta, Human	2
GSK3B_HUMAN	P49841	CHEMBL262	Glycogen Synthase Kinase-3 Beta, Human	2
MRCKA_HUMAN	Q5VT25	CHEMBL4516	Serine/threonine-protein Kinase MRCK-A, Human	2
MYLK_HUMAN	Q15746	CHEMBL2428	Myosin Light Chain Kinase, Smooth Muscle, Human	2
PIM1_HUMAN	P11309	CHEMBL2147	Serine/threonine-protein Kinase PIM1, Human	2
PLK1_HUMAN	P53350	CHEMBL3024	Serine/threonine-protein Kinase PLK1, Human	2
PLK3_HUMAN	Q9H4B4	CHEMBL4897	Serine/threonine-protein Kinase PLK3, Human	2
RAF1_HUMAN	P04049	CHEMBL1906	Serine/threonine-protein Kinase RAF, Human	2
5NTD_RAT	P21588	CHEMBL1075214	5'-nucleotidase, Rat	1
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	1
ABCG2_HUMAN	Q9UNQ0	CHEMBL5393	ATP-binding Cassette Sub-family G Member 2, Human	1
AK1A1_RAT	P51635	CHEMBL3871	Aldehyde Reductase, Rat	1
AK1CL_MOUSE	Q91WR5	CHEMBL1075270	Aldo-keto Reductase Family 1 Member C21, Mouse	1
ALDR_BOVIN	P16116	CHEMBL3081	Aldose Reductase, Bovin	1
ALDR_HUMAN	P15121	CHEMBL1900	Aldose Reductase, Human	1
ALDR_RAT	P07943	CHEMBL2622	Aldose Reductase, Rat	1
AMPC_ECOLI	P00811	CHEMBL2026	Beta-lactamase, Ecoli	1
AMPH_ECOLI	P0AD70	CHEMBL4413	Penicillin-binding Protein AmpH, Ecoli	1
AOFA_BOVIN	P21398	CHEMBL3254	Monoamine Oxidase A, Bovin	1
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	1
AURKA_HUMAN	O14965	CHEMBL4722	Serine/threonine-protein Kinase Aurora-A, Human	1
AURKB_HUMAN	Q96GD4	CHEMBL2185	Serine/threonine-protein Kinase Aurora-B, Human	1
BCR_HUMAN	P11274	CHEMBL5146	Breakpoint Cluster Region Protein, Human	1
BRAF_HUMAN	P15056	CHEMBL5145	Serine/threonine-protein Kinase B-raf, Human	1
CAH12_HUMAN	O43570	CHEMBL3242	Carbonic Anhydrase XII, Human	1
CAH13_MOUSE	Q9D6N1	CHEMBL2186	Carbonic Anhydrase XIII, Mouse	1
CAH14_HUMAN	Q9ULX7	CHEMBL3510	Carbonic Anhydrase XIV, Human	1
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	1
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	1
CAH3_HUMAN	P07451	CHEMBL2885	Carbonic Anhydrase III, Human	1
CAH4_HUMAN	P22748	CHEMBL3729	Carbonic Anhydrase IV, Human	1
CAH5A_HUMAN	P35218	CHEMBL4789	Carbonic Anhydrase VA, Human	1
CAH6_HUMAN	P23280	CHEMBL3025	Carbonic Anhydrase VI, Human	1
CAH7_HUMAN	P43166	CHEMBL2326	Carbonic Anhydrase VII, Human	1
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	1
CDK19_HUMAN	Q9BWU1	CHEMBL6002	Cell Division Cycle 2-like Protein Kinase 6, Human	1
CDK1_HUMAN	P06493	CHEMBL308	Cyclin-dependent Kinase 1, Human	1
CLK1_HUMAN	P49759	CHEMBL4224	Dual Specificty Protein Kinase CLK1, Human	1
CP19A_HUMAN	P11511	CHEMBL1978	Cytochrome P450 19A1, Human	1
CP1B1_HUMAN	Q16678	CHEMBL4878	Cytochrome P450 1B1, Human	1
CSK22_HUMAN	P19784	CHEMBL4070	Casein Kinase II Alpha (prime), Human	1
DAPK1_HUMAN	P53355	CHEMBL2558	Death-associated Protein Kinase 1, Human	1
DAPK2_HUMAN	Q9UIK4	CHEMBL3123	Death-associated Protein Kinase 2, Human	1
DAPK3_HUMAN	O43293	CHEMBL2468	Death-associated Protein Kinase 3, Human	1
DHB2_HUMAN	P37059	CHEMBL2789	Estradiol 17-beta-dehydrogenase 2, Human	1
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	1
GSK3A_HUMAN	P49840	CHEMBL2850	Glycogen Synthase Kinase-3 Alpha, Human	1
IGF1R_HUMAN	P08069	CHEMBL1957	Insulin-like Growth Factor I Receptor, Human	1
KAPCA_HUMAN	P17612	CHEMBL4101	CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human	1
KAPCB_HUMAN	P22694	CHEMBL2918	CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human	1
KAPCG_HUMAN	P22612	CHEMBL2743	CAMP-dependent Protein Kinase, Gamma Catalytic Subunit, Human	1
KCC2A_MOUSE	P11798	CHEMBL3347	CaM Kinase II Alpha, Mouse	1
KCC2B_MOUSE	P28652	CHEMBL4735	CaM Kinase II Beta, Mouse	1
KCC2G_MOUSE	Q923T9	CHEMBL4456	CaM Kinase II Gamma, Mouse	1
KSYK_HUMAN	P43405	CHEMBL2599	Tyrosine-protein Kinase SYK, Human	1
LGUL_HUMAN	Q04760	CHEMBL2424	Glyoxalase I, Human	1
LIMK2_HUMAN	P53671	CHEMBL5932	LIM Domain Kinase 2, Human	1
LOX12_HUMAN	P18054	CHEMBL3687	Arachidonate 12-lipoxygenase, Human	1
LOX15_HUMAN	P16050	CHEMBL2903	Arachidonate 15-lipoxygenase, Human	1
LOX15_RABIT	P12530	CHEMBL4358	Arachidonate 15-lipoxygenase, Rabit	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
LOX5_RAT	P12527	CHEMBL312	Arachidonate 5-lipoxygenase, Rat	1
M3K9_HUMAN	P80192	CHEMBL2872	Mitogen-activated Protein Kinase Kinase Kinase 9, Human	1
MDH_THETH	P10584	CHEMBL4255	Malate Dehydrogenase, Theth	1
MET_HUMAN	P08581	CHEMBL3717	Hepatocyte Growth Factor Receptor, Human	1
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	1
MRP1_HUMAN	P33527	CHEMBL3004	Multidrug Resistance-associated Protein 1, Human	1
MYLK_CHICK	P11799	CHEMBL3062	Myosin Light Chain Kinase, Smooth Muscle, Chick	1
NANH_CLOPE	P10481	CHEMBL5189	Sialidase, Clope	1
NOX4_HUMAN	Q9NPH5	CHEMBL1250375	NADPH Oxidase 4, Human	1
NTRK1_HUMAN	P04629	CHEMBL2815	Nerve Growth Factor Receptor Trk-A, Human	1
PA21B_HUMAN	P04054	CHEMBL4426	Phospholipase A2 Group 1B, Human	1
PIM3_HUMAN	Q86V86	CHEMBL5407	Serine/threonine-protein Kinase PIM3, Human	1
PK3CA_MOUSE	P42337	CHEMBL2499	PI3-kinase P110-alpha Subunit, Mouse	1
Q965D5_PLAFA	Q965D5	CHEMBL4150	Enoyl-acyl-carrier Protein Reductase, Plafa	1
Q965D6_PLAFA	Q965D6	CHEMBL4513	3-oxoacyl-acyl-carrier Protein Reductase, Plafa	1
Q965D7_PLAFA	Q965D7	CHEMBL4512	Fatty Acid Synthase, Plafa	1
R1AB_CVHSA	P0C6X7	CHEMBL5118	Replicase Polyprotein 1ab, Cvhsa	1
RET_HUMAN	P07949	CHEMBL2041	Tyrosine-protein Kinase Receptor RET, Human	1
TGFR2_HUMAN	P37173	CHEMBL4267	TGF-beta Receptor Type II, Human	1
TIE2_HUMAN	Q02763	CHEMBL4128	Tyrosine-protein Kinase TIE-2, Human	1
TRY1_HUMAN	P07477	CHEMBL209	Trypsin I, Human	1
XDH_BOVIN	P80457	CHEMBL3649	Xanthine Dehydrogenase, Bovin	1
XDH_HUMAN	P47989	CHEMBL1929	Xanthine Dehydrogenase, Human	1