PRKDC_HUMAN - DNA-dependent Protein Kinase, Human | ZINC Is Not Commercial - A database of commercially-available compounds

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	525	20	4	8
Binding ≤ 1μM	290	10	1	6

Reactome ID	Description	Species
REACT_118823	Cytosolic sensors of pathogen-associated DNA	Homo sapiens
REACT_163993	IRF3-mediated induction of type I IFN	Homo sapiens
REACT_1022	Nonhomologous End-joining (NHEJ)	Homo sapiens
REACT_1201	Processing of DNA ends prior to end rejoining	Homo sapiens

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
PK3CA_HUMAN	P42336	CHEMBL4005	PI3-kinase P110-alpha Subunit, Human	197
PK3CD_HUMAN	O00329	CHEMBL3130	PI3-kinase P110-delta Subunit, Human	194
PK3CG_HUMAN	P48736	CHEMBL3267	PI3-kinase P110-gamma Subunit, Human	180
HCK_HUMAN	P08631	CHEMBL3234	Tyrosine-protein Kinase HCK, Human	160
SRC_HUMAN	P12931	CHEMBL267	Tyrosine-protein Kinase SRC, Human	158
MTOR_HUMAN	P42345	CHEMBL2842	FK506 Binding Protein 12, Human	157
ABL1_HUMAN	P00519	CHEMBL1862	Tyrosine-protein Kinase ABL, Human	149
PK3CB_HUMAN	P42338	CHEMBL3145	PI3-kinase P110-beta Subunit, Human	140
VGFR2_HUMAN	P35968	CHEMBL279	Vascular Endothelial Growth Factor Receptor 2, Human	124
EPHB4_HUMAN	P54760	CHEMBL5147	Ephrin Type-B Receptor 4, Human	115
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	113
PI4KB_HUMAN	Q9UBF8	CHEMBL3268	PI4-kinase Beta Subunit, Human	77
ATR_HUMAN	Q13535	CHEMBL5024	Serine-protein Kinase ATR, Human	27
ATM_HUMAN	Q13315	CHEMBL3797	Serine-protein Kinase ATM, Human	16
Q9BJF5_TOXGO	Q9BJF5	CHEMBL1781862	Calmodulin-domain Protein Kinase 1, Toxgo	8
P3C2B_HUMAN	O00750	CHEMBL5554	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human	4
P85A_HUMAN	P27986	CHEMBL2506	PI3-kinase P85-alpha Subunit, Human	4
PK3C3_HUMAN	Q8NEB9	CHEMBL1075165	Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human	3
AKT1_HUMAN	P31749	CHEMBL4282	Serine/threonine-protein Kinase AKT, Human	2
GSK3B_HUMAN	P49841	CHEMBL262	Glycogen Synthase Kinase-3 Beta, Human	2
MTOR_MOUSE	Q9JLN9	CHEMBL1255165	Serine/threonine-protein Kinase MTOR, Mouse	2
P3C2A_HUMAN	O00443	CHEMBL1075102	Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human	2
PLK1_HUMAN	P53350	CHEMBL3024	Serine/threonine-protein Kinase PLK1, Human	2
PLK3_HUMAN	Q9H4B4	CHEMBL4897	Serine/threonine-protein Kinase PLK3, Human	2
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	1
BCR_HUMAN	P11274	CHEMBL5146	Breakpoint Cluster Region Protein, Human	1
CDK1_HUMAN	P06493	CHEMBL308	Cyclin-dependent Kinase 1, Human	1
CHK1_HUMAN	O14757	CHEMBL4630	Serine/threonine-protein Kinase Chk1, Human	1
CHK2_HUMAN	O96017	CHEMBL2527	Serine/threonine-protein Kinase Chk2, Human	1
CP19A_HUMAN	P11511	CHEMBL1978	Cytochrome P450 19A1, Human	1
E2AK2_HUMAN	P19525	CHEMBL5785	Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human	1
ECE1_HUMAN	P42892	CHEMBL4791	Endothelin-converting Enzyme 1, Human	1
MRCKA_HUMAN	Q5VT25	CHEMBL4516	Serine/threonine-protein Kinase MRCK-A, Human	1
MYLK_CHICK	P11799	CHEMBL3062	Myosin Light Chain Kinase, Smooth Muscle, Chick	1
MYLK_HUMAN	Q15746	CHEMBL2428	Myosin Light Chain Kinase, Smooth Muscle, Human	1
NTRK1_HUMAN	P04629	CHEMBL2815	Nerve Growth Factor Receptor Trk-A, Human	1
P85B_HUMAN	O00459	CHEMBL4437	PI3-kinase P85-beta Subunit, Human	1
PIM1_HUMAN	P11309	CHEMBL2147	Serine/threonine-protein Kinase PIM1, Human	1
PIM3_HUMAN	Q86V86	CHEMBL5407	Serine/threonine-protein Kinase PIM3, Human	1
PK3CA_BOVIN	P32871	CHEMBL2498	PI3-kinase P110-alpha Subunit, Bovin	1
PK3CA_MOUSE	P42337	CHEMBL2499	PI3-kinase P110-alpha Subunit, Mouse	1
RET_HUMAN	P07949	CHEMBL2041	Tyrosine-protein Kinase Receptor RET, Human	1