UCSF
Image of 2-pyridone

Identity 99% 90% 80% 70% Substructure

2-pyridone

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Ring Information

Rings Ring Systems Atoms Carbons Nitrogens Oxygens Sulfurs
1 1 7 5 1 1 0

Subset Information

Substances Natural Purchasable Annotated BB In Man Last Updated
View 108 43,356 254 4,808 2 2012-03-06

Most Common Targets

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 40 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 31 Annotations Catalogs SMILES SDF Mol2 Flexibase
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 22 Annotations Catalogs SMILES SDF Mol2 Flexibase
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 22 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 20 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 19 Annotations Catalogs SMILES SDF Mol2 Flexibase
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 17 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 9 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 7 Annotations Catalogs SMILES SDF Mol2 Flexibase
Q8JXU8_9HEPC Q8JXU8 CHEMBL5375 Hepatitis C Virus NS5B RNA-dependent RNA Polymerase, 9hepc 7 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80169 Z80169 CHEMBL614039 Huh-7 (Hepatocellular Carcinoma) 7 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
ADRB2_CAVPO Q8K4Z4 CHEMBL5414 Beta-2 Adrenergic Receptor, Guinea Pig 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
FA10_HUMAN P00742 CHEMBL244 Coagulation Factor X, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
PARP1_HUMAN P09874 CHEMBL3105 Poly [ADP-ribose] Polymerase-1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
PARP1_HUMAN P09874 CHEMBL3105 Poly [ADP-ribose] Polymerase-1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
TRY2_BOVIN Q29463 CHEMBL4472 Trypsin II, Bovin 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
KCNA5_HUMAN P22460 CHEMBL4306 Voltage-gated Potassium Channel Subunit Kv1.5, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81131 Z81131 CHEMBL612266 L Cells (Fibroblasts) 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERG_HUMAN P11308 CHEMBL1293191 Transcriptional Regulator ERG, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
GYRA_ECOLI P0AES4 CHEMBL1858 DNA Gyrase Subunit A, Ecoli 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
GYRA_ECOLI P0AES4 CHEMBL1858 DNA Gyrase Subunit A, Ecoli 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
GYRB_ECOLI P0AES6 CHEMBL1826 DNA Gyrase Subunit B, Ecoli 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
GYRB_ECOLI P0AES6 CHEMBL1826 DNA Gyrase Subunit B, Ecoli 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PARC_STAAU P0C1U9 CHEMBL4088 Topoisomerase IV Subunit A, Staau 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
TOP1_HUMAN P11387 CHEMBL1781 DNA Topoisomerase I, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
TOP1_HUMAN P11387 CHEMBL1781 DNA Topoisomerase I, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z103203 Z103203 CHEMBL1075388 A375 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
AAKB1_HUMAN Q9Y478 CHEMBL3847 AMP-activated Protein Kinase, Beta-1 Subunit, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase