UCSF

Prostanoid EP3 Receptor, Human (475 Compounds)

Swissprot:
PE2R3_HUMAN
Stitch:
PE2R3_HUMAN
UniProt:
P43115
ChEMBL:
CHEMBL3710
Reactome:
REACT_19231
REACT_18425
PDB:
PTGER3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 475 9 3 4
Binding ≤ 1μM 411 7 3 4
Functional ≤ 10μM 88 12 1 2

Reactome Network (2)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_18425 Prostanoid ligand receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 1
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 5
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 5
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 4
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1

Prostanoid ligand receptors

Uniprot Swissprot Chembl Description Number Shared
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 2
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 24
PE2R1_HUMAN P34995 CHEMBL1811 Prostanoid EP1 Receptor, Human 88
PE2R2_HUMAN P43116 CHEMBL1881 Prostanoid EP2 Receptor, Human 127
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 145
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 44
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 16
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 34
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PE2R3_MOUSE P30557 CHEMBL4336 Prostanoid EP3 Receptor, Mouse 243 4 3 4
PE2R3_RAT P34980 CHEMBL5674 Prostaglandin E2 Receptor EP3 Subtype, Rat 3 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PE2R1_HUMAN P34995 CHEMBL1811 Prostanoid EP1 Receptor, Human 213 6 3 4
PE2R2_HUMAN P43116 CHEMBL1881 Prostanoid EP2 Receptor, Human 193 10 3 3
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 376 7 2 2

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
PE2R3-1-E Prostanoid EP3 Receptor (cluster #1 Of 3), Eukaryotic 621 2 1 1
PE2R3-2-E Prostanoid EP3 Receptor (cluster #2 Of 3), Eukaryotic 64 13 5 7
PE2R3-3-E Prostanoid EP3 Receptor (cluster #3 Of 3), Eukaryotic 41 0 0 0
Uniprot Swissprot Chembl Description Number Shared
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 143
PE2R2_HUMAN P43116 CHEMBL1881 Prostanoid EP2 Receptor, Human 125
PE2R1_HUMAN P34995 CHEMBL1811 Prostanoid EP1 Receptor, Human 87
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 42
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 30
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 22
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 16
PE2R3_MOUSE P30557 CHEMBL4336 Prostanoid EP3 Receptor, Mouse 7
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 5
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 5
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 5
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 4
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 4
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 1
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 1
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
AGTR2_RAT P35351 CHEMBL257 Angiotensin II Type 2 (AT-2) Receptor, Rat 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
PE2R1_RAT P70597 CHEMBL5068 Prostanoid EP1 Receptor, Rat 1
PE2R2_RAT Q62928 CHEMBL4909 Prostanoid EP2 Receptor, Rat 1
PE2R4_RAT P43114 CHEMBL4086 Prostanoid EP4 Receptor, Rat 1
PF2R_BOVIN P37289 CHEMBL4820 Prostanoid FP Receptor, Bovin 1
PF2R_MOUSE P43117 CHEMBL5000 Prostaglandin F2-alpha Receptor, Mouse 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
S22A6_MOUSE Q8VC69 CHEMBL5653 Solute Carrier Family 22 Member 6, Mouse 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
TYPH_HUMAN P19971 CHEMBL3106 Thymidine Phosphorylase, Human 1
Z50589 Z50589 CHEMBL612670 Felis Catus 1
Z80530 Z80530 CHEMBL614946 Swiss-3T3 (Fibroblast Cells) 1

Most Common Rings