ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (376)
Reactome (2)
Related By:
Pathway (13)
Organism (2)
Gene (3)
Org. Clust. (1)
ChEMBL (42)
Rings (11)

Prostanoid EP4 Receptor, Human (376 Compounds)

Swissprot:: PE2R4_HUMAN
Stitch:: PE2R4_HUMAN
UniProt:: P35408
ChEMBL:: CHEMBL1836
Reactome:: REACT_19327; REACT_18425
PDB:: PTGER4

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	376	7	2	2
Binding ≤ 1μM	280	6	1	1
Functional ≤ 10μM	144	2	1	1

Reactome ID	Description	Species
REACT_19327	G alpha (s) signalling events	Homo sapiens
REACT_18425	Prostanoid ligand receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	1
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	1
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	5
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	4
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	27
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	168
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	12

Prostanoid ligand receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GPR44_HUMAN	Q9Y5Y4	CHEMBL5071	G Protein-coupled Receptor 44, Human	1
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	27
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	64
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	168
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	145
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	15
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	12
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	21

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PE2R4_MOUSE	P32240	CHEMBL2489	Prostanoid EP4 Receptor, Mouse	112	3	3	3
PE2R4_RAT	P43114	CHEMBL4086	Prostanoid EP4 Receptor, Rat	79	1	1	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	213	6	3	4
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	193	10	3	3
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	475	9	3	4

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
PE2R4-1-E	Prostanoid EP4 Receptor (cluster #1 Of 2), Eukaryotic	445	1	0	0
PE2R4-2-E	Prostanoid EP4 Receptor (cluster #2 Of 2), Eukaryotic	114	11	5	5

Uniprot	Swissprot	Chembl	Description	Number Shared
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	168
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	143
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	64
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	26
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	19
PE2R4_RAT	P43114	CHEMBL4086	Prostanoid EP4 Receptor, Rat	18
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	15
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	12
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	5
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	5
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	5
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	4
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	4
PE2R3_MOUSE	P30557	CHEMBL4336	Prostanoid EP3 Receptor, Mouse	4
PE2R3_RAT	P34980	CHEMBL5674	Prostaglandin E2 Receptor EP3 Subtype, Rat	3
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
PE2R2_MOUSE	Q62053	CHEMBL2488	Prostanoid EP2 Receptor, Mouse	2
PE2R2_RAT	Q62928	CHEMBL4909	Prostanoid EP2 Receptor, Rat	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	1
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	1
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	1
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	1
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	1
AGTR2_RAT	P35351	CHEMBL257	Angiotensin II Type 2 (AT-2) Receptor, Rat	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
GPR44_HUMAN	Q9Y5Y4	CHEMBL5071	G Protein-coupled Receptor 44, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	1
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	1
PF2R_BOVIN	P37289	CHEMBL4820	Prostanoid FP Receptor, Bovin	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
S22A6_MOUSE	Q8VC69	CHEMBL5653	Solute Carrier Family 22 Member 6, Mouse	1
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	1
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	1
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	1
TYPH_HUMAN	P19971	CHEMBL3106	Thymidine Phosphorylase, Human	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1