UCSF

Angiotensin II Type 1 Receptor, Human (1,045 Compounds)

Swissprot:
AGTR1_HUMAN
Stitch:
AGTR1_HUMAN
UniProt:
P30556
ChEMBL:
CHEMBL227
Reactome:
REACT_18283
REACT_14819
PDB:
1ZV0 (DOCK)
AGTR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,045 14 9 13
Binding ≤ 1μM 984 13 9 13
Functional ≤ 10μM 331 4 3 3

Reactome Network (2)

Reactome ID Description Species
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_14819 Peptide ligand-binding receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 6
EDNRB_HUMAN P24530 CHEMBL1785 Endothelin Receptor ET-B, Human 4
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
AGTR2_HUMAN P50052 CHEMBL4607 Angiotensin II Type 2 (AT-2) Receptor, Human 352
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 6
EDNRB_HUMAN P24530 CHEMBL1785 Endothelin Receptor ET-B, Human 4
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AGTR1_BOVIN P25104 CHEMBL3374 Angiotensin II Type 1a (AT-1a) Receptor, Bovin 294 9 5 4
AGTR1_CAVPO Q9WV26 CHEMBL1671613 Type-1 Angiotensin II Receptor, Guinea Pig 5 1 0 1
AGTR1_PIG P30555 CHEMBL5743 Type-1 Angiotensin II Receptor, Pig 25 1 0 0
AGTR1_RABIT P34976 CHEMBL3948 Angiotensin II Type 1a (AT-1a) Receptor, Rabit 134 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AGTR2_HUMAN P50052 CHEMBL4607 Angiotensin II Type 2 (AT-2) Receptor, Human 493 12 7 4

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
AGTR1-1-E Type-1 Angiotensin II Receptor (cluster #1 Of 2), Eukaryotic 1,427 20 11 15
AGTR1-2-E Type-1 Angiotensin II Receptor (cluster #2 Of 2), Eukaryotic 13 0 0 0
Uniprot Swissprot Chembl Description Number Shared
AGTR2_RAT P35351 CHEMBL257 Angiotensin II Type 2 (AT-2) Receptor, Rat 420
AGTR2_HUMAN P50052 CHEMBL4607 Angiotensin II Type 2 (AT-2) Receptor, Human 352
AGTRB_RAT P29089 CHEMBL263 Angiotensin II Type 1b (AT-1b) Receptor, Rat 197
AGTRA_RAT P25095 CHEMBL329 Angiotensin II Type 1a (AT-1a) Receptor, Rat 155
AGTR1_RABIT P34976 CHEMBL3948 Angiotensin II Type 1a (AT-1a) Receptor, Rabit 59
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 17
AGTR1_BOVIN P25104 CHEMBL3374 Angiotensin II Type 1a (AT-1a) Receptor, Bovin 9
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 6
EDNRB_HUMAN P24530 CHEMBL1785 Endothelin Receptor ET-B, Human 4
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 3
AGTR1_CAVPO Q9WV26 CHEMBL1671613 Type-1 Angiotensin II Receptor, Guinea Pig 2
Z80902 Z80902 CHEMBL614150 HASMC (Aortic Smooth Muscle Cells) 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
AGTR1_PIG P30555 CHEMBL5743 Type-1 Angiotensin II Receptor, Pig 1
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
GHSR_PIG Q95254 CHEMBL2224 Ghrelin Receptor, Pig 1
GHSR_RAT O08725 CHEMBL3278 Ghrelin Receptor, Rat 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 1
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1

Most Common Rings