ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (1,225)
Reactome (2)
Related By:
Pathway (22)
Organism (3)
Gene (0)
Org. Clust. (2)
ChEMBL (63)
Rings (25)

Endothelin Receptor ET-A, Human (1,225 Compounds)

Swissprot:: EDNRA_HUMAN
Stitch:: EDNRA_HUMAN
UniProt:: P25101
ChEMBL:: CHEMBL252
Reactome:: REACT_18283; REACT_14819
PDB:: EDNRA

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,225	26	7	11
Binding ≤ 1μM	1,097	26	7	11
Functional ≤ 10μM	168	7	1	1

Reactome ID	Description	Species
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_14819	Peptide ligand-binding receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	6
EDNRB_HUMAN	P24530	CHEMBL1785	Endothelin Receptor ET-B, Human	842
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2

Peptide ligand-binding receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	6
AGTR2_HUMAN	P50052	CHEMBL4607	Angiotensin II Type 2 (AT-2) Receptor, Human	2
EDNRB_HUMAN	P24530	CHEMBL1785	Endothelin Receptor ET-B, Human	842
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
EDNRA_MOUSE	Q61614	CHEMBL2286	Endothelin Receptor ET-A, Mouse	16	2	0	0
EDNRA_PIG	Q29010	CHEMBL4130	Endothelin Receptor ET-A, Pig	264	2	1	1
EDNRA_RAT	P26684	CHEMBL4566	Endothelin Receptor ET-A, Rat	905	11	6	10

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
EDNRA-1-E	Endothelin Receptor ET-A (cluster #1 Of 3), Eukaryotic	1,615	22	3	9
EDNRA-2-E	Endothelin Receptor ET-A (cluster #2 Of 3), Eukaryotic	10	0	0	0
EDNRA-3-E	Endothelin Receptor ET-A (cluster #3 Of 3), Eukaryotic	711	8	7	9

Uniprot	Swissprot	Chembl	Description	Number Shared
EDNRB_HUMAN	P24530	CHEMBL1785	Endothelin Receptor ET-B, Human	842
EDNRB_PIG	P35463	CHEMBL3949	Endothelin Receptor ET-B, Pig	67
EDNRA_RAT	P26684	CHEMBL4566	Endothelin Receptor ET-A, Rat	65
EDNRA_PIG	Q29010	CHEMBL4130	Endothelin Receptor ET-A, Pig	28
AGTRB_RAT	P29089	CHEMBL263	Angiotensin II Type 1b (AT-1b) Receptor, Rat	26
AGTRA_RAT	P25095	CHEMBL329	Angiotensin II Type 1a (AT-1a) Receptor, Rat	25
EDNRB_RAT	P21451	CHEMBL4631	Endothelin Receptor ET-B, Rat	15
AGTR1_HUMAN	P30556	CHEMBL227	Angiotensin II Type 1 Receptor, Human	6
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	2
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	2
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	2
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	2
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	2
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	2
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	2
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	2
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	2
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	2
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	2
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	2
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	2
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	2
AGTR2_HUMAN	P50052	CHEMBL4607	Angiotensin II Type 2 (AT-2) Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	2
EDNRA_MOUSE	Q61614	CHEMBL2286	Endothelin Receptor ET-A, Mouse	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	2
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	2
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1