ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (470)
Reactome (2)
Related By:
Pathway (17)
Organism (2)
Gene (4)
Org. Clust. (3)
ChEMBL (162)
Rings (37)

Muscarinic Acetylcholine Receptor M5, Human (470 Compounds)

Swissprot:: ACM5_HUMAN
Stitch:: ACM5_HUMAN
UniProt:: P08912
ChEMBL:: CHEMBL2035
Reactome:: REACT_18283; REACT_16943
PDB:: CHRM5

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	470	45	23	24
Binding ≤ 1μM	277	33	17	21
Functional ≤ 10μM	64	10	4	4

Reactome ID	Description	Species
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_16943	Muscarinic acetylcholine receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	21
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	21
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	21
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	461
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	468
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	22
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	14
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	14
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	14
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2

Muscarinic acetylcholine receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	461
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	459
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	468
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	465

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ACM5_MOUSE	Q920H4	CHEMBL2324	Muscarinic Acetylcholine Receptor M5, Mouse	4	4	4	4
ACM5_RAT	P08911	CHEMBL277	Muscarinic Acetylcholine Receptor M5, Rat	48	3	3	3

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	1,053	70	41	43
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	1,202	58	34	37
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1,056	55	33	35
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	536	44	30	27

Clustered By Gene (0)

Clustered By Organism (3)

Code	Description	Substances	Purchasable	Natural	In Man
ACM5-1-E	Muscarinic Acetylcholine Receptor M5 (cluster #1 Of 4), Eukaryotic	91	7	5	3
ACM5-2-E	Muscarinic Acetylcholine Receptor M5 (cluster #2 Of 4), Eukaryotic	151	33	18	20
ACM5-3-E	Muscarinic Acetylcholine Receptor M5 (cluster #3 Of 4), Eukaryotic	271	10	6	8
ACM5-4-E	Muscarinic Acetylcholine Receptor M5 (cluster #4 Of 4), Eukaryotic	10	2	1	0

Uniprot	Swissprot	Chembl	Description	Number Shared
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	468
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	465
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	460
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	459
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	59
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	53
ACM3_RAT	P08483	CHEMBL320	Muscarinic Acetylcholine Receptor M3, Rat	38
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	36
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	22
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	22
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	21
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	21
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	21
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	20
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	15
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	14
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	14
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	14
ACM5_RAT	P08911	CHEMBL277	Muscarinic Acetylcholine Receptor M5, Rat	13
Z50512	Z50512	CHEMBL369	Cavia Porcellus	13
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	12
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	12
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	11
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	11
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	10
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	9
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	9
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	9
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	8
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	7
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	7
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	6
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	6
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	6
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	6
ACM1_MOUSE	P12657	CHEMBL3733	Muscarinic Acetylcholine Receptor M1, Mouse	6
ACM4_RAT	P08485	CHEMBL317	Muscarinic Acetylcholine Receptor M4, Rat	6
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	6
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	6
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	6
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	5
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	5
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	5
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	5
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	5
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	5
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	5
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	5
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	5
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	5
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	5
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	5
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	5
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	4
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	4
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	4
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	4
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	4
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	4
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	4
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	4
Q8WMX0_BOVIN	Q8WMX0	CHEMBL2672	Muscarinic Acetylcholine Receptor M1, Bovin	4
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	4
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	4
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	4
Z80024	Z80024	CHEMBL614518	A9 (Fibroblast Cells)	4
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	3
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	3
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	3
5HT2A_MOUSE	P35363	CHEMBL5377	Serotonin 2a (5-HT2a) Receptor, Mouse	3
5HT2B_MOUSE	Q02152	CHEMBL2583	Serotonin 2b (5-HT2b) Receptor, Mouse	3
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	3
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	3
ACM2_MOUSE	Q9ERZ4	CHEMBL3197	Muscarinic Acetylcholine Receptor M2, Mouse	3
ACM3_MOUSE	Q9ERZ3	CHEMBL5105	Muscarinic Acetylcholine Receptor M3, Mouse	3
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	3
CHLE_HUMAN	P06276	CHEMBL1914	Butyrylcholinesterase, Human	3
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	3
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	3
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	3
Z104290	Z104290	CHEMBL1907596	Neuronal Acetylcholine Receptor; Alpha4/beta2	3
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	3
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	2
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	2
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	2
5HT4R_CAVPO	O70528	CHEMBL5017	Serotonin 4 (5-HT4) Receptor, Guinea Pig	2
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ACES_MOUSE	P21836	CHEMBL3198	Acetylcholinesterase, Mouse	2
ACHA2_RAT	P12389	CHEMBL2584	Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat	2
ACHA3_RAT	P04757	CHEMBL3818	Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat	2
ACHA7_HUMAN	P36544	CHEMBL2492	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human	2
ACHA7_RAT	Q05941	CHEMBL4980	Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat	2
ACHB2_RAT	P12390	CHEMBL3001	Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat	2
ACHB4_RAT	P12392	CHEMBL2658	Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat	2
ACHD_TORCA	P02718	CHEMBL3916	Acetylcholine Receptor Protein Delta Chain, Torca	2
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	2
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	2
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	2
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	2
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	2
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	2
DRD2_CHLAE	P52702	CHEMBL5456	Dopamine D2 Receptor, Chlae	2
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	2
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
Z102306	Z102306	CHEMBL613606	Aorta	2
Z104281	Z104281	CHEMBL1907587	Neuronal Acetylcholine Receptor; Alpha3/beta2	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z104286	Z104286	CHEMBL1907592	Neuronal Acetylcholine Receptor; Alpha2/beta2	2
Z104287	Z104287	CHEMBL1907593	Neuronal Acetylcholine Receptor; Alpha3/beta4	2
Z104289	Z104289	CHEMBL1907595	Neuronal Acetylcholine Receptor; Alpha4/beta4	2
5HT2A_PIG	P50129	CHEMBL2490	Serotonin 2a (5-HT2a) Receptor, Pig	1
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	1
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	1
ACES_BOVIN	P23795	CHEMBL4768	Acetylcholinesterase, Bovin	1
ACH10_RAT	Q9JLB5	CHEMBL3461	Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat	1
ACHA4_RAT	P09483	CHEMBL307	Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat	1
ACHP_LYMST	P58154	CHEMBL6084	Acetylcholine-binding Protein, Lymst	1
ACM4_MOUSE	P32211	CHEMBL4572	Muscarinic Acetylcholine Receptor M4, Mouse	1
ACM5_MOUSE	Q920H4	CHEMBL2324	Muscarinic Acetylcholine Receptor M5, Mouse	1
ADRB2_CANFA	P54833	CHEMBL2289	Beta-2 Adrenergic Receptor, Canine	1
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	1
AMYP_RAT	P00689	CHEMBL2699	Pancreatic Alpha-amylase, Rat	1
AP2S1_RAT	P62744	CHEMBL1697667	AP-2 Complex Subunit Sigma, Rat	1
EBP_HUMAN	Q15125	CHEMBL4931	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human	1
ERG2_YEAST	P32352	CHEMBL3224	C-8 Sterol Isomerase, Yeast	1
HRH1_CAVPO	P31389	CHEMBL3943	Histamine H1 Receptor, Guinea Pig	1
HRH2_RAT	P25102	CHEMBL4654	Histamine H2 Receptor, Rat	1
HRH3_CAVPO	Q9JI35	CHEMBL5076	Histamine H3 Receptor, Guinea Pig	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	1
MDR1_HUMAN	P08183	CHEMBL4302	P-glycoprotein 1, Human	1
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	1
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	1
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	1
OPRX_HUMAN	P41146	CHEMBL2014	Nociceptin Receptor, Human	1
Q4U254_9ENTO	Q4U254	CHEMBL2857	Human Rhinovirus A Protease, 9ento	1
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	1