UCSF

Histamine H2 Receptor, Human (144 Compounds)

Swissprot:
HRH2_HUMAN
Stitch:
HRH2_HUMAN
UniProt:
P25021
ChEMBL:
CHEMBL1941
Reactome:
REACT_19327
REACT_16903
PDB:
HRH2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 144 13 10 5
Binding ≤ 1μM 64 5 6 4
Functional ≤ 10μM 11 9 9 9

Reactome Network (2)

Reactome ID Description Species
REACT_19327 G alpha (s) signalling events Homo sapiens
REACT_16903 Histamine receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 4
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 22
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 6
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 6
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 6
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 7
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 5
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 21
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 13
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2

Histamine receptors

Uniprot Swissprot Chembl Description Number Shared
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 59
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 36
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 31
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HRH2_CAVPO P47747 CHEMBL2882 Histamine H2 Receptor, Guinea Pig 16 4 4 4
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 23 3 3 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 529 66 50 47
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2,395 54 18 9
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 470 55 13 4

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
HRH2-1-E Histamine H2 Receptor (cluster #1 Of 3), Eukaryotic 139 8 6 5
HRH2-2-E Histamine H2 Receptor (cluster #2 Of 3), Eukaryotic 32 6 7 4
HRH2-3-E Histamine H2 Receptor (cluster #3 Of 3), Eukaryotic 3 3 1 1
Uniprot Swissprot Chembl Description Number Shared
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 57
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 46
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 39
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 36
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 31
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 25
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 22
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 21
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 20
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 18
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 18
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 18
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 17
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 17
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 16
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 16
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 16
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 16
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 15
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 15
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 15
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 14
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 13
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 13
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 12
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 12
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 10
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 10
HRH2_CAVPO P47747 CHEMBL2882 Histamine H2 Receptor, Guinea Pig 10
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 10
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 9
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 8
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 7
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 7
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 7
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 7
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 7
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 7
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 7
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 7
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 6
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 6
HRH4_MOUSE Q91ZY2 CHEMBL5657 Histamine H4 Receptor, Mouse 6
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 6
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 6
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 5
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 5
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 5
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 5
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 5
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 4
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 4
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 4
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 4
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 4
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 4
Z50594 Z50594 CHEMBL375 Mus Musculus 4
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 3
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 3
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 3
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 3
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 3
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 2
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 2
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 2
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 2
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CCKAR_RAT P30551 CHEMBL2871 Cholecystokinin A Receptor, Rat 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 2
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 2
HRH3_MOUSE P58406 CHEMBL3263 Histamine H3 Receptor, Mouse 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 2
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 2
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
ATP4A_HUMAN P20648 CHEMBL1802 Potassium-transporting ATPase Alpha Chain 1, Human 1
ATP4B_HUMAN P51164 CHEMBL5207 Potassium-transporting ATPase Beta Chain, Human 1
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 1
HNMT_RAT Q01984 CHEMBL3241 Histamine N-methyltransferase, Rat 1
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z81138 Z81138 CHEMBL613872 ScN2a (Scrapie-infected Neuroblastoma Cells) 1

Most Common Rings