UCSF

Trypanosoma Cruzi (5 Compounds)

Swissprot:
Z50466
Stitch:
Z50466
UniProt:
Z50466
ChEMBL:
CHEMBL368

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 5 0 0 0
Binding ≤ 1μM 0 0 0 0
Functional ≤ 10μM 718 80 69 46
ADME/T ≤ 10μM 0 0 0 0

Reactome Network (0)

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
Z50725 Z50725 CHEMBL612348 Trypanosoma Brucei Rhodesiense 107
Z50459 Z50459 CHEMBL367 Leishmania Donovani 90
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 86
Z50426 Z50426 CHEMBL612856 Plasmodium Falciparum (isolate K1 / Thailand) 46
Z50457 Z50457 CHEMBL612877 Leishmania Amazonensis 39
Z50458 Z50458 CHEMBL612878 Leishmania Braziliensis 26
Z50418 Z50418 CHEMBL612849 Trypanosoma Brucei 25
Z50420 Z50420 CHEMBL612851 Trypanosoma Brucei Brucei 18
Z80291 Z80291 CHEMBL614181 MRC5 (Embryonic Lung Fibroblast Cells) 11
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 8
Z50460 Z50460 CHEMBL612879 Leishmania Major 7
Z50472 Z50472 CHEMBL612888 Toxoplasma Gondii 7
Z81135 Z81135 CHEMBL614793 L6 (Skeletal Muscle Myoblast Cells) 7
Z101874 Z101874 CHEMBL612914 Leishmania Pifanoi 5
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 4
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 4
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 4
Z101865 Z101865 CHEMBL612790 Leishmania Chagasi 4
Z50512 Z50512 CHEMBL369 Cavia Porcellus 4
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 4
Z50594 Z50594 CHEMBL375 Mus Musculus 4
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 4
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 3
Z50417 Z50417 CHEMBL612848 Leishmania Infantum 3
Z50461 Z50461 CHEMBL612880 Leishmania Mexicana 3
Z50468 Z50468 CHEMBL612652 Giardia Intestinalis 3
Z50473 Z50473 CHEMBL612653 Plasmodium Berghei 3
Z50587 Z50587 CHEMBL372 Homo Sapiens 3
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 3
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 3
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 2
CAC1E_RAT Q07652 CHEMBL4115 Voltage-gated R-type Calcium Channel Alpha-1E Subunit, Rat 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 2
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 2
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 2
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 2
Z101873 Z101873 CHEMBL613215 Leishmania Peruviana 2
Z50422 Z50422 CHEMBL612853 Entamoeba Histolytica 2
Z50467 Z50467 CHEMBL612884 Trichomonas Vaginalis 2
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 2
Z50691 Z50691 CHEMBL613768 Trypanosoma Brucei Gambiense 2
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 2
Z80133 Z80133 CHEMBL614294 EMT6 (Mammary Carcinoma Cells) 2
Z80175 Z80175 CHEMBL614585 IMR-32 (Neuroblastoma Cells) 2
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 2
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 2
Z80593 Z80593 CHEMBL612808 WiDr-NTR 2
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 2
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 2
Z81225 Z81225 CHEMBL614073 M109 (Lung Carcinoma Cells) 2
Z81240 Z81240 CHEMBL614121 MAC15A (Colon Adenocarcinoma Cells) 2
Z81264 Z81264 CHEMBL614074 V79 (Lung Fibroblasts) 2
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 1
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FNTA_MOUSE Q61239 CHEMBL2153 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Mouse 1
FNTB_MOUSE Q8K2I1 CHEMBL2631 Protein Farnesyltransferase Beta Subunit, Mouse 1
GPBAR_HUMAN Q8TDU6 CHEMBL5409 G-protein Coupled Bile Acid Receptor 1, Human 1
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 1
GRIK2_HUMAN Q13002 CHEMBL3683 Glutamate Receptor Ionotropic Kainate 2, Human 1
GRIK2_RAT P42260 CHEMBL3607 Glutamate Receptor Ionotropic Kainate 2, Rat 1
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
Q8X6S1_ECO57 Q8X6S1 CHEMBL5502 Modulator Of Drug Activity A, Eco57 1
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 1
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
Z101870 Z101870 CHEMBL612793 Leishmania Guyanensis 1
Z101879 Z101879 CHEMBL612917 Leptomonas Seymouri 1
Z102121 Z102121 CHEMBL613162 Trichophyton Mentagrophytes 1
Z103204 Z103204 CHEMBL1075389 A427 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z50274 Z50274 CHEMBL614955 Aspergillus Flavus 1
Z50275 Z50275 CHEMBL358 Aspergillus Niger 1
Z50339 Z50339 CHEMBL613064 Pneumocystis Carinii 1
Z50347 Z50347 CHEMBL361 Saccharomyces Cerevisiae 1
Z50380 Z50380 CHEMBL613088 Mycobacterium Smegmatis 1
Z50408 Z50408 CHEMBL612841 Issatchenkia Orientalis 1
Z50416 Z50416 CHEMBL363 Aspergillus Fumigatus 1
Z50436 Z50436 CHEMBL365 Filobasidiella Neoformans 1
Z50442 Z50442 CHEMBL366 Candida Albicans 1
Z50443 Z50443 CHEMBL612647 Candida Glabrata 1
Z50444 Z50444 CHEMBL612868 Candida Parapsilosis 1
Z50446 Z50446 CHEMBL612870 Candida Tropicalis 1
Z50452 Z50452 CHEMBL612649 Trichophyton Rubrum 1
Z50600 Z50600 CHEMBL613493 Vaccinia Virus 1
Z80002 Z80002 CHEMBL614075 1A9 (Ovarian Adenocarcinoma Cells) 1
Z80021 Z80021 CHEMBL614516 A498 (Renal Carcinoma Cells) 1
Z80026 Z80026 CHEMBL613860 AGS (Gastric Adenocarcinoma Cells) 1
Z80035 Z80035 CHEMBL381 B16 (Melanoma Cells) 1
Z80036 Z80036 CHEMBL614524 BaF3 (IL-3-dependent Pro-B-cells) 1
Z80091 Z80091 CHEMBL614557 CHO-hD3 1
Z80099 Z80099 CHEMBL614561 COLO 205 (Colon Adenocarcinoma Cells) 1
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 1
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 1
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80490 Z80490 CHEMBL614923 SK-MES-1 1
Z80561 Z80561 CHEMBL615023 U2OS (Osteosarcoma Cells) 1
Z80583 Z80583 CHEMBL391 Vero (Kidney Cells) 1
Z80653 Z80653 CHEMBL613105 9L (Glioma Cells) 1
Z80695 Z80695 CHEMBL614798 BE (Colon Adenocarcinoma Cells) 1
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 1
Z80773 Z80773 CHEMBL614456 CHRC/5 Cell Line 1
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 1
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 1
Z80980 Z80980 CHEMBL614736 HOS (Osteosarcoma Cells) 1
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 1
Z81068 Z81068 CHEMBL614649 Ishikawa (Uterine Carcinoma Cells) 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81338 Z81338 CHEMBL614309 T-cells 1