UCSF

Cytochrome P450 17A1, Human (690 Compounds)

Swissprot:
CP17A_HUMAN
Stitch:
CP17A_HUMAN
UniProt:
P05093
ChEMBL:
CHEMBL3522
Reactome:
REACT_11059
REACT_13812
REACT_11036
PDB:
2C17 (DOCK)
3RUK (DOCK)
3SWZ (DOCK)
CYP17A1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 690 50 29 14
Binding ≤ 1μM 556 34 18 14
Functional ≤ 10μM 1 1 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_11059 Androgen biosynthesis Homo sapiens
REACT_13812 Endogenous sterols Homo sapiens
REACT_11036 Glucocorticoid biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
S5A1_HUMAN P18405 CHEMBL1787 Steroid 5-alpha-reductase 1, Human 32
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 40

Endogenous sterols

Uniprot Swissprot Chembl Description Number Shared
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 40
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 43
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 53
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 3
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 9

Glucocorticoid biosynthesis

Uniprot Swissprot Chembl Description Number Shared
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 40
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 43
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 324 15 6 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CP17A-1-E Cytochrome P450 17A1 (cluster #1 Of 2), Eukaryotic 353 25 13 12
CP17A-2-E Cytochrome P450 17A1 (cluster #2 Of 2), Eukaryotic 435 42 17 2
Uniprot Swissprot Chembl Description Number Shared
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 245
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 53
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 43
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 40
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 36
S5A1_HUMAN P18405 CHEMBL1787 Steroid 5-alpha-reductase 1, Human 28
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 16
Q5EM59_BOVIN Q5EM59 CHEMBL3953 Androgen Receptor, Bovin 16
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 10
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 9
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 5
CP51_MYCTU P0A512 CHEMBL5090 Lanosterol 14-alpha Demethylase, Myctu 5
CP11A_BOVIN P00189 CHEMBL4813 Cytochrome P450 11A1, Bovin 4
CP51A_RAT Q64654 CHEMBL4981 Cytochrome P450 51, Rat 4
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 4
C11B1_BOVIN P15150 CHEMBL2927 Cytochrome P450 11B1, Bovin 3
CP11A_RAT P14137 CHEMBL5246 Cytochrome P450 11A1, Rat 3
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 3
CP7A1_RAT P18125 CHEMBL2339 Cytochrome P450 7A1, Rat 3
CP19A_RAT P22443 CHEMBL3859 Cytochrome P450 19A1, Rat 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
Q64546_RAT Q64546 CHEMBL1687684 Cytochrome P450c11B3, Rat 2
CP24A_HUMAN Q07973 CHEMBL4521 Cytochrome P450 24A1, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HMOX1_RAT P06762 CHEMBL5035 Heme Oxygenase 1, Rat 1
KCNA3_HUMAN P22001 CHEMBL4633 Voltage-gated Potassium Channel Subunit Kv1.3, Human 1
KCNN4_HUMAN O15554 CHEMBL4305 Intermediate Conductance Calcium-activated Potassium Channel Protein 4, Human 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
MDR1_MOUSE P06795 CHEMBL3467 P-glycoprotein 1, Mouse 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
Q4WNT5_ASPFU Q4WNT5 CHEMBL1681623 14-alpha Sterol Demethylase Cyp51A, Aspfu 1
Q96W81_ASPFM Q96W81 CHEMBL1681624 14-alpha Sterol Demethylase, Aspfm 1
Z102121 Z102121 CHEMBL613162 Trichophyton Mentagrophytes 1
Z50274 Z50274 CHEMBL614955 Aspergillus Flavus 1
Z50275 Z50275 CHEMBL358 Aspergillus Niger 1
Z50408 Z50408 CHEMBL612841 Issatchenkia Orientalis 1
Z50416 Z50416 CHEMBL363 Aspergillus Fumigatus 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50436 Z50436 CHEMBL365 Filobasidiella Neoformans 1
Z50442 Z50442 CHEMBL366 Candida Albicans 1
Z50443 Z50443 CHEMBL612647 Candida Glabrata 1
Z50444 Z50444 CHEMBL612868 Candida Parapsilosis 1
Z50446 Z50446 CHEMBL612870 Candida Tropicalis 1
Z50452 Z50452 CHEMBL612649 Trichophyton Rubrum 1
Z50459 Z50459 CHEMBL367 Leishmania Donovani 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1

Most Common Rings