UCSF

Cytochrome P450 11B1, Human (325 Compounds)

Swissprot:
C11B1_HUMAN
Stitch:
C11B1_HUMAN
UniProt:
P15538
ChEMBL:
CHEMBL1908
Reactome:
REACT_13812
REACT_11036
REACT_11047
PDB:
CYP11B1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 325 43 8 9
Binding ≤ 1μM 243 35 8 9

Reactome Network (3)

Reactome ID Description Species
REACT_13812 Endogenous sterols Homo sapiens
REACT_11036 Glucocorticoid biosynthesis Homo sapiens
REACT_11047 Mineralocorticoid biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 316
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 40
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 78
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 1
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 2

Glucocorticoid biosynthesis

Uniprot Swissprot Chembl Description Number Shared
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 316
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 40
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 1

Mineralocorticoid biosynthesis

Uniprot Swissprot Chembl Description Number Shared
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 316
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
C11B1_BOVIN P15150 CHEMBL2927 Cytochrome P450 11B1, Bovin 3 2 3 1
C11B1_RAT P15393 CHEMBL4970 Cytochrome P450 11B1, Rat 4 1 1 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 391 53 8 7

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
C11B1-1-E Cytochrome P450 11B1 (cluster #1 Of 2), Eukaryotic 155 17 9 7
C11B1-2-E Cytochrome P450 11B1 (cluster #2 Of 2), Eukaryotic 188 29 3 3
Uniprot Swissprot Chembl Description Number Shared
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 316
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 78
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 40
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 9
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 6
CP51A_HUMAN Q16850 CHEMBL3849 Cytochrome P450 51, Human 2
CP51A_RAT Q64654 CHEMBL4981 Cytochrome P450 51, Rat 2
C11B1_BOVIN P15150 CHEMBL2927 Cytochrome P450 11B1, Bovin 1
CP11A_RAT P14137 CHEMBL5246 Cytochrome P450 11A1, Rat 1
CP21A_HUMAN P08686 CHEMBL2759 Cytochrome P450 21, Human 1
CP24A_HUMAN Q07973 CHEMBL4521 Cytochrome P450 24A1, Human 1
CP7A1_RAT P18125 CHEMBL2339 Cytochrome P450 7A1, Rat 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 1
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HMOX1_RAT P06762 CHEMBL5035 Heme Oxygenase 1, Rat 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 1
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 1
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 1

Most Common Rings