Names
Compounds (648)
Reactome (3)
Related By:
Pathway (18)
Organism (1)
Gene (0)
Org. Clust. (1)
ChEMBL (71)
Rings (32)

Phosphodiesterase 3B, Human (648 Compounds)

Swissprot:: PDE3B_HUMAN
Stitch:: PDE3B_HUMAN
UniProt:: Q13370
ChEMBL:: CHEMBL290
Reactome:: REACT_23767; REACT_19327; REACT_1451
PDB:: 1SO2 (DOCK); 1SOJ (DOCK); PDE3B

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	648	28	26	35
Binding ≤ 1μM	428	14	13	25
Functional ≤ 10μM	63	4	2	2

Reactome ID	Description	Species
REACT_23767	cGMP effects	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens
REACT_1451	PDE3B signalling	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	37
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	2
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	37
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	37
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	22
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	705
PDE5A_HUMAN	O76074	CHEMBL1827	Phosphodiesterase 5A, Human	37
PDE9A_HUMAN	O76083	CHEMBL3535	Phosphodiesterase 9A, Human	2

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	1
AA2BR_HUMAN	P29275	CHEMBL255	Adenosine A2b Receptor, Human	1
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	37
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	2
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	37
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	37
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	22
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	705
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	114
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	107
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	109
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	115
PDE7A_HUMAN	Q13946	CHEMBL3012	Phosphodiesterase 7A, Human	3
PDE7B_HUMAN	Q9NP56	CHEMBL4716	Phosphodiesterase 7B, Human	3

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PDE3B_RAT	Q63085	CHEMBL3580	Phosphodiesterase 3B, Rat	4	1	4	1

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
PDE3B-1-E	Phosphodiesterase 3B (cluster #1 Of 2), Eukaryotic	453	19	22	27
PDE3B-2-E	Phosphodiesterase 3B (cluster #2 Of 2), Eukaryotic	199	9	7	8

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	705
PDE4D_HUMAN	Q08499	CHEMBL288	Phosphodiesterase 4D, Human	115
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	114
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	109
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	107
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	37
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	37
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	37
PDE1C_HUMAN	Q14123	CHEMBL4619	Phosphodiesterase 1C, Human	37
PDE5A_HUMAN	O76074	CHEMBL1827	Phosphodiesterase 5A, Human	37
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	33
O77823_PIG	O77823	CHEMBL3333	Phosphodiesterase 4A, Pig	24
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	22
Z50587	Z50587	CHEMBL372	Homo Sapiens	21
PDE4B_RAT	P14646	CHEMBL3382	Phosphodiesterase 4B, Rat	18
E1BN64_BOVIN	E1BN64	CHEMBL5129	Phosphodiesterase 3B, Bovin	17
PDE1B_RAT	Q01066	CHEMBL3665	Phosphodiesterase 1B, Rat	17
PDE4A_RAT	P54748	CHEMBL4964	Phosphodiesterase 4A, Rat	17
PDE4D_RAT	P14270	CHEMBL2712	Phosphodiesterase 4D, Rat	17
PDE1A_BOVIN	P14100	CHEMBL3774	Phosphodiesterase 1A, Bovin	12
PDE4C_RAT	P14644	CHEMBL4562	Phosphodiesterase 4C, Rat	12
CNCG_BOVIN	P22571	CHEMBL4606	Phosphodiesterase 6H, Bovin	7
CNRG_BOVIN	P04972	CHEMBL5111	Phosphodiesterase 6G, Bovin	7
PDE1B_BOVIN	Q01061	CHEMBL2650	Phosphodiesterase 1B, Bovin	7
PDE6A_BOVIN	P11541	CHEMBL3741	Phosphodiesterase 6A, Bovin	7
PDE6B_BOVIN	P23439	CHEMBL2713	Phosphodiesterase 6B, Bovin	7
PDE6C_BOVIN	P16586	CHEMBL3479	Phosphodiesterase 6C, Bovin	7
PDE6D_BOVIN	Q95142	CHEMBL5110	Phosphodiesterase 6D, Bovin	7
PDE5A_BOVIN	Q28156	CHEMBL3478	Phosphodiesterase 5A, Bovin	6
PDE5A_RAT	O54735	CHEMBL4567	Phosphodiesterase 5A, Rat	5
Q864F1_PIG	Q864F1	CHEMBL3634	Phosphodiesterase 5, Pig	5
THAS_HUMAN	P24557	CHEMBL1835	Thromboxane-A Synthase, Human	4
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	3
PDE1C_RAT	Q63421	CHEMBL2651	Phosphodiesterase 1C, Rat	3
PDE7A_HUMAN	Q13946	CHEMBL3012	Phosphodiesterase 7A, Human	3
PDE7A_RAT	O08593	CHEMBL3450	Phosphodiesterase 7A, Rat	3
PDE7B_HUMAN	Q9NP56	CHEMBL4716	Phosphodiesterase 7B, Human	3
Q9EPR9_RAT	Q9EPR9	CHEMBL2740	Phosphodiesterase 1A, Rat	3
Q9XSW7_PIG	Q9XSW7	CHEMBL3061	Phosphodiesterase 3A, Pig	3
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	3
CNCG_HUMAN	Q13956	CHEMBL2341	Phosphodiesterase 6H, Human	2
CNRG_HUMAN	P18545	CHEMBL2415	Phosphodiesterase 6G, Human	2
P2Y12_HUMAN	Q9H244	CHEMBL2001	Purinergic Receptor P2Y12, Human	2
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	2
PDE6A_HUMAN	P16499	CHEMBL3878	Phosphodiesterase 6A, Human	2
PDE6B_HUMAN	P35913	CHEMBL3659	Phosphodiesterase 6B, Human	2
PDE6C_HUMAN	P51160	CHEMBL3977	Phosphodiesterase 6C, Human	2
PDE6D_HUMAN	O43924	CHEMBL3860	Phosphodiesterase 6D, Human	2
PDE9A_HUMAN	O76083	CHEMBL3535	Phosphodiesterase 9A, Human	2
Q8VIE4_RAT	Q8VIE4	CHEMBL3386	Phosphodiesterase 7B, Rat	2
AA1R_BOVIN	P28190	CHEMBL4975	Adenosine A1 Receptor, Bovin	1
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	1
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	1
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	1
AA3R_RAT	P28647	CHEMBL3360	Adenosine A3 Receptor, Rat	1
C11B1_HUMAN	P15538	CHEMBL1908	Cytochrome P450 11B1, Human	1
C11B2_HUMAN	P19099	CHEMBL2722	Cytochrome P450 11B2, Human	1
PDE10_RAT	Q9QYJ6	CHEMBL6140	CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat	1
PDE2A_BOVIN	P14099	CHEMBL3477	Phosphodiesterase 2A, Bovin	1
PDE2A_RAT	Q01062	CHEMBL4650	Phosphodiesterase 2A, Rat	1
PDE3A_RAT	Q62865	CHEMBL2711	Phosphodiesterase 3A, Rat	1
PDE3B_RAT	Q63085	CHEMBL3580	Phosphodiesterase 3B, Rat	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
Z102333	Z102333	CHEMBL613633	Ileum	1
Z102380	Z102380	CHEMBL613680	Ileum	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1