UCSF

Phosphodiesterase 5A, Human (1,222 Compounds)

Swissprot:
PDE5A_HUMAN
Stitch:
PDE5A_HUMAN
UniProt:
O76074
ChEMBL:
CHEMBL1827
Reactome:
REACT_23767
PDB:
1RKP (DOCK)
1T9R (DOCK)
1T9S (DOCK)
1TBF (DOCK)
1UDT (DOCK)
1UDU (DOCK)
1UHO (DOCK)
1XOZ (DOCK)
1XP0 (DOCK)
2CHM (DOCK)
2H40 (DOCK)
2H42 (DOCK)
2H44 (DOCK)
2XSS (DOCK)
3B2R (DOCK)
3BJC (DOCK)
3HC8 (DOCK)
3HDZ (DOCK)
3JWQ (DOCK)
3JWR (DOCK)
3LFV (DOCK)
3MF0 (DOCK)
3SHY (DOCK)
3SHZ (DOCK)
3SIE (DOCK)
3TGE (DOCK)
3TGG (DOCK)
PDE5A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,222 69 13 7
Binding ≤ 1μM 979 34 7 5
Functional ≤ 10μM 8 2 1 1

Reactome Network (1)

Reactome ID Description Species
REACT_23767 cGMP effects Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 8
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 36
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 102
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 104
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 6
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 46
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 37
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE5A_BOVIN Q28156 CHEMBL3478 Phosphodiesterase 5A, Bovin 180 27 7 7
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 45 2 7 2

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PDE5A-1-E Phosphodiesterase 5A (cluster #1 Of 2), Eukaryotic 1,340 89 16 9
PDE5A-2-E Phosphodiesterase 5A (cluster #2 Of 2), Eukaryotic 94 8 6 2
Uniprot Swissprot Chembl Description Number Shared
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 104
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 103
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 102
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 79
CNCG_BOVIN P22571 CHEMBL4606 Phosphodiesterase 6H, Bovin 63
CNRG_BOVIN P04972 CHEMBL5111 Phosphodiesterase 6G, Bovin 63
PDE6A_BOVIN P11541 CHEMBL3741 Phosphodiesterase 6A, Bovin 63
PDE6B_BOVIN P23439 CHEMBL2713 Phosphodiesterase 6B, Bovin 63
PDE6C_BOVIN P16586 CHEMBL3479 Phosphodiesterase 6C, Bovin 63
PDE6D_BOVIN Q95142 CHEMBL5110 Phosphodiesterase 6D, Bovin 63
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 49
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 46
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 42
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 39
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 37
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 37
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 37
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 36
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 36
CNCG_HUMAN Q13956 CHEMBL2341 Phosphodiesterase 6H, Human 32
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 32
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 32
PDE5A_BOVIN Q28156 CHEMBL3478 Phosphodiesterase 5A, Bovin 22
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 20
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 20
Q9EPR9_RAT Q9EPR9 CHEMBL2740 Phosphodiesterase 1A, Rat 20
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 18
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 16
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 15
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 11
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 10
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 8
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 8
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 8
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 8
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 8
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 7
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 6
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 5
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 5
PDE6A_CANFA Q28263 CHEMBL5151 Rod CGMP-specific 3',5'-cyclic Phosphodiesterase Subunit Alpha, Canine 5
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 4
PDE2A_BOVIN P14099 CHEMBL3477 Phosphodiesterase 2A, Bovin 4
PDE7A_RAT O08593 CHEMBL3450 Phosphodiesterase 7A, Rat 4
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 4
E1BN64_BOVIN E1BN64 CHEMBL5129 Phosphodiesterase 3B, Bovin 3
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 3
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 3
Q8VIE4_RAT Q8VIE4 CHEMBL3386 Phosphodiesterase 7B, Rat 2
Z50590 Z50590 CHEMBL613488 Sus Scrofa 2
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 1
PDE2A_RAT Q01062 CHEMBL4650 Phosphodiesterase 2A, Rat 1
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1

Most Common Rings