ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,432)
Reactome (2)
Related By:
Pathway (18)
Organism (2)
Gene (0)
Org. Clust. (1)
ChEMBL (93)
Rings (39)

Phosphodiesterase 4D, Human (1,432 Compounds)

Swissprot:: PDE4D_HUMAN
Stitch:: PDE4D_HUMAN
UniProt:: Q08499
ChEMBL:: CHEMBL288
Reactome:: REACT_15334; REACT_19327
PDB:: 1E9K (DOCK); 1MKD (DOCK); 1OYN (DOCK); 1PTW (DOCK); 1Q9M (DOCK); 1TB7 (DOCK); 1TBB (DOCK); 1XOM (DOCK); 1XON (DOCK); 1XOQ (DOCK); 1XOR (DOCK); 1Y2B (DOCK); 1Y2C (DOCK); 1Y2D (DOCK); 1Y2E (DOCK); 1Y2K (DOCK); 1ZKN (DOCK); 2FM0 (DOCK); 2FM5 (DOCK); 2PW3 (DOCK); 2QYN (DOCK); 3G4G (DOCK); 3G4I (DOCK); 3G4K (DOCK); 3G4L (DOCK); 3G58 (DOCK); 3IAD (DOCK); 3IAK (DOCK); 3K4S (DOCK); 3SL3 (DOCK); 3SL4 (DOCK); 3SL5 (DOCK); 3SL6 (DOCK); 3SL8 (DOCK); 3V9B (DOCK); PDE4D

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,432	71	24	30
Binding ≤ 1μM	998	28	12	17
Functional ≤ 10μM	86	2	2	2

Reactome ID	Description	Species
REACT_15334	DARPP-32 events	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	1205
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	1248
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	1105

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	1
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	11
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	6
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	52
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	54
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	5
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	119
PDE3B_HUMAN	Q13370	CHEMBL290	Phosphodiesterase 3B, Human	115
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	1205
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	1248
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	1105
PDE7A_HUMAN	Q13946	CHEMBL3012	Phosphodiesterase 7A, Human	61
PDE7B_HUMAN	Q9NP56	CHEMBL4716	Phosphodiesterase 7B, Human	7
PDE8A_HUMAN	O60658	CHEMBL4640	Phosphodiesterase 8A, Human	1
PDE8B_HUMAN	O95263	CHEMBL4408	Phosphodiesterase 8B, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PDE4D_MOUSE	Q01063	CHEMBL3846	Phosphodiesterase 4D, Mouse	27	2	2	2
PDE4D_RAT	P14270	CHEMBL2712	Phosphodiesterase 4D, Rat	233	12	14	11

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
PDE4D-1-E	Phosphodiesterase 4D (cluster #1 Of 2), Eukaryotic	1,248	49	20	18
PDE4D-2-E	Phosphodiesterase 4D (cluster #2 Of 2), Eukaryotic	267	28	10	14

Uniprot	Swissprot	Chembl	Description	Number Shared
PDE4B_HUMAN	Q07343	CHEMBL275	Phosphodiesterase 4B, Human	1248
PDE4A_HUMAN	P27815	CHEMBL254	Phosphodiesterase 4A, Human	1205
PDE4C_HUMAN	Q08493	CHEMBL291	Phosphodiesterase 4C, Human	1105
PDE4B_RAT	P14646	CHEMBL3382	Phosphodiesterase 4B, Rat	177
PDE4D_RAT	P14270	CHEMBL2712	Phosphodiesterase 4D, Rat	160
PDE4A_RAT	P54748	CHEMBL4964	Phosphodiesterase 4A, Rat	159
PDE4C_RAT	P14644	CHEMBL4562	Phosphodiesterase 4C, Rat	136
PDE3A_HUMAN	Q14432	CHEMBL241	Phosphodiesterase 3A, Human	119
PDE3B_HUMAN	Q13370	CHEMBL290	Phosphodiesterase 3B, Human	115
PDE7A_HUMAN	Q13946	CHEMBL3012	Phosphodiesterase 7A, Human	61
O77823_PIG	O77823	CHEMBL3333	Phosphodiesterase 4A, Pig	55
PDE1B_HUMAN	Q01064	CHEMBL4425	Phosphodiesterase 1B, Human	54
PDE1A_HUMAN	P54750	CHEMBL3421	Phosphodiesterase 1A, Human	52
PDE1C_HUMAN	Q14123	CHEMBL4619	Phosphodiesterase 1C, Human	52
Z80566	Z80566	CHEMBL612794	U-937 (Histiocytic Lymphoma Cells)	51
PDE5A_HUMAN	O76074	CHEMBL1827	Phosphodiesterase 5A, Human	49
Q864F1_PIG	Q864F1	CHEMBL3634	Phosphodiesterase 5, Pig	27
PDE4A_MOUSE	O89084	CHEMBL2698	Phosphodiesterase 4A, Mouse	26
PDE4C_MOUSE	Q3UEI1	CHEMBL2550	Phosphodiesterase 4C, Mouse	26
PDE4D_MOUSE	Q01063	CHEMBL3846	Phosphodiesterase 4D, Mouse	26
Q8VBU5_MOUSE	Q8VBU5	CHEMBL2272	Phosphodiesterase 4B, Mouse	26
Z100081	Z100081	CHEMBL613107	PBMC (Peripheral Blood Mononuclear Cells)	24
PDE1A_BOVIN	P14100	CHEMBL3774	Phosphodiesterase 1A, Bovin	19
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	18
MMP2_HUMAN	P08253	CHEMBL333	Matrix Metalloproteinase-2, Human	16
MMP3_HUMAN	P08254	CHEMBL283	Matrix Metalloproteinase 3, Human	16
PDE1B_RAT	Q01066	CHEMBL3665	Phosphodiesterase 1B, Rat	16
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	16
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	16
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	16
PDE5A_BOVIN	Q28156	CHEMBL3478	Phosphodiesterase 5A, Bovin	15
MMP1_HUMAN	P03956	CHEMBL332	Matrix Metalloproteinase-1, Human	14
PDE1B_BOVIN	Q01061	CHEMBL2650	Phosphodiesterase 1B, Bovin	14
Q53I59_TRYCR	Q53I59	CHEMBL1681621	Cyclic Nucleotide Specific Phosphodiesterase, Trycr	14
Z50512	Z50512	CHEMBL369	Cavia Porcellus	14
AA1R_RAT	P25099	CHEMBL318	Adenosine A1 Receptor, Rat	11
PDE10_HUMAN	Q9Y233	CHEMBL4409	Phosphodiesterase 10A, Human	11
PDE1C_RAT	Q63421	CHEMBL2651	Phosphodiesterase 1C, Rat	8
Q9EPR9_RAT	Q9EPR9	CHEMBL2740	Phosphodiesterase 1A, Rat	8
E1BN64_BOVIN	E1BN64	CHEMBL5129	Phosphodiesterase 3B, Bovin	7
PDE7B_HUMAN	Q9NP56	CHEMBL4716	Phosphodiesterase 7B, Human	7
PDE11_HUMAN	Q9HCR9	CHEMBL2717	Phosphodiesterase 11A, Human	6
PDE2A_BOVIN	P14099	CHEMBL3477	Phosphodiesterase 2A, Bovin	6
PDE6A_HUMAN	P16499	CHEMBL3878	Phosphodiesterase 6A, Human	6
Z100709	Z100709	CHEMBL613821	Squirrel Monkey	6
CNCG_HUMAN	Q13956	CHEMBL2341	Phosphodiesterase 6H, Human	5
CNRG_HUMAN	P18545	CHEMBL2415	Phosphodiesterase 6G, Human	5
PDE2A_HUMAN	O00408	CHEMBL2652	Phosphodiesterase 2A, Human	5
PDE6B_HUMAN	P35913	CHEMBL3659	Phosphodiesterase 6B, Human	5
PDE6C_HUMAN	P51160	CHEMBL3977	Phosphodiesterase 6C, Human	5
PDE6D_HUMAN	O43924	CHEMBL3860	Phosphodiesterase 6D, Human	5
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	4
CNCG_BOVIN	P22571	CHEMBL4606	Phosphodiesterase 6H, Bovin	3
CNRG_BOVIN	P04972	CHEMBL5111	Phosphodiesterase 6G, Bovin	3
PDE6A_BOVIN	P11541	CHEMBL3741	Phosphodiesterase 6A, Bovin	3
PDE6B_BOVIN	P23439	CHEMBL2713	Phosphodiesterase 6B, Bovin	3
PDE6C_BOVIN	P16586	CHEMBL3479	Phosphodiesterase 6C, Bovin	3
PDE6D_BOVIN	Q95142	CHEMBL5110	Phosphodiesterase 6D, Bovin	3
PDE7A_RAT	O08593	CHEMBL3450	Phosphodiesterase 7A, Rat	3
Z100489	Z100489	CHEMBL614636	Eosinophils (Eosinophils)	3
Z50587	Z50587	CHEMBL372	Homo Sapiens	3
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
PDE9A_HUMAN	O76083	CHEMBL3535	Phosphodiesterase 9A, Human	2
Q9XSW7_PIG	Q9XSW7	CHEMBL3061	Phosphodiesterase 3A, Pig	2
TNFA_HUMAN	P01375	CHEMBL1825	TNF-alpha, Human	2
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	2
AA1R_BOVIN	P28190	CHEMBL4975	Adenosine A1 Receptor, Bovin	1
AA2AR_CAVPO	P46616	CHEMBL2605	Adenosine A2a Receptor, Guinea Pig	1
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	1
AA2AR_RAT	P30543	CHEMBL302	Adenosine A2a Receptor, Rat	1
AA2BR_RAT	P29276	CHEMBL2592	Adenosine A2b Receptor, Rat	1
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	1
AA3R_RAT	P28647	CHEMBL3360	Adenosine A3 Receptor, Rat	1
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1
BMP1_HUMAN	P13497	CHEMBL3898	Bone Morphogenetic Protein 1, Human	1
CLTR1_HUMAN	Q9Y271	CHEMBL1798	Cysteinyl Leukotriene Receptor 1, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
LOX5_RAT	P12527	CHEMBL312	Arachidonate 5-lipoxygenase, Rat	1
PDE10_RAT	Q9QYJ6	CHEMBL6140	CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat	1
PDE3A_RAT	Q62865	CHEMBL2711	Phosphodiesterase 3A, Rat	1
PDE3B_RAT	Q63085	CHEMBL3580	Phosphodiesterase 3B, Rat	1
PDE5A_RAT	O54735	CHEMBL4567	Phosphodiesterase 5A, Rat	1
PDE8A_HUMAN	O60658	CHEMBL4640	Phosphodiesterase 8A, Human	1
PDE8B_HUMAN	O95263	CHEMBL4408	Phosphodiesterase 8B, Human	1
Q8VIE4_RAT	Q8VIE4	CHEMBL3386	Phosphodiesterase 7B, Rat	1
S29A1_HUMAN	Q99808	CHEMBL1997	Equilibrative Nucleoside Transporter 1, Human	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
Z102191	Z102191	CHEMBL613397	Blood	1
Z102213	Z102213	CHEMBL613416	Blood	1
Z50590	Z50590	CHEMBL613488	Sus Scrofa	1