UCSF

Phosphodiesterase 1B, Rat (35 Compounds)

Swissprot:
PDE1B_RAT
Stitch:
PDE1B_RAT
UniProt:
Q01066
ChEMBL:
CHEMBL3665
Reactome:
REACT_260836
REACT_250690
REACT_246814
PDB:
Pde1b

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 35 7 3 3
Binding ≤ 1μM 15 4 1 1
Functional ≤ 10μM 10 4 2 2

Reactome Network (3)

Reactome ID Description Species
REACT_260836 Cam-PDE 1 activation Rattus norvegicus
REACT_250690 cGMP effects Rattus norvegicus
REACT_246814 G alpha (s) signalling events Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 1

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 5
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 2
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 77 7 4 4
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 181 21 8 8

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 28
Q9EPR9_RAT Q9EPR9 CHEMBL2740 Phosphodiesterase 1A, Rat 28
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 20
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 17
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 17
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 16
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 15
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 15
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 15
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 9
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 7
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 7
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 7
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 5
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 4
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 3
PDE2A_BOVIN P14099 CHEMBL3477 Phosphodiesterase 2A, Bovin 3
CNCG_BOVIN P22571 CHEMBL4606 Phosphodiesterase 6H, Bovin 2
CNCG_HUMAN Q13956 CHEMBL2341 Phosphodiesterase 6H, Human 2
CNRG_BOVIN P04972 CHEMBL5111 Phosphodiesterase 6G, Bovin 2
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 2
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 2
PDE5A_BOVIN Q28156 CHEMBL3478 Phosphodiesterase 5A, Bovin 2
PDE6A_BOVIN P11541 CHEMBL3741 Phosphodiesterase 6A, Bovin 2
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 2
PDE6B_BOVIN P23439 CHEMBL2713 Phosphodiesterase 6B, Bovin 2
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 2
PDE6C_BOVIN P16586 CHEMBL3479 Phosphodiesterase 6C, Bovin 2
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 2
PDE6D_BOVIN Q95142 CHEMBL5110 Phosphodiesterase 6D, Bovin 2
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 2
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 2
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
E1BN64_BOVIN E1BN64 CHEMBL5129 Phosphodiesterase 3B, Bovin 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 1
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 1
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 1
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 1
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 1
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
Z100267 Z100267 CHEMBL612409 Anti-estrogen Binding Site (AEBS) 1
Z102333 Z102333 CHEMBL613633 Ileum 1
Z102380 Z102380 CHEMBL613680 Ileum 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1