UCSF

PBMC (Peripheral Blood Mononuclear Cells) (28 Compounds)

Swissprot:
Z100081
Stitch:
Z100081
UniProt:
Z100081
ChEMBL:
CHEMBL613107

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 28 4 4 6
Binding ≤ 1μM 14 4 4 6
Functional ≤ 10μM 1,145 58 24 35
ADME/T ≤ 10μM 83 9 9 5

Reactome Network (0)

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 102
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 101
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 101
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 101
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 65
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 47
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 29
Z80295 Z80295 CHEMBL388 MT4 (Lymphocytes) 29
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 26
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 24
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 24
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 24
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 24
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 21
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 18
Z50587 Z50587 CHEMBL372 Homo Sapiens 17
GCR_RAT P06536 CHEMBL3368 Glucocorticoid Receptor, Rat 11
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 11
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 10
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 10
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 9
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 8
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 8
Z80076 Z80076 CHEMBL614548 CEM-SS (T-cell Leukemia) 7
Z80110 Z80110 CHEMBL613507 CV-1 (Kidney Cells) 7
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 6
Z50658 Z50658 CHEMBL380 Human Immunodeficiency Virus 2 6
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 6
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 6
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 5
Z100201 Z100201 CHEMBL612422 Splenocytes (Spleen Cells) 5
Z50594 Z50594 CHEMBL375 Mus Musculus 5
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 5
ADA17_HUMAN P78536 CHEMBL3706 ADAM17, Human 4
Z50512 Z50512 CHEMBL369 Cavia Porcellus 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
Z50677 Z50677 CHEMBL613758 Human Immunodeficiency Virus 4
Z80132 Z80132 CHEMBL614293 EL4 (Thymoma Cells) 4
Z80291 Z80291 CHEMBL614181 MRC5 (Embryonic Lung Fibroblast Cells) 4
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 4
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 4
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 4
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 4
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 3
TLR7_HUMAN Q9NYK1 CHEMBL5936 Toll-like Receptor 7, Human 3
Z102116 Z102116 CHEMBL613159 Toxoplasma Gondii RH 3
Z50472 Z50472 CHEMBL612888 Toxoplasma Gondii 3
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 3
Z50606 Z50606 CHEMBL613497 Hepatitis B Virus 3
Z80052 Z80052 CHEMBL614533 C8166 (Leukemic T-cells) 3
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 3
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 3
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 3
Z81011 Z81011 CHEMBL614840 Human Cell Lines 3
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 3
Z81338 Z81338 CHEMBL614309 T-cells 3
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 2
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 2
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 2
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 2
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 2
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 2
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 2
NFAC1_HUMAN O95644 CHEMBL3876 Nuclear Factor Of Activated T-cells Cytoplasmic 1, Human 2
NFAC2_HUMAN Q13469 CHEMBL4120 Nuclear Factor Of Activated T-cells Cytoplasmic 2, Human 2
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 2
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 2
PDE4A_MOUSE O89084 CHEMBL2698 Phosphodiesterase 4A, Mouse 2
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 2
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 2
PDE4C_MOUSE Q3UEI1 CHEMBL2550 Phosphodiesterase 4C, Mouse 2
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 2
PDE4D_MOUSE Q01063 CHEMBL3846 Phosphodiesterase 4D, Mouse 2
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 2
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 2
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 2
Q8VBU5_MOUSE Q8VBU5 CHEMBL2272 Phosphodiesterase 4B, Mouse 2
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 2
Z100489 Z100489 CHEMBL614636 Eosinophils (Eosinophils) 2
Z102213 Z102213 CHEMBL613416 Blood 2
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 2
Z50602 Z50602 CHEMBL377 Human Herpesvirus 1 2
Z80002 Z80002 CHEMBL614075 1A9 (Ovarian Adenocarcinoma Cells) 2
Z80005 Z80005 CHEMBL614077 3T3 (Fibroblast Cells) 2
Z80035 Z80035 CHEMBL381 B16 (Melanoma Cells) 2
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 2
Z80178 Z80178 CHEMBL614040 J774.A1 (Macrophage Cells) 2
Z80253 Z80253 CHEMBL614342 MEF (Embryonic Fibroblast Cells) 2
Z80523 Z80523 CHEMBL614944 SW1353 2
Z80583 Z80583 CHEMBL391 Vero (Kidney Cells) 2
Z80704 Z80704 CHEMBL614358 BJ (Foreskin Fibroblast Cells) 2
Z80865 Z80865 CHEMBL612253 GHOST CXCR4 Cell Line 2
Z80901 Z80901 CHEMBL614392 HaCaT (Keratinocytes) 2
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81135 Z81135 CHEMBL614793 L6 (Skeletal Muscle Myoblast Cells) 2
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 2
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
ITAL_HUMAN P20701 CHEMBL1803 Leukocyte Adhesion Glycoprotein LFA-1 Alpha, Human 1
ITB2_HUMAN P05107 CHEMBL3631 Integrin Beta-2, Human 1
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
KPCB_HUMAN P05771 CHEMBL3045 Protein Kinase C Beta, Human 1
MCR_HUMAN P08235 CHEMBL1994 Mineralocorticoid Receptor, Human 1
NEMO_HUMAN Q9Y6K9 CHEMBL4967 NF-kappa-B Essential Modulator, Human 1
PGFRA_MOUSE P26618 CHEMBL3466 Platelet-derived Growth Factor Receptor Alpha, Mouse 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PGFRB_MOUSE P05622 CHEMBL2749 Platelet-derived Growth Factor Receptor Beta, Mouse 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
VDR_HUMAN P11473 CHEMBL1977 Vitamin D Receptor, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
Z101829 Z101829 CHEMBL612769 HBV Genotype D 1
Z101839 Z101839 CHEMBL612775 HIV-1 M:B_Lai 1
Z102020 Z102020 CHEMBL613016 Porcine Endogenous Retrovirus 1
Z102306 Z102306 CHEMBL613606 Aorta 1
Z103203 Z103203 CHEMBL1075388 A375 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z50038 Z50038 CHEMBL612328 Plasmodium Yoelii Yoelii 1
Z50459 Z50459 CHEMBL367 Leishmania Donovani 1
Z50501 Z50501 CHEMBL613109 Gallus Gallus 1
Z50518 Z50518 CHEMBL613124 Human Herpesvirus 4 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z50609 Z50609 CHEMBL613499 Simian Immunodeficiency Virus 1
Z50612 Z50612 CHEMBL613501 Moloney Murine Sarcoma Virus 1
Z50614 Z50614 CHEMBL613551 Human T-lymphotropic Virus 1 1
Z50643 Z50643 CHEMBL379 Hepatitis C Virus 1
Z50664 Z50664 CHEMBL613748 Rauscher Murine Leukemia Virus 1
Z50681 Z50681 CHEMBL613761 Duck Hepatitis B Virus 1
Z50737 Z50737 CHEMBL612359 Human Immunodeficiency Virus 3 1
Z50755 Z50755 CHEMBL612370 Anas Sp. 1
Z80068 Z80068 CHEMBL614542 CCRF-SB (Lymphoblastic Leukemia Cells) 1
Z80071 Z80071 CHEMBL614028 CEM-0 (T-cell Leukemia) 1
Z80073 Z80073 CHEMBL614545 CEM-c113 1
Z80079 Z80079 CHEMBL614549 CEM-V 1
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 1
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 1
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 1
Z80294 Z80294 CHEMBL614184 MT2 (Lymphocytes) 1
Z80384 Z80384 CHEMBL614233 PBL (Peripheral Blood Lymphocytes) 1
Z80437 Z80437 CHEMBL614885 RWLeu4 1
Z80516 Z80516 CHEMBL614940 SUP-T1 1
Z80683 Z80683 CHEMBL614272 ATH8 Cell Line 1
Z80688 Z80688 CHEMBL614797 B(EBV+) Cell Line 1
Z80721 Z80721 CHEMBL614366 BxT Cell Line 1
Z80737 Z80737 CHEMBL614372 C3H/3T3 (Embryonic Fibroblast Cells) 1
Z80760 Z80760 CHEMBL614779 CFU-GM Cell Line 1
Z80800 Z80800 CHEMBL614725 MIA PaCa-2 (Pancreatic Carcinoma Cells) 1
Z80885 Z80885 CHEMBL614507 BEND (Brain Endothelial Cells) 1
Z80897 Z80897 CHEMBL614806 H9 (T-lymphoid Cells) 1
Z80947 Z80947 CHEMBL614820 Hepatoblastoma Cell Line 1
Z80949 Z80949 CHEMBL614821 Hepatoma Cell Line 1
Z80954 Z80954 CHEMBL614071 HFF (Foreskin Fibroblasts) 1
Z81117 Z81117 CHEMBL613995 Keratinocytes (Keratinocytes) 1
Z81223 Z81223 CHEMBL614115 M Cell Line 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1
Z81264 Z81264 CHEMBL614074 V79 (Lung Fibroblasts) 1
Z81298 Z81298 CHEMBL614846 PE Cell Line 1