UCSF

C-X-C Chemokine Receptor Type 4, Human (106 Compounds)

Swissprot:
CXCR4_HUMAN
Stitch:
CXCR4_HUMAN
UniProt:
P61073
ChEMBL:
CHEMBL2107
Reactome:
REACT_6903
REACT_15344
REACT_19231
PDB:
2K03 (DOCK)
2K04 (DOCK)
2K05 (DOCK)
3ODU (DOCK)
3OE0 (DOCK)
3OE6 (DOCK)
3OE8 (DOCK)
3OE9 (DOCK)
CXCR4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 106 4 1 1
Binding ≤ 1μM 87 4 1 1
Functional ≤ 10μM 120 6 3 3

Reactome Network (3)

Reactome ID Description Species
REACT_6903 Binding and entry of HIV virion Homo sapiens
REACT_15344 Chemokine receptors bind chemokines Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 3
ENV_HV1H2 P04578 CHEMBL3520 Envelope Polyprotein GP160, Hv1h2 1

Chemokine receptors bind chemokines

Uniprot Swissprot Chembl Description Number Shared
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 1
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 1
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 3
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 1

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 1
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 1
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 3
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CXCR4_RAT O08565 CHEMBL5556 C-X-C Chemokine Receptor Type 4, Rat 4 1 1 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 217 2 1 1
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 470 6 0 0
CXCR3_HUMAN P49682 CHEMBL4441 C-X-C Chemokine Receptor Type 3, Human 557 10 0 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CXCR4-1-E C-X-C Chemokine Receptor Type 4 (cluster #1 Of 2), Eukaryotic 84 6 1 1
CXCR4-2-E C-X-C Chemokine Receptor Type 4 (cluster #2 Of 2), Eukaryotic 25 0 0 0
Uniprot Swissprot Chembl Description Number Shared
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 115
CXCR4_RAT O08565 CHEMBL5556 C-X-C Chemokine Receptor Type 4, Rat 5
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 3
Z50658 Z50658 CHEMBL380 Human Immunodeficiency Virus 2 3
Z80076 Z80076 CHEMBL614548 CEM-SS (T-cell Leukemia) 3
Z80295 Z80295 CHEMBL388 MT4 (Lymphocytes) 3
Q72547_9HIV1 Q72547 CHEMBL247 Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 2
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 2
Z50677 Z50677 CHEMBL613758 Human Immunodeficiency Virus 2
Z80052 Z80052 CHEMBL614533 C8166 (Leukemic T-cells) 2
Z80294 Z80294 CHEMBL614184 MT2 (Lymphocytes) 2
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 2
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 1
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 1
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 1
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 1
CXCR4_MACMU P79394 CHEMBL1250366 C-X-C Chemokine Receptor Type 4, Macmu 1
CXCR4_MOUSE P70658 CHEMBL1250365 C-X-C Chemokine Receptor Type 4, Mouse 1
ENV_HV1H2 P04578 CHEMBL3520 Envelope Polyprotein GP160, Hv1h2 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
Z102020 Z102020 CHEMBL613016 Porcine Endogenous Retrovirus 1
Z50459 Z50459 CHEMBL367 Leishmania Donovani 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50606 Z50606 CHEMBL613497 Hepatitis B Virus 1
Z50609 Z50609 CHEMBL613499 Simian Immunodeficiency Virus 1
Z50624 Z50624 CHEMBL613715 Human Adenovirus Type 2 1
Z50664 Z50664 CHEMBL613748 Rauscher Murine Leukemia Virus 1
Z50737 Z50737 CHEMBL612359 Human Immunodeficiency Virus 3 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80071 Z80071 CHEMBL614028 CEM-0 (T-cell Leukemia) 1
Z80073 Z80073 CHEMBL614545 CEM-c113 1
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 1
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 1
Z80384 Z80384 CHEMBL614233 PBL (Peripheral Blood Lymphocytes) 1
Z80516 Z80516 CHEMBL614940 SUP-T1 1
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 1
Z80683 Z80683 CHEMBL614272 ATH8 Cell Line 1
Z80688 Z80688 CHEMBL614797 B(EBV+) Cell Line 1
Z80721 Z80721 CHEMBL614366 BxT Cell Line 1
Z80737 Z80737 CHEMBL614372 C3H/3T3 (Embryonic Fibroblast Cells) 1
Z80760 Z80760 CHEMBL614779 CFU-GM Cell Line 1
Z80865 Z80865 CHEMBL612253 GHOST CXCR4 Cell Line 1
Z80897 Z80897 CHEMBL614806 H9 (T-lymphoid Cells) 1
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81223 Z81223 CHEMBL614115 M Cell Line 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 1

Most Common Rings