Names
Compounds (470)
Reactome (2)
Related By:
Pathway (14)
Organism (0)
Gene (3)
Org. Clust. (1)
ChEMBL (38)
Rings (50)

Interleukin-8 Receptor B, Human (470 Compounds)

Swissprot:: CXCR2_HUMAN
Stitch:: CXCR2_HUMAN
UniProt:: P25025
ChEMBL:: CHEMBL2434
Reactome:: REACT_15344; REACT_19231

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	470	6	0	0
Binding ≤ 1μM	406	6	0	0
Functional ≤ 10μM	64	5	5	5

Reactome ID	Description	Species
REACT_15344	Chemokine receptors bind chemokines	Homo sapiens
REACT_19231	G alpha (i) signalling events	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	2
CCR2_HUMAN	P41597	CHEMBL4015	C-C Chemokine Receptor Type 2, Human	2
CCR3_HUMAN	P51677	CHEMBL3473	C-C Chemokine Receptor Type 3, Human	2
CCR4_HUMAN	P51679	CHEMBL2414	C-C Chemokine Receptor Type 4, Human	1
CCR5_HUMAN	P51681	CHEMBL274	C-C Chemokine Receptor Type 5, Human	3
CCR7_HUMAN	P32248	CHEMBL4594	C-C Chemokine Receptor Type 7, Human	1
CCR9_HUMAN	P51686	CHEMBL5815	C-C Chemokine Receptor Type 9, Human	1
CXCR1_HUMAN	P25024	CHEMBL4029	Interleukin-8 Receptor A, Human	222
CXCR4_HUMAN	P61073	CHEMBL2107	C-X-C Chemokine Receptor Type 4, Human	1
IL8_HUMAN	P10145	CHEMBL2157	Interleukin-8, Human	2

G alpha (i) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	2
CCR2_HUMAN	P41597	CHEMBL4015	C-C Chemokine Receptor Type 2, Human	2
CCR3_HUMAN	P51677	CHEMBL3473	C-C Chemokine Receptor Type 3, Human	2
CCR4_HUMAN	P51679	CHEMBL2414	C-C Chemokine Receptor Type 4, Human	1
CCR5_HUMAN	P51681	CHEMBL274	C-C Chemokine Receptor Type 5, Human	3
CCR7_HUMAN	P32248	CHEMBL4594	C-C Chemokine Receptor Type 7, Human	1
CCR9_HUMAN	P51686	CHEMBL5815	C-C Chemokine Receptor Type 9, Human	1
CXCR1_HUMAN	P25024	CHEMBL4029	Interleukin-8 Receptor A, Human	222
CXCR4_HUMAN	P61073	CHEMBL2107	C-X-C Chemokine Receptor Type 4, Human	1
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
IL8_HUMAN	P10145	CHEMBL2157	Interleukin-8, Human	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
CXCR1_HUMAN	P25024	CHEMBL4029	Interleukin-8 Receptor A, Human	217	2	1	1
CXCR3_HUMAN	P49682	CHEMBL4441	C-X-C Chemokine Receptor Type 3, Human	557	10	0	1
CXCR4_HUMAN	P61073	CHEMBL2107	C-X-C Chemokine Receptor Type 4, Human	106	4	1	1

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
CXCR2-1-E	Interleukin-8 Receptor B (cluster #1 Of 2), Eukaryotic	434	5	0	0
CXCR2-2-E	Interleukin-8 Receptor B (cluster #2 Of 2), Eukaryotic	43	1	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
CXCR1_HUMAN	P25024	CHEMBL4029	Interleukin-8 Receptor A, Human	222
CXCR2_RABIT	P35344	CHEMBL1075198	C-X-C Chemokine Receptor Type 2, Rabit	6
CCR5_HUMAN	P51681	CHEMBL274	C-C Chemokine Receptor Type 5, Human	3
Z80088	Z80088	CHEMBL613853	CHO (Ovarian Cells)	3
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	2
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	2
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	2
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	2
CCR1_HUMAN	P32246	CHEMBL2413	C-C Chemokine Receptor Type 1, Human	2
CCR2_HUMAN	P41597	CHEMBL4015	C-C Chemokine Receptor Type 2, Human	2
CCR3_HUMAN	P51677	CHEMBL3473	C-C Chemokine Receptor Type 3, Human	2
CCR3_MOUSE	P51678	CHEMBL3406	C-C Chemokine Receptor Type 3, Mouse	2
CCR3_RAT	O54814	CHEMBL3928	C-C Chemokine Receptor Type 3, Rat	2
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	2
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	2
PGH1_HUMAN	P23219	CHEMBL221	Cyclooxygenase-1, Human	2
PGH1_MOUSE	P22437	CHEMBL2649	Cyclooxygenase-1, Mouse	2
PGH2_HUMAN	P35354	CHEMBL230	Cyclooxygenase-2, Human	2
PGH2_MOUSE	Q05769	CHEMBL4321	Cyclooxygenase-2, Mouse	2
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	2
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	2
SC6A3_BOVIN	P27922	CHEMBL2986	Dopamine Transporter, Bovin	2
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	2
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	2
SC6A4_MOUSE	Q60857	CHEMBL4642	Serotonin Transporter, Mouse	2
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	2
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	1
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	1
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	1
CCR4_HUMAN	P51679	CHEMBL2414	C-C Chemokine Receptor Type 4, Human	1
CCR7_HUMAN	P32248	CHEMBL4594	C-C Chemokine Receptor Type 7, Human	1
CCR9_HUMAN	P51686	CHEMBL5815	C-C Chemokine Receptor Type 9, Human	1
CXCR4_HUMAN	P61073	CHEMBL2107	C-X-C Chemokine Receptor Type 4, Human	1
CXCR4_RAT	O08565	CHEMBL5556	C-X-C Chemokine Receptor Type 4, Rat	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
PAI1_HUMAN	P05121	CHEMBL3475	Plasminogen Activator Inhibitor-1, Human	1
Z100521	Z100521	CHEMBL612572	L1.2 (Pre-B Cells)	1
Z50587	Z50587	CHEMBL372	Homo Sapiens	1