UCSF

Interleukin-8, Human (26 Compounds)

Swissprot:
IL8_HUMAN
Stitch:
IL8_HUMAN
UniProt:
P10145
ChEMBL:
CHEMBL2157
Reactome:
REACT_18355
REACT_15344
REACT_19231
REACT_14819
REACT_169168
PDB:
1ICW (DOCK)
1IKL (DOCK)
1IKM (DOCK)
1IL8 (DOCK)
1ILP (DOCK)
1ILQ (DOCK)
1QE6 (DOCK)
1ROD (DOCK)
2IL8 (DOCK)
3IL8 (DOCK)
IL8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 26 6 5 5
Binding ≤ 1μM 26 6 5 5
Uniprot Swissprot Chembl Description Number Shared
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 3
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 3
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
IL2RA_HUMAN P01589 CHEMBL1778 Interleukin-2 Receptor Alpha Chain, Human 6 1 0 1
IL2RB_HUMAN P14784 CHEMBL3276 Interleukin-2 Receptor Beta Chain, Human 2 0 0 1
IL2RG_HUMAN P31785 CHEMBL2166 Interleukin-2 Receptor Gamma Chain, Human 0 0 0 0
IL2_HUMAN P60568 CHEMBL5880 Interleukin-2, Human 1 0 0 1
ILK_HUMAN Q13418 CHEMBL5247 Serine/threonine-protein Kinase ILK-1, Human 1 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 4
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 4
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 4
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 3
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 3
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 3
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 2
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 2
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 2
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1
ALBU_BOVIN P02769 CHEMBL3728 Serum Albumin, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 1
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 1
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
S22A6_MOUSE Q8VC69 CHEMBL5653 Solute Carrier Family 22 Member 6, Mouse 1
S22AK_MOUSE Q80UJ1 CHEMBL5269 Solute Carrier Family 22 Member 20, Mouse 1