UCSF

Interleukin-8 Receptor A, Human (217 Compounds)

Swissprot:
CXCR1_HUMAN
Stitch:
CXCR1_HUMAN
UniProt:
P25024
ChEMBL:
CHEMBL4029
Reactome:
REACT_15344
REACT_19231
PDB:
1ILP (DOCK)
1ILQ (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 217 2 1 1
Binding ≤ 1μM 153 2 1 1
Functional ≤ 10μM 44 5 5 5

Reactome Network (2)

Reactome ID Description Species
REACT_15344 Chemokine receptors bind chemokines Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 2
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 2
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 222
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 3

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 2
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 2
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 222
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 470 6 0 0
CXCR3_HUMAN P49682 CHEMBL4441 C-X-C Chemokine Receptor Type 3, Human 557 10 0 1
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 106 4 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 222
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 3
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 3
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 3
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 2
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 2
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 2
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 2
CCR3_MOUSE P51678 CHEMBL3406 C-C Chemokine Receptor Type 3, Mouse 2
CCR3_RAT O54814 CHEMBL3928 C-C Chemokine Receptor Type 3, Rat 2
CCR5_HUMAN P51681 CHEMBL274 C-C Chemokine Receptor Type 5, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 2
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 1
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 1
PAI1_HUMAN P05121 CHEMBL3475 Plasminogen Activator Inhibitor-1, Human 1
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 1
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 1
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 1
Z100521 Z100521 CHEMBL612572 L1.2 (Pre-B Cells) 1

Most Common Rings