UCSF

Cyclooxygenase-1, Mouse (37 Compounds)

Swissprot:
PGH1_MOUSE
Stitch:
PGH1_MOUSE
UniProt:
P22437
ChEMBL:
CHEMBL2649
Reactome:
REACT_263041
REACT_188623
PDB:
Ptgs1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 37 7 3 3
Binding ≤ 1μM 28 3 2 2
Functional ≤ 10μM 14 3 3 3

Reactome Network (2)

Reactome ID Description Species
REACT_263041 COX reactions Mus musculus
REACT_188623 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Mus musculus
Uniprot Swissprot Chembl Description Number Shared
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 48
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 100 16 12 12
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 969 95 65 44
PGH1_RABIT O97554 CHEMBL3334 Cyclooxygenase-1, Rabit 9 1 1 1
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 252 34 20 18
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 198 36 21 23
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 250 33 15 9

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
PGH1-1-E Cyclooxygenase-1 (cluster #1 Of 6), Eukaryotic 834 44 17 19
PGH1-2-E Cyclooxygenase-1 (cluster #2 Of 6), Eukaryotic 351 70 53 38
PGH1-3-E Cyclooxygenase-1 (cluster #3 Of 6), Eukaryotic 70 17 5 3
PGH1-4-E Cyclooxygenase-1 (cluster #4 Of 6), Eukaryotic 47 7 6 3
PGH1-5-E Cyclooxygenase-1 (cluster #5 Of 6), Eukaryotic 108 5 6 0
PGH1-6-E Cyclooxygenase-1 (cluster #6 Of 6), Eukaryotic 61 7 6 7
Uniprot Swissprot Chembl Description Number Shared
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 48
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 11
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 8
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 8
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 5
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 3
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 2
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 2
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 2
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 2
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
B5SU02_9CNID B5SU02 CHEMBL1075028 Alpha Carbonic Anhydrase, 9cnid 1
C0IX24_9CNID C0IX24 CHEMBL1649055 Carbonic Anhydrase, 9cnid 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CAH_METTE P40881 CHEMBL3932 Carbonic Anhydrase, Mette 1
CAN_YEAST P53615 CHEMBL5931 Carbonic Anhydrase, Yeast 1
COX2_SHEEP O78750 CHEMBL1250404 Cytochrome C Oxidase Subunit 2, Sheep 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CYNT_MYCTU O53573 CHEMBL6068 Carbonic Anhydrase, Myctu 1
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 1
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
Q5AJ71_CANAL Q5AJ71 CHEMBL5337 Carbonic Anhydrase, Canal 1
Q8HZR1_CANFA Q8HZR1 CHEMBL4133 Cyclooxygenase-1, Canine 1
Q8SPQ9_CANFA Q8SPQ9 CHEMBL4033 Cyclooxygenase-2, Canine 1
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 1
Z102213 Z102213 CHEMBL613416 Blood 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1