UCSF

Arachidonate 5-lipoxygenase, Human (952 Compounds)

Swissprot:
LOX5_HUMAN
Stitch:
LOX5_HUMAN
UniProt:
P09917
ChEMBL:
CHEMBL215
Reactome:
REACT_150209
REACT_150420
REACT_150320
PDB:
2ABV (DOCK)
3O8Y (DOCK)
ALOX5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 952 85 36 16
Binding ≤ 1μM 629 51 18 8
Functional ≤ 10μM 777 43 21 14

Reactome Network (3)

Reactome ID Description Species
REACT_150209 Synthesis of 5-eicosatetraenoic acids Homo sapiens
REACT_150420 Synthesis of Leukotrienes (LT) and Eoxins (EX) Homo sapiens
REACT_150320 Synthesis of Lipoxins (LX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 44

Synthesis of Leukotrienes (LT) and Eoxins (EX)

Uniprot Swissprot Chembl Description Number Shared
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 44
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 2
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 9
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 2

Synthesis of Lipoxins (LX)

Uniprot Swissprot Chembl Description Number Shared
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 44
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 9
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 57 11 1 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1,236 82 35 22
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 87 23 11 5
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 105 24 13 5

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
LOX5-1-E Arachidonate 5-lipoxygenase (cluster #1 Of 6), Eukaryotic 1,382 99 38 23
LOX5-2-E Arachidonate 5-lipoxygenase (cluster #2 Of 6), Eukaryotic 64 8 6 2
LOX5-3-E Arachidonate 5-lipoxygenase (cluster #3 Of 6), Eukaryotic 17 1 0 0
LOX5-4-E Arachidonate 5-lipoxygenase (cluster #4 Of 6), Eukaryotic 260 19 8 5
LOX5-5-E Arachidonate 5-lipoxygenase (cluster #5 Of 6), Eukaryotic 119 11 4 0
LOX5-6-E Arachidonate 5-lipoxygenase (cluster #6 Of 6), Eukaryotic 309 24 8 4
Uniprot Swissprot Chembl Description Number Shared
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 210
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 85
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 84
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 83
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 65
Z50587 Z50587 CHEMBL372 Homo Sapiens 44
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 34
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 25
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 22
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 21
LX12L_RAT Q02759 CHEMBL2741 Arachidonate 12-lipoxygenase, Rat 20
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 18
Z100751 Z100751 CHEMBL613706 PMNL (Polymorphonuclear Leukocytes) 17
Z50512 Z50512 CHEMBL369 Cavia Porcellus 13
LOX15_RABIT P12530 CHEMBL4358 Arachidonate 15-lipoxygenase, Rabit 12
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 11
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 10
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 9
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 9
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 9
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 8
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 8
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 8
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 7
Z50588 Z50588 CHEMBL373 Canis Familiaris 6
Z80419 Z80419 CHEMBL614772 RBL-1 (Basophilic Leukemia Cells) 6
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 5
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 5
Z50594 Z50594 CHEMBL375 Mus Musculus 5
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 4
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 4
Q9BEG3_BOVIN Q9BEG3 CHEMBL2980 Arachidonate 5-lipoxygenase, Bovin 4
IGF1R_HUMAN P08069 CHEMBL1957 Insulin-like Growth Factor I Receptor, Human 3
LOX1_SOYBN P08170 CHEMBL4586 Seed Lipoxygenase-1, Soybn 3
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 3
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 3
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 3
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 3
Z100274 Z100274 CHEMBL614676 Liposome 3
Z102116 Z102116 CHEMBL613159 Toxoplasma Gondii RH 3
Z50472 Z50472 CHEMBL612888 Toxoplasma Gondii 3
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 3
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 3
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 3
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 2
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 2
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 2
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 2
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 2
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 2
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 2
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 2
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 2
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 2
DHB2_HUMAN P37059 CHEMBL2789 Estradiol 17-beta-dehydrogenase 2, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 2
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 2
LOX12_PIG P16469 CHEMBL2381 Arachidonate 12-lipoxygenase, Pig 2
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 2
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 2
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 2
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 2
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 2
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 2
PGES2_HUMAN Q9H7Z7 CHEMBL4411 Prostaglandin E Synthase 2, Human 2
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 2
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 2
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 2
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 2
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 2
Z102213 Z102213 CHEMBL613416 Blood 2
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 2
Z80523 Z80523 CHEMBL614944 SW1353 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5NTD_RAT P21588 CHEMBL1075214 5'-nucleotidase, Rat 1
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 1
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 1
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 1
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 1
AHR_HUMAN P35869 CHEMBL3201 Aryl Hydrocarbon Receptor, Human 1
AK1A1_RAT P51635 CHEMBL3871 Aldehyde Reductase, Rat 1
AK1CL_MOUSE Q91WR5 CHEMBL1075270 Aldo-keto Reductase Family 1 Member C21, Mouse 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 1
AMPH_ECOLI P0AD70 CHEMBL4413 Penicillin-binding Protein AmpH, Ecoli 1
AOFA_BOVIN P21398 CHEMBL3254 Monoamine Oxidase A, Bovin 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH13_MOUSE Q9D6N1 CHEMBL2186 Carbonic Anhydrase XIII, Mouse 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH3_HUMAN P07451 CHEMBL2885 Carbonic Anhydrase III, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 1
CETP_HUMAN P11597 CHEMBL3572 Cholesteryl Ester Transfer Protein, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 1
DHB3_RAT O54939 CHEMBL1075158 Testosterone 17-beta-dehydrogenase 3, Rat 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
MDH_THETH P10584 CHEMBL4255 Malate Dehydrogenase, Theth 1
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 1
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1
MTSI_SPISQ P15840 CHEMBL4373 CpG DNA Methylase, Spisq 1
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 1
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
P85B_HUMAN O00459 CHEMBL4437 PI3-kinase P85-beta Subunit, Human 1
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PPCE_HUMAN P48147 CHEMBL3202 Prolyl Endopeptidase, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 1
Q8HY88_BOVIN Q8HY88 CHEMBL1075183 Potassium Channel Subfamily K Member 2, Bovin 1
Q965D5_PLAFA Q965D5 CHEMBL4150 Enoyl-acyl-carrier Protein Reductase, Plafa 1
Q965D7_PLAFA Q965D7 CHEMBL4512 Fatty Acid Synthase, Plafa 1
R1AB_CVHSA P0C6X7 CHEMBL5118 Replicase Polyprotein 1ab, Cvhsa 1
REST_BORBU O50979 CHEMBL1667698 Telomere Resolvase ResT, Borbu 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
TRY1_HUMAN P07477 CHEMBL209 Trypsin I, Human 1
TTHY_HUMAN P02766 CHEMBL3194 Transthyretin, Human 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1
Z102178 Z102178 CHEMBL613694 Liver Microsomes 1
Z102342 Z102342 CHEMBL613642 Liver 1
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 1
Z80901 Z80901 CHEMBL614392 HaCaT (Keratinocytes) 1
Z81000 Z81000 CHEMBL614316 HT-22 (Hippocampal Cells) 1
Z81011 Z81011 CHEMBL614840 Human Cell Lines 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1

Most Common Rings