UCSF

Nitric Oxide Synthase, Inducible, Human (702 Compounds)

Swissprot:
NOS2_HUMAN
Stitch:
NOS2_HUMAN
UniProt:
P35228
ChEMBL:
CHEMBL4481
Reactome:
REACT_23862
REACT_121256
PDB:
1NSI (DOCK)
2NSI (DOCK)
3E7G (DOCK)
3EJ8 (DOCK)
3HR4 (DOCK)
4NOS (DOCK)

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 702 81 18 26
Binding ≤ 1μM 451 42 12 20
Functional ≤ 10μM 47 3 1 2

Reactome Network (2)

Reactome ID Description Species
REACT_23862 Nitric oxide stimulates guanylate cyclase Homo sapiens
REACT_121256 Phagosomal maturation (early endosomal stage) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 375
NOS3_HUMAN P29474 CHEMBL4803 Nitric-oxide Synthase, Endothelial, Human 274

Phagosomal maturation (early endosomal stage)

Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 375
NOS3_HUMAN P29474 CHEMBL4803 Nitric-oxide Synthase, Endothelial, Human 274
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NOS2_MOUSE P29477 CHEMBL3464 Nitric Oxide Synthase, Inducible, Mouse 194 27 8 13
NOS2_RAT Q06518 CHEMBL3051 Nitric Oxide Synthase, Inducible, Rat 2 2 2 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 645 79 16 31
NOS3_HUMAN P29474 CHEMBL4803 Nitric-oxide Synthase, Endothelial, Human 302 50 14 18

Clustered By Gene (0)

Clustered By Organism (8)

Code Description Substances Purchasable Natural In Man
NOS2-1-E Nitric Oxide Synthase, Inducible (cluster #1 Of 9), Eukaryotic 152 9 1 0
NOS2-2-E Nitric Oxide Synthase, Inducible (cluster #2 Of 9), Eukaryotic 36 6 0 2
NOS2-3-E Nitric Oxide Synthase, Inducible (cluster #3 Of 9), Eukaryotic 71 7 1 2
NOS2-4-E Nitric Oxide Synthase, Inducible (cluster #4 Of 9), Eukaryotic 450 31 2 16
NOS2-5-E Nitric Oxide Synthase, Inducible (cluster #5 Of 9), Eukaryotic 43 5 2 1
NOS2-6-E Nitric Oxide Synthase, Inducible (cluster #6 Of 9), Eukaryotic 2 2 0 1
NOS2-7-E Nitric Oxide Synthase, Inducible (cluster #7 Of 9), Eukaryotic 54 18 11 11
NOS2-8-E Nitric Oxide Synthase, Inducible (cluster #8 Of 9), Eukaryotic 14 11 5 1
NOS2-9-E Nitric Oxide Synthase, Inducible (cluster #9 Of 9), Eukaryotic 34 7 1 0
Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 375
NOS3_HUMAN P29474 CHEMBL4803 Nitric-oxide Synthase, Endothelial, Human 274
NOS1_RAT P29476 CHEMBL3048 Nitric-oxide Synthase, Brain, Rat 87
NOS2_MOUSE P29477 CHEMBL3464 Nitric Oxide Synthase, Inducible, Mouse 57
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 11
NOS3_BOVIN P29473 CHEMBL4802 Nitric-oxide Synthase, Endothelial, Bovin 9
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 8
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 5
NOS3_PIG Q28969 CHEMBL3809 Nitric-oxide Synthase, Endothelial, Pig 4
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 3
NOS1_MOUSE Q9Z0J4 CHEMBL4719 Nitric-oxide Synthase, Brain, Mouse 2
A4_HUMAN P05067 CHEMBL2487 Beta Amyloid A4 Protein, Human 1
ABP1_HUMAN P19801 CHEMBL2118 Diamine Oxidase, Human 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH1_HUMAN P00915 CHEMBL261 Carbonic Anhydrase I, Human 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
DHB3_RAT O54939 CHEMBL1075158 Testosterone 17-beta-dehydrogenase 3, Rat 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1
LGUL_HUMAN Q04760 CHEMBL2424 Glyoxalase I, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
MMP9_HUMAN P14780 CHEMBL321 Matrix Metalloproteinase 9, Human 1
MTSI_SPISQ P15840 CHEMBL4373 CpG DNA Methylase, Spisq 1
NOS2_RAT Q06518 CHEMBL3051 Nitric Oxide Synthase, Inducible, Rat 1
NOS3_MOUSE P70313 CHEMBL2643 Nitric-oxide Synthase, Endothelial, Mouse 1
NOS3_RAT Q62600 CHEMBL1075230 Nitric Oxide Synthase, Endothelial, Rat 1
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 1
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 1
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 1
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
Q8HY88_BOVIN Q8HY88 CHEMBL1075183 Potassium Channel Subfamily K Member 2, Bovin 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1

Most Common Rings