UCSF

Nitric-oxide Synthase, Endothelial, Human (302 Compounds)

Swissprot:
NOS3_HUMAN
Stitch:
NOS3_HUMAN
UniProt:
P29474
ChEMBL:
CHEMBL4803
Reactome:
REACT_12477
REACT_23862
REACT_12510
REACT_12541
REACT_121256
REACT_111176
REACT_228016
PDB:
1M9J (DOCK)
1M9K (DOCK)
1M9M (DOCK)
1M9Q (DOCK)
1M9R (DOCK)
3EAH (DOCK)
3NOS (DOCK)
NOS3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 302 50 14 18
Binding ≤ 1μM 100 26 9 11
Functional ≤ 10μM 45 4 2 1

Reactome Network (7)

Reactome ID Description Species
REACT_12477 eNOS activation Homo sapiens
REACT_23862 Nitric oxide stimulates guanylate cyclase Homo sapiens
REACT_12510 NOSIP mediated eNOS trafficking Homo sapiens
REACT_12541 NOSTRIN mediated eNOS trafficking Homo sapiens
REACT_121256 Phagosomal maturation (early endosomal stage) Homo sapiens
REACT_111176 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Homo sapiens
REACT_228016 VEGFR2 mediated vascular permeability Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 274
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 274

Phagosomal maturation (early endosomal stage)

Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 274
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 274
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NOS3_BOVIN P29473 CHEMBL4802 Nitric-oxide Synthase, Endothelial, Bovin 41 7 4 5
NOS3_MOUSE P70313 CHEMBL2643 Nitric-oxide Synthase, Endothelial, Mouse 4 1 1 1
NOS3_PIG Q28969 CHEMBL3809 Nitric-oxide Synthase, Endothelial, Pig 8 0 0 2
NOS3_RAT Q62600 CHEMBL1075230 Nitric Oxide Synthase, Endothelial, Rat 5 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 645 79 16 31
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 702 81 18 26

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
NOS3-1-E Nitric Oxide Synthase, Endothelial (cluster #1 Of 7), Eukaryotic 109 20 9 8
NOS3-2-E Nitric Oxide Synthase, Endothelial (cluster #2 Of 7), Eukaryotic 109 1 0 7
NOS3-3-E Nitric Oxide Synthase, Endothelial (cluster #3 Of 7), Eukaryotic 80 10 0 3
NOS3-4-E Nitric Oxide Synthase, Endothelial (cluster #4 Of 7), Eukaryotic 2 1 1 1
NOS3-5-E Nitric Oxide Synthase, Endothelial (cluster #5 Of 7), Eukaryotic 5 4 0 2
NOS3-6-E Nitric Oxide Synthase, Endothelial (cluster #6 Of 7), Eukaryotic 23 18 6 2
NOS3-7-E Nitric Oxide Synthase, Endothelial (cluster #7 Of 7), Eukaryotic 16 1 0 0
Uniprot Swissprot Chembl Description Number Shared
NOS1_HUMAN P29475 CHEMBL3568 Nitric-oxide Synthase, Brain, Human 274
NOS2_HUMAN P35228 CHEMBL4481 Nitric Oxide Synthase, Inducible, Human 274
NOS1_RAT P29476 CHEMBL3048 Nitric-oxide Synthase, Brain, Rat 80
NOS2_MOUSE P29477 CHEMBL3464 Nitric Oxide Synthase, Inducible, Mouse 28
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 11
NOS3_BOVIN P29473 CHEMBL4802 Nitric-oxide Synthase, Endothelial, Bovin 8
NOS3_RAT Q62600 CHEMBL1075230 Nitric Oxide Synthase, Endothelial, Rat 5
NOS3_PIG Q28969 CHEMBL3809 Nitric-oxide Synthase, Endothelial, Pig 4
NOS1_MOUSE Q9Z0J4 CHEMBL4719 Nitric-oxide Synthase, Brain, Mouse 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
NOS2_RAT Q06518 CHEMBL3051 Nitric Oxide Synthase, Inducible, Rat 1
NOS3_MOUSE P70313 CHEMBL2643 Nitric-oxide Synthase, Endothelial, Mouse 1
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 1
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 1
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1

Most Common Rings