ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (847)
Reactome (4)
Related By:
Pathway (15)
Organism (2)
Gene (0)
Org. Clust. (1)
ChEMBL (53)
Rings (22)

Thromboxane A2 Receptor, Human (847 Compounds)

Swissprot:: TA2R_HUMAN
Stitch:: TA2R_HUMAN
UniProt:: P21731
ChEMBL:: CHEMBL2069
Reactome:: REACT_18407; REACT_18283; REACT_18425; REACT_20647
PDB:: 1LBN (DOCK); TBXA2R

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	847	19	7	11
Binding ≤ 1μM	694	13	6	10
Functional ≤ 10μM	301	11	7	9

Reactome ID	Description	Species
REACT_18407	G alpha (12/13) signalling events	Homo sapiens
REACT_18283	G alpha (q) signalling events	Homo sapiens
REACT_18425	Prostanoid ligand receptors	Homo sapiens
REACT_20647	Thromboxane signalling through TP receptor	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	24
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
NPSR1_HUMAN	Q6W5P4	CHEMBL5162	Neuropeptide S Receptor, Human	2
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	32
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	21

Prostanoid ligand receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
GPR44_HUMAN	Q9Y5Y4	CHEMBL5071	G Protein-coupled Receptor 44, Human	36
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	219
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	32
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	22
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	34
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	21
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	21
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	31

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
TA2R_MOUSE	P30987	CHEMBL1795181	Thromboxane A2 Receptor, Mouse	9	0	0	0
TA2R_RAT	P34978	CHEMBL3156	Thromboxane A2 Receptor, Rat	10	0	0	1

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
TA2R-1-E	Thromboxane A2 Receptor (cluster #1 Of 2), Eukaryotic	768	13	6	10
TA2R-2-E	Thromboxane A2 Receptor (cluster #2 Of 2), Eukaryotic	94	11	4	4

Uniprot	Swissprot	Chembl	Description	Number Shared
PD2R_HUMAN	Q13258	CHEMBL4427	Prostanoid DP Receptor, Human	218
Z50587	Z50587	CHEMBL372	Homo Sapiens	133
PGH2_HUMAN	P35354	CHEMBL230	Cyclooxygenase-2, Human	87
THAS_HUMAN	P24557	CHEMBL1835	Thromboxane-A Synthase, Human	74
THAS_RAT	P49430	CHEMBL4028	Thromboxane-A Synthase, Rat	57
GPR44_HUMAN	Q9Y5Y4	CHEMBL5071	G Protein-coupled Receptor 44, Human	36
TA2R_RAT	P34978	CHEMBL3156	Thromboxane A2 Receptor, Rat	33
PE2R1_HUMAN	P34995	CHEMBL1811	Prostanoid EP1 Receptor, Human	30
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	30
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	25
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	24
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	23
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	19
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	19
PF2R_HUMAN	P43088	CHEMBL1987	Prostanoid FP Receptor, Human	19
TA2R_MOUSE	P30987	CHEMBL1795181	Thromboxane A2 Receptor, Mouse	19
Z50512	Z50512	CHEMBL369	Cavia Porcellus	7
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	5
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	5
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	4
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	4
PF2R_MOUSE	P43117	CHEMBL5000	Prostaglandin F2-alpha Receptor, Mouse	3
Z81011	Z81011	CHEMBL614840	Human Cell Lines	3
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
PD2R_MOUSE	P70263	CHEMBL3933	Prostanoid DP Receptor, Mouse	2
PE2R1_RAT	P70597	CHEMBL5068	Prostanoid EP1 Receptor, Rat	2
PE2R2_MOUSE	Q62053	CHEMBL2488	Prostanoid EP2 Receptor, Mouse	2
PE2R3_MOUSE	P30557	CHEMBL4336	Prostanoid EP3 Receptor, Mouse	2
PE2R3_RAT	P34980	CHEMBL5674	Prostaglandin E2 Receptor EP3 Subtype, Rat	2
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	1
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	1
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	1
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	1
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	1
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	1
LOX5_HUMAN	P09917	CHEMBL215	Arachidonate 5-lipoxygenase, Human	1
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	1
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	1
PE2R1_MOUSE	P35375	CHEMBL2181	Prostanoid EP1 Receptor, Mouse	1
PE2R4_MOUSE	P32240	CHEMBL2489	Prostanoid EP4 Receptor, Mouse	1
PGH1_HUMAN	P23219	CHEMBL221	Cyclooxygenase-1, Human	1
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	1
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	1
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	1
Z50589	Z50589	CHEMBL612670	Felis Catus	1
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	1
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	1
Z80530	Z80530	CHEMBL614946	Swiss-3T3 (Fibroblast Cells)	1