ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (215)
Reactome (2)
Related By:
Pathway (19)
Organism (1)
Gene (4)
Org. Clust. (0)
ChEMBL (172)
Rings (21)

Dopamine D5 Receptor, Human (215 Compounds)

Swissprot:: DRD5_HUMAN
Stitch:: DRD5_HUMAN
UniProt:: P21918
ChEMBL:: CHEMBL1850
Reactome:: REACT_16968; REACT_19327
PDB:: DRD5

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	215	21	16	14
Binding ≤ 1μM	173	20	14	14
Functional ≤ 10μM	29	4	2	0

Reactome ID	Description	Species
REACT_16968	Dopamine receptors	Homo sapiens
REACT_19327	G alpha (s) signalling events	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	181
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	193
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	144
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	152

G alpha (s) signalling events

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	3
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	24
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	25
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY5_HUMAN	O95622	CHEMBL3189	Adenylate Cyclase Type V, Human	2
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	9
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	7
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	181
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	13
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	4
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	4
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	4

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	501	72	37	44

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	653	67	30	30
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	3,672	241	71	74
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	2,290	174	48	59
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	1,846	158	44	42

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	193
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	180
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	152
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	140
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	37
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	30
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	28
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	25
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	25
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	24
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	24
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	21
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	20
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	19
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	19
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	18
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	17
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	17
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	17
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	17
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	16
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	16
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	16
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	15
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	15
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	14
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	14
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	14
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	14
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	14
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	13
DRD1_PIG	P50130	CHEMBL5067	Dopamine D1 Receptor, Pig	13
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	13
5HT1B_HUMAN	P28222	CHEMBL1898	Serotonin 1b (5-HT1b) Receptor, Human	12
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	12
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	12
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	11
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	9
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	9
DRD1_MOUSE	Q61616	CHEMBL3071	Dopamine D1 Receptor, Mouse	9
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	9
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	8
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	8
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	8
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	8
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	8
SC6A4_MOUSE	Q60857	CHEMBL4642	Serotonin Transporter, Mouse	8
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	7
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	7
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	7
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	7
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	6
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	6
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	6
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	6
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	6
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	6
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	6
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	5
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	5
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	5
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	5
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	5
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	5
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	5
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	5
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	5
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	5
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	5
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	5
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	5
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	5
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	5
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	5
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	5
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	5
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	4
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	4
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	4
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	4
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	4
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	4
DRD2_MOUSE	P61168	CHEMBL3427	Dopamine D2 Receptor, Mouse	4
PE2R2_HUMAN	P43116	CHEMBL1881	Prostanoid EP2 Receptor, Human	4
PE2R3_HUMAN	P43115	CHEMBL3710	Prostanoid EP3 Receptor, Human	4
PE2R4_HUMAN	P35408	CHEMBL1836	Prostanoid EP4 Receptor, Human	4
PI2R_HUMAN	P43119	CHEMBL1995	Prostanoid IP Receptor, Human	4
TA2R_HUMAN	P21731	CHEMBL2069	Thromboxane A2 Receptor, Human	4
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	4
5HT1F_HUMAN	P30939	CHEMBL1805	Serotonin 1f (5-HT1f) Receptor, Human	3
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	3
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	3
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	3
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	3
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	3
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	3
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	3
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	3
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	3
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	3
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	3
PDR5_YEAST	P33302	CHEMBL1697658	Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast	3
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	3
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	2
5HT2A_MOUSE	P35363	CHEMBL5377	Serotonin 2a (5-HT2a) Receptor, Mouse	2
5HT2B_MOUSE	Q02152	CHEMBL2583	Serotonin 2b (5-HT2b) Receptor, Mouse	2
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	2
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) Receptor, Rat	2
5HT5A_RAT	P35364	CHEMBL4655	Serotonin 5a (5-HT5a) Receptor, Rat	2
5HT5B_RAT	P35365	CHEMBL2619	Serotonin 5b (5-HT5b) Receptor, Rat	2
5HT6R_RAT	P31388	CHEMBL3372	Serotonin 6 (5-HT6) Receptor, Rat	2
ACM3_RAT	P08483	CHEMBL320	Muscarinic Acetylcholine Receptor M3, Rat	2
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	2
ADCY5_HUMAN	O95622	CHEMBL3189	Adenylate Cyclase Type V, Human	2
ADRB1_RAT	P18090	CHEMBL3252	Beta-1 Adrenergic Receptor, Rat	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
DRD2_CHLAE	P52702	CHEMBL5456	Dopamine D2 Receptor, Chlae	2
GALR3_HUMAN	O60755	CHEMBL2731	Galanin Receptor 3, Human	2
MDR1_HUMAN	P08183	CHEMBL4302	P-glycoprotein 1, Human	2
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	2
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	2
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	2
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	2
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	1
5HT2A_PIG	P50129	CHEMBL2490	Serotonin 2a (5-HT2a) Receptor, Pig	1
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	1
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	1
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	1
5HT4R_CAVPO	O70528	CHEMBL5017	Serotonin 4 (5-HT4) Receptor, Guinea Pig	1
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	1
ACM4_RAT	P08485	CHEMBL317	Muscarinic Acetylcholine Receptor M4, Rat	1
ACM5_RAT	P08911	CHEMBL277	Muscarinic Acetylcholine Receptor M5, Rat	1
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
ADRB2_RAT	P10608	CHEMBL3754	Beta-2 Adrenergic Receptor, Rat	1
ADRB3_RAT	P26255	CHEMBL4031	Beta-3 Adrenergic Receptor, Rat	1
ANDR_RAT	P15207	CHEMBL3072	Androgen Receptor, Rat	1
AP2S1_RAT	P62744	CHEMBL1697667	AP-2 Complex Subunit Sigma, Rat	1
CALM_HUMAN	P62158	CHEMBL6093	Calmodulin, Human	1
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	1
EBP_HUMAN	Q15125	CHEMBL4931	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human	1
EPYC_HUMAN	Q99645	CHEMBL2080	Small Chondroitin/dermatan Sulfate Proteoglycan, Human	1
ERG2_YEAST	P32352	CHEMBL3224	C-8 Sterol Isomerase, Yeast	1
HRH1_CAVPO	P31389	CHEMBL3943	Histamine H1 Receptor, Guinea Pig	1
HRH2_RAT	P25102	CHEMBL4654	Histamine H2 Receptor, Rat	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	1
MTR1B_HUMAN	P49286	CHEMBL1946	Melatonin Receptor 1B, Human	1
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	1
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	1
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	1
NMDE2_HUMAN	Q13224	CHEMBL1904	Glutamate [NMDA] Receptor Subunit Epsilon 2, Human	1
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	1
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	1
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	1
PRIO_HUMAN	P04156	CHEMBL4869	Prion Protein, Human	1
Q4U254_9ENTO	Q4U254	CHEMBL2857	Human Rhinovirus A Protease, 9ento	1
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	1
SC6A3_BOVIN	P27922	CHEMBL2986	Dopamine Transporter, Bovin	1
SC6A3_MACFA	Q9GJT6	CHEMBL5032	Dopamine Transporter, Macfa	1
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	1
TRPV1_RAT	O35433	CHEMBL5102	Vanilloid Receptor, Rat	1
TSPOB_HUMAN	B1AH88	CHEMBL5139	Peripheral-type Benzodiazepine Receptor, Human	1
TYTR_TRYCR	P28593	CHEMBL5131	Trypanothione Reductase, Trycr	1
Z100251	Z100251	CHEMBL612442	Monoclonal Antibody (mAb) 2E2	1
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	1
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	1
Z50796	Z50796	CHEMBL614874	Monkey	1