UCSF

AP-2 Complex Subunit Sigma, Rat (10 Compounds)

Swissprot:
AP2S1_RAT
Stitch:
AP2S1_RAT
UniProt:
P62744
ChEMBL:
CHEMBL1697667
Reactome:
REACT_241654
REACT_198830
REACT_262886
REACT_235514
REACT_252925
REACT_198398
PDB:
Ap2s1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 10 1 1 1
Binding ≤ 1μM 4 1 1 1

Reactome Network (6)

Reactome ID Description Species
REACT_241654 EGFR downregulation Rattus norvegicus
REACT_198830 MHC class II antigen presentation Rattus norvegicus
REACT_262886 Recycling pathway of L1 Rattus norvegicus
REACT_235514 Retrograde neurotrophin signalling Rattus norvegicus
REACT_252925 Trafficking of GluR2-containing AMPA receptors Rattus norvegicus
REACT_198398 WNT5A-dependent internalization of FZD4 Rattus norvegicus

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 10
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 10
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 10
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 9
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 1
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 1
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 1
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 1
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 1
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 1
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 1
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 1
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 1
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 1
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 1
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 1
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 1
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 1
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 1
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 1
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 1
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 1
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 1
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 1
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 1
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 1
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 1
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 1
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 1
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 1
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 1
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 1
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 1
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 1
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 1

Most Common Rings