UCSF

Dopamine D1 Receptor, Bovin (223 Compounds)

Swissprot:
DRD1_BOVIN
Stitch:
DRD1_BOVIN
UniProt:
Q95136
ChEMBL:
CHEMBL2967
Reactome:
REACT_213578
REACT_206547
PDB:
DRD1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 223 30 11 15
Binding ≤ 1μM 117 21 9 13
Functional ≤ 10μM 8 5 2 2

Reactome Network (2)

Reactome ID Description Species
REACT_213578 Dopamine receptors Bos taurus
REACT_206547 G alpha (s) signalling events Bos taurus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 653 67 30 30
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 19 4 2 4
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 169 16 5 5
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 1,231 142 69 68
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 425 51 18 25

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
DRD1-1-E Dopamine D1 Receptor (cluster #1 Of 4), Eukaryotic 1,944 200 85 86
DRD1-2-E Dopamine D1 Receptor (cluster #2 Of 4), Eukaryotic 281 18 5 8
DRD1-3-E Dopamine D1 Receptor (cluster #3 Of 4), Eukaryotic 1 1 1 1
DRD1-4-E Dopamine D1 Receptor (cluster #4 Of 4), Eukaryotic 4 2 1 1
Uniprot Swissprot Chembl Description Number Shared
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 156
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 147
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 134
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 98
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 29
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 25
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 24
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 23
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 22
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 22
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 15
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 14
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 14
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 14
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 14
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 14
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 14
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 13
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 13
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 13
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 11
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 10
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 9
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 9
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 9
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 9
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 8
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 8
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 8
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 8
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 7
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 7
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 6
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 6
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 6
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 5
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 5
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 5
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 5
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 5
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 5
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 5
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 4
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 4
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 4
EPYC_HUMAN Q99645 CHEMBL2080 Small Chondroitin/dermatan Sulfate Proteoglycan, Human 4
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 3
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 3
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 3
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 3
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 3
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 3
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 3
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 3
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 3
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 3
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 3
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 3
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 3
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 3
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 3
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 3
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 3
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 3
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 3
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 3
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 2
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 2
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 2
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 2
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 2
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 2
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 2
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 2
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 2
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 2
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 2
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 2
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 1
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 1
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 1
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 1
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 1
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 1
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 1
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 1
ACES_TORCA P04058 CHEMBL4780 Acetylcholinesterase, Torca 1
ACM3_RAT P08483 CHEMBL320 Muscarinic Acetylcholine Receptor M3, Rat 1
ACM4_RAT P08485 CHEMBL317 Muscarinic Acetylcholine Receptor M4, Rat 1
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 1
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 1
AP2S1_RAT P62744 CHEMBL1697667 AP-2 Complex Subunit Sigma, Rat 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 1
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 1
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 1
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 1
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
PCP_HUMAN P42785 CHEMBL2335 Lysosomal Pro-X Carboxypeptidase, Human 1
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TY3H_HUMAN P07101 CHEMBL1969 Tyrosine 3-hydroxylase, Human 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1

Most Common Rings