UCSF

Glutamate [NMDA] Receptor Subunit Epsilon 2, Human (437 Compounds)

Swissprot:
NMDE2_HUMAN
Stitch:
NMDE2_HUMAN
UniProt:
Q13224
ChEMBL:
CHEMBL1904
Reactome:
REACT_20642
REACT_228085
REACT_20546
REACT_20594
PDB:
1S11 (DOCK)
1S2S (DOCK)
2IPV (DOCK)
GRIN2B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 437 60 22 20
Binding ≤ 1μM 313 39 15 15
Functional ≤ 10μM 51 2 1 1
Uniprot Swissprot Chembl Description Number Shared
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 358
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 358
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 358
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 358

EPHB-mediated forward signaling

Uniprot Swissprot Chembl Description Number Shared
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 358

Ras activation uopn Ca2+ infux through NMDA receptor

Uniprot Swissprot Chembl Description Number Shared
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 358
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 358
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 358
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 358

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 3
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 3
GRIA3_HUMAN P42263 CHEMBL3595 Glutamate Receptor Ionotropic, AMPA 3, Human 3
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 3
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 358
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 358
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 358
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 358
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NMDE2_MOUSE Q01097 CHEMBL3442 Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse 16 7 4 3
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 473 39 15 17
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 358 58 22 20
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 358 58 22 20
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 358 58 22 20

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
NMDE2-1-E Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #1 Of 5), Eukaryotic 622 48 20 25
NMDE2-2-E Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #2 Of 5), Eukaryotic 33 6 1 2
NMDE2-3-E Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #3 Of 5), Eukaryotic 89 10 2 1
NMDE2-4-E Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #4 Of 5), Eukaryotic 44 17 7 3
NMDE2-5-E Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #5 Of 5), Eukaryotic 83 8 2 1
Uniprot Swissprot Chembl Description Number Shared
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 358
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 358
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 358
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 358
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 358
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 356
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 91
NMDZ1_RAT P35439 CHEMBL330 Glutamate (NMDA) Receptor Subunit Zeta 1, Rat 89
GRID1_HUMAN Q9ULK0 CHEMBL2936 Glutamate Receptor Delta-1 Subunit, Human 62
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 56
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 54
Z104297 Z104297 CHEMBL1907603 Glutamate NMDA Receptor; GRIN1/GRIN2B 52
GRINA_HUMAN Q7Z429 CHEMBL4704 Glutamate [NMDA] Receptor Associated Protein 1, Human 40
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 38
Z104298 Z104298 CHEMBL1907604 Glutamate NMDA Receptor; GRIN1/GRIN2A 38
NMDE1_RAT Q00959 CHEMBL310 Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat 37
NMD3A_RAT Q9R1M7 CHEMBL342 Glutamate [NMDA] Receptor Subunit 3A, Rat 36
NMD3B_RAT Q8VHN2 CHEMBL282 Glutamate [NMDA] Receptor Subunit 3B, Rat 36
NMDE4_RAT Q62645 CHEMBL303 Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat 36
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 29
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 28
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 28
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 11
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 8
A2AIR5_MOUSE A2AIR5 CHEMBL2562 Glutamate [NMDA] Receptor Subunit 3A, Mouse 6
NMD3B_MOUSE Q91ZU9 CHEMBL2557 Glutamate [NMDA] Receptor Subunit 3B, Mouse 6
NMDE1_MOUSE P35436 CHEMBL2521 Glutamate [NMDA] Receptor Subunit Epsilon 1, Mouse 6
NMDE2_MOUSE Q01097 CHEMBL3442 Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse 6
NMDE3_MOUSE Q01098 CHEMBL3555 Glutamate [NMDA] Receptor Subunit Epsilon 3, Mouse 6
NMDE4_MOUSE Q03391 CHEMBL2893 Glutamate [NMDA] Receptor Subunit Epsilon 4, Mouse 6
NMDZ1_MOUSE P35438 CHEMBL2895 Glutamate (NMDA) Receptor Subunit Zeta 1, Mouse 6
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 6
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 5
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 5
GRIA2_RAT P19491 CHEMBL3503 Glutamate Receptor Ionotropic, AMPA 2, Rat 5
GRIA3_RAT P19492 CHEMBL3504 Glutamate Receptor Ionotropic, AMPA 3, Rat 5
GRIA4_RAT P19493 CHEMBL3505 Glutamate Receptor Ionotropic, AMPA 4, Rat 5
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 5
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 3
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 3
GRIA3_HUMAN P42263 CHEMBL3595 Glutamate Receptor Ionotropic, AMPA 3, Human 3
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
OPRD_MOUSE P32300 CHEMBL3222 Delta Opioid Receptor, Mouse 2
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 2
OPRK_MOUSE P33534 CHEMBL4329 Kappa Opioid Receptor, Mouse 2
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 2
OPRM_MOUSE P42866 CHEMBL2858 Mu Opioid Receptor, Mouse 2
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 2
PCP_HUMAN P42785 CHEMBL2335 Lysosomal Pro-X Carboxypeptidase, Human 2
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 2
SGMR1_MOUSE O55242 CHEMBL3465 Sigma Opioid Receptor, Mouse 2
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 1
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 1
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 1
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 1
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 1
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 1
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 1
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 1
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 1
ACM3_MOUSE Q9ERZ3 CHEMBL5105 Muscarinic Acetylcholine Receptor M3, Mouse 1
ACM4_MOUSE P32211 CHEMBL4572 Muscarinic Acetylcholine Receptor M4, Mouse 1
ACM5_MOUSE Q920H4 CHEMBL2324 Muscarinic Acetylcholine Receptor M5, Mouse 1
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
CALM_HUMAN P62158 CHEMBL6093 Calmodulin, Human 1
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 1
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 1
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 1
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 1
EBP_CAVPO Q60490 CHEMBL5525 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Guinea Pig 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
GLRA1_RAT P07727 CHEMBL3246 Glycine Receptor Alpha-1 Chain, Rat 1
GLRA2_RAT P22771 CHEMBL2328 Glycine Receptor Alpha-2 Chain, Rat 1
GLRA3_RAT P24524 CHEMBL2677 Glycine Receptor Alpha-3 Chain, Rat 1
GLRB_RAT P20781 CHEMBL4126 Glycine Receptor Beta Chain, Rat 1
GRIA1_RAT P19490 CHEMBL3753 Glutamate Receptor Ionotropic, AMPA 1, Rat 1
GRIK1_HUMAN P39086 CHEMBL1918 Glutamate Receptor Ionotropic Kainate 1, Human 1
GRIK1_RAT P22756 CHEMBL2919 Glutamate Receptor Ionotropic Kainate 1, Rat 1
GRIK2_HUMAN Q13002 CHEMBL3683 Glutamate Receptor Ionotropic Kainate 2, Human 1
GRIK2_RAT P42260 CHEMBL3607 Glutamate Receptor Ionotropic Kainate 2, Rat 1
GRIK3_HUMAN Q13003 CHEMBL3684 Glutamate Receptor Ionotropic Kainate 3, Human 1
GRIK3_RAT P42264 CHEMBL3744 Glutamate Receptor Ionotropic Kainate 3, Rat 1
GRIK4_HUMAN Q16099 CHEMBL2829 Glutamate Receptor Ionotropic Kainate 4, Human 1
GRIK4_RAT Q01812 CHEMBL3044 Glutamate Receptor Ionotropic Kainate 4, Rat 1
GRIK5_HUMAN Q16478 CHEMBL2675 Glutamate Receptor Ionotropic Kainate 5, Human 1
GRIK5_RAT Q63273 CHEMBL4041 Glutamate Receptor Ionotropic Kainate 5, Rat 1
GRL1A_RAT Q91XQ4 CHEMBL3059 Glutamate [NMDA] Receptor-like 1A, Rat 1
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_CAVPO P97266 CHEMBL4354 Mu Opioid Receptor, Guinea Pig 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
PDR5_YEAST P33302 CHEMBL1697658 Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast 1
PRIO_HUMAN P04156 CHEMBL4869 Prion Protein, Human 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN1A_RAT P04774 CHEMBL4906 Sodium Channel Protein Type I Alpha Subunit, Rat 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN3A_RAT P08104 CHEMBL4966 Sodium Channel Protein Type III Alpha Subunit, Rat 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 1
THRB_HUMAN P00734 CHEMBL204 Thrombin, Human 1
TRPV1_RAT O35433 CHEMBL5102 Vanilloid Receptor, Rat 1
TYTR_TRYCR P28593 CHEMBL5131 Trypanothione Reductase, Trycr 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1