ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (437)
Reactome (4)
Related By:
Pathway (13)
Organism (2)
Gene (3)
Org. Clust. (4)
ChEMBL (137)
Rings (8)

Glutamate [NMDA] Receptor Subunit Epsilon 2, Human (437 Compounds)

Swissprot:: NMDE2_HUMAN
Stitch:: NMDE2_HUMAN
UniProt:: Q13224
ChEMBL:: CHEMBL1904
Reactome:: REACT_20642; REACT_228085; REACT_20546; REACT_20594
PDB:: 1S11 (DOCK); 1S2S (DOCK); 2IPV (DOCK); GRIN2B

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	437	60	22	20
Binding ≤ 1μM	313	39	15	15
Functional ≤ 10μM	51	2	1	1

Reactome ID	Description	Species
REACT_20642	CREB phosphorylation through the activation of CaMKII	Homo sapiens
REACT_228085	EPHB-mediated forward signaling	Homo sapiens
REACT_20546	Ras activation uopn Ca2+ infux through NMDA receptor	Homo sapiens
REACT_20594	Unblocking of NMDA receptor, glutamate binding and activation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
CALM_HUMAN	P62158	CHEMBL6093	Calmodulin, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	358
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	358
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	358
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	358

EPHB-mediated forward signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	358

Ras activation uopn Ca2+ infux through NMDA receptor

Uniprot	Swissprot	Chembl	Description	Number Shared
CALM_HUMAN	P62158	CHEMBL6093	Calmodulin, Human	1
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	358
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	358
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	358
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	358

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot	Swissprot	Chembl	Description	Number Shared
GRIA1_HUMAN	P42261	CHEMBL2009	Glutamate Receptor Ionotropic, AMPA 1, Human	3
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	3
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	3
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	3
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	358
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	358
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	358
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	358

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
NMDE2_MOUSE	Q01097	CHEMBL3442	Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse	16	7	4	3
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	473	39	15	17

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	358	58	22	20
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	358	58	22	20
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	358	58	22	20

Clustered By Gene (0)

Clustered By Organism (4)

Code	Description	Substances	Purchasable	Natural	In Man
NMDE2-1-E	Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #1 Of 5), Eukaryotic	622	48	20	25
NMDE2-2-E	Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #2 Of 5), Eukaryotic	33	6	1	2
NMDE2-3-E	Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #3 Of 5), Eukaryotic	89	10	2	1
NMDE2-4-E	Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #4 Of 5), Eukaryotic	44	17	7	3
NMDE2-5-E	Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #5 Of 5), Eukaryotic	83	8	2	1

Uniprot	Swissprot	Chembl	Description	Number Shared
NMD3B_HUMAN	O60391	CHEMBL2913	Glutamate [NMDA] Receptor Subunit 3B, Human	358
NMDE1_HUMAN	Q12879	CHEMBL1972	Glutamate [NMDA] Receptor Subunit Epsilon 1, Human	358
NMDE3_HUMAN	Q14957	CHEMBL4109	Glutamate [NMDA] Receptor Subunit Epsilon 3, Human	358
NMDE4_HUMAN	O15399	CHEMBL2591	Glutamate [NMDA] Receptor Subunit Epsilon 4, Human	358
NMDZ1_HUMAN	Q05586	CHEMBL2015	Glutamate (NMDA) Receptor Subunit Zeta 1, Human	358
NMD3A_HUMAN	Q8TCU5	CHEMBL4787	Glutamate [NMDA] Receptor Subunit 3A, Human	356
Z104302	Z104302	CHEMBL1907608	Glutamate NMDA Receptor	91
NMDZ1_RAT	P35439	CHEMBL330	Glutamate (NMDA) Receptor Subunit Zeta 1, Rat	89
GRID1_HUMAN	Q9ULK0	CHEMBL2936	Glutamate Receptor Delta-1 Subunit, Human	62
NMDE2_RAT	Q00960	CHEMBL311	Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat	56
NMDE3_RAT	Q00961	CHEMBL401	Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat	54
Z104297	Z104297	CHEMBL1907603	Glutamate NMDA Receptor; GRIN1/GRIN2B	52
GRINA_HUMAN	Q7Z429	CHEMBL4704	Glutamate [NMDA] Receptor Associated Protein 1, Human	40
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	38
Z104298	Z104298	CHEMBL1907604	Glutamate NMDA Receptor; GRIN1/GRIN2A	38
NMDE1_RAT	Q00959	CHEMBL310	Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat	37
NMD3A_RAT	Q9R1M7	CHEMBL342	Glutamate [NMDA] Receptor Subunit 3A, Rat	36
NMD3B_RAT	Q8VHN2	CHEMBL282	Glutamate [NMDA] Receptor Subunit 3B, Rat	36
NMDE4_RAT	Q62645	CHEMBL303	Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat	36
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	29
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	28
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	28
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	11
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	8
A2AIR5_MOUSE	A2AIR5	CHEMBL2562	Glutamate [NMDA] Receptor Subunit 3A, Mouse	6
NMD3B_MOUSE	Q91ZU9	CHEMBL2557	Glutamate [NMDA] Receptor Subunit 3B, Mouse	6
NMDE1_MOUSE	P35436	CHEMBL2521	Glutamate [NMDA] Receptor Subunit Epsilon 1, Mouse	6
NMDE2_MOUSE	Q01097	CHEMBL3442	Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse	6
NMDE3_MOUSE	Q01098	CHEMBL3555	Glutamate [NMDA] Receptor Subunit Epsilon 3, Mouse	6
NMDE4_MOUSE	Q03391	CHEMBL2893	Glutamate [NMDA] Receptor Subunit Epsilon 4, Mouse	6
NMDZ1_MOUSE	P35438	CHEMBL2895	Glutamate (NMDA) Receptor Subunit Zeta 1, Mouse	6
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	6
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	5
GRIA1_MOUSE	P23818	CHEMBL3502	Glutamate Receptor Ionotropic, AMPA 1, Mouse	5
GRIA2_RAT	P19491	CHEMBL3503	Glutamate Receptor Ionotropic, AMPA 2, Rat	5
GRIA3_RAT	P19492	CHEMBL3504	Glutamate Receptor Ionotropic, AMPA 3, Rat	5
GRIA4_RAT	P19493	CHEMBL3505	Glutamate Receptor Ionotropic, AMPA 4, Rat	5
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	5
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	4
GRIA1_HUMAN	P42261	CHEMBL2009	Glutamate Receptor Ionotropic, AMPA 1, Human	3
GRIA2_HUMAN	P42262	CHEMBL4016	Glutamate Receptor Ionotropic, AMPA 2, Human	3
GRIA3_HUMAN	P42263	CHEMBL3595	Glutamate Receptor Ionotropic, AMPA 3, Human	3
GRIA4_HUMAN	P48058	CHEMBL3190	Glutamate Receptor Ionotropic, AMPA 4, Human	3
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	2
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	2
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	2
OPRD_MOUSE	P32300	CHEMBL3222	Delta Opioid Receptor, Mouse	2
OPRD_RAT	P33533	CHEMBL269	Delta Opioid Receptor, Rat	2
OPRK_MOUSE	P33534	CHEMBL4329	Kappa Opioid Receptor, Mouse	2
OPRK_RAT	P34975	CHEMBL3614	Kappa Opioid Receptor, Rat	2
OPRM_MOUSE	P42866	CHEMBL2858	Mu Opioid Receptor, Mouse	2
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	2
PCP_HUMAN	P42785	CHEMBL2335	Lysosomal Pro-X Carboxypeptidase, Human	2
SGMR1_CAVPO	Q60492	CHEMBL4153	Sigma-1 Receptor, Guinea Pig	2
SGMR1_MOUSE	O55242	CHEMBL3465	Sigma Opioid Receptor, Mouse	2
Z100491	Z100491	CHEMBL613288	Sigma 2 Receptor	2
Z50594	Z50594	CHEMBL375	Mus Musculus	2
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	1
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	1
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	1
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	1
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	1
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	1
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	1
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	1
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	1
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	1
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	1
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	1
ACM1_MOUSE	P12657	CHEMBL3733	Muscarinic Acetylcholine Receptor M1, Mouse	1
ACM1_RAT	P08482	CHEMBL276	Muscarinic Acetylcholine Receptor M1, Rat	1
ACM2_MOUSE	Q9ERZ4	CHEMBL3197	Muscarinic Acetylcholine Receptor M2, Mouse	1
ACM2_RAT	P10980	CHEMBL309	Muscarinic Acetylcholine Receptor M2, Rat	1
ACM3_MOUSE	Q9ERZ3	CHEMBL5105	Muscarinic Acetylcholine Receptor M3, Mouse	1
ACM4_MOUSE	P32211	CHEMBL4572	Muscarinic Acetylcholine Receptor M4, Mouse	1
ACM5_MOUSE	Q920H4	CHEMBL2324	Muscarinic Acetylcholine Receptor M5, Mouse	1
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	1
ADCY2_RAT	P26769	CHEMBL2958	Adenylate Cyclase Type II, Rat	1
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	1
ADCY4_RAT	P26770	CHEMBL2879	Adenylate Cyclase Type IV, Rat	1
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	1
ADCY6_RAT	Q03343	CHEMBL2975	Adenylate Cyclase Type VI, Rat	1
ADCY8_RAT	P40146	CHEMBL3082	Adenylate Cyclase Type VIII, Rat	1
CALM_HUMAN	P62158	CHEMBL6093	Calmodulin, Human	1
CHLE_MOUSE	Q03311	CHEMBL2528	Butyrylcholinesterase, Mouse	1
D4A3N4_RAT	D4A3N4	CHEMBL2679	Brain Adenylate Cyclase 1, Rat	1
DRD1_BOVIN	Q95136	CHEMBL2967	Dopamine D1 Receptor, Bovin	1
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	1
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	1
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	1
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	1
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	1
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	1
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	1
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	1
DRD5_RAT	P25115	CHEMBL2281	Dopamine D5 Receptor, Rat	1
EBP_CAVPO	Q60490	CHEMBL5525	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Guinea Pig	1
EBP_HUMAN	Q15125	CHEMBL4931	3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human	1
ERG2_YEAST	P32352	CHEMBL3224	C-8 Sterol Isomerase, Yeast	1
GLRA1_RAT	P07727	CHEMBL3246	Glycine Receptor Alpha-1 Chain, Rat	1
GLRA2_RAT	P22771	CHEMBL2328	Glycine Receptor Alpha-2 Chain, Rat	1
GLRA3_RAT	P24524	CHEMBL2677	Glycine Receptor Alpha-3 Chain, Rat	1
GLRB_RAT	P20781	CHEMBL4126	Glycine Receptor Beta Chain, Rat	1
GRIA1_RAT	P19490	CHEMBL3753	Glutamate Receptor Ionotropic, AMPA 1, Rat	1
GRIK1_HUMAN	P39086	CHEMBL1918	Glutamate Receptor Ionotropic Kainate 1, Human	1
GRIK1_RAT	P22756	CHEMBL2919	Glutamate Receptor Ionotropic Kainate 1, Rat	1
GRIK2_HUMAN	Q13002	CHEMBL3683	Glutamate Receptor Ionotropic Kainate 2, Human	1
GRIK2_RAT	P42260	CHEMBL3607	Glutamate Receptor Ionotropic Kainate 2, Rat	1
GRIK3_HUMAN	Q13003	CHEMBL3684	Glutamate Receptor Ionotropic Kainate 3, Human	1
GRIK3_RAT	P42264	CHEMBL3744	Glutamate Receptor Ionotropic Kainate 3, Rat	1
GRIK4_HUMAN	Q16099	CHEMBL2829	Glutamate Receptor Ionotropic Kainate 4, Human	1
GRIK4_RAT	Q01812	CHEMBL3044	Glutamate Receptor Ionotropic Kainate 4, Rat	1
GRIK5_HUMAN	Q16478	CHEMBL2675	Glutamate Receptor Ionotropic Kainate 5, Human	1
GRIK5_RAT	Q63273	CHEMBL4041	Glutamate Receptor Ionotropic Kainate 5, Rat	1
GRL1A_RAT	Q91XQ4	CHEMBL3059	Glutamate [NMDA] Receptor-like 1A, Rat	1
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	1
MDR1_HUMAN	P08183	CHEMBL4302	P-glycoprotein 1, Human	1
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	1
OPRK_CAVPO	P41144	CHEMBL3952	Kappa Opioid Receptor, Guinea Pig	1
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	1
OPRM_CAVPO	P97266	CHEMBL4354	Mu Opioid Receptor, Guinea Pig	1
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	1
PDR5_YEAST	P33302	CHEMBL1697658	Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast	1
PRIO_HUMAN	P04156	CHEMBL4869	Prion Protein, Human	1
Q8CFM9_RAT	Q8CFM9	CHEMBL3940	Adenylate Cyclase Type VII, Rat	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN1A_RAT	P04774	CHEMBL4906	Sodium Channel Protein Type I Alpha Subunit, Rat	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN2A_RAT	P04775	CHEMBL3399	Sodium Channel Protein Type II Alpha Subunit, Rat	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN3A_RAT	P08104	CHEMBL4966	Sodium Channel Protein Type III Alpha Subunit, Rat	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
SCN8A_RAT	O88420	CHEMBL2752	Sodium Channel Protein Type VIII Alpha Subunit, Rat	1
THRB_HUMAN	P00734	CHEMBL204	Thrombin, Human	1
TRPV1_RAT	O35433	CHEMBL5102	Vanilloid Receptor, Rat	1
TYTR_TRYCR	P28593	CHEMBL5131	Trypanothione Reductase, Trycr	1
Z104303	Z104303	CHEMBL1907609	Muscarinic Acetylcholine Receptor	1