UCSF

Glutamate Receptor Ionotropic, AMPA 3, Human (100 Compounds)

Swissprot:
GRIA3_HUMAN
Stitch:
GRIA3_HUMAN
UniProt:
P42263
ChEMBL:
CHEMBL3595
Reactome:
REACT_18338
REACT_18307
REACT_18422
REACT_20594
PDB:
GRIA3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 100 11 8 6
Binding ≤ 1μM 62 6 6 3
Functional ≤ 10μM 3 2 3 1

Reactome Network (4)

Reactome ID Description Species
REACT_18338 Activation of AMPA receptors Homo sapiens
REACT_18307 Trafficking of AMPA receptors Homo sapiens
REACT_18422 Trafficking of GluR2-containing AMPA receptors Homo sapiens
REACT_20594 Unblocking of NMDA receptor, glutamate binding and activation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 99
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 96
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 97

Trafficking of AMPA receptors

Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 99
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 97

Trafficking of GluR2-containing AMPA receptors

Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 99
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 96
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 97

Unblocking of NMDA receptor, glutamate binding and activation

Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 99
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 96
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 97
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 3
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 3
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 3
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 3
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 25 5 4 3
GRIA3_RAT P19492 CHEMBL3504 Glutamate Receptor Ionotropic, AMPA 3, Rat 666 37 21 25
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 161 19 11 13
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 150 18 9 10
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 122 18 13 13

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
GRIA3-1-E Glutamate Receptor Ionotropic, AMPA 3 (cluster #1 Of 4), Eukaryotic 648 18 11 6
GRIA3-2-E Glutamate Receptor Ionotropic, AMPA 3 (cluster #2 Of 4), Eukaryotic 13 4 1 1
GRIA3-3-E Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic 49 4 5 4
GRIA3-4-E Glutamate Receptor Ionotropic, AMPA 3 (cluster #4 Of 4), Eukaryotic 51 18 9 18
Uniprot Swissprot Chembl Description Number Shared
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 99
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 96
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 96
GRIK1_HUMAN P39086 CHEMBL1918 Glutamate Receptor Ionotropic Kainate 1, Human 33
GRIA3_RAT P19492 CHEMBL3504 Glutamate Receptor Ionotropic, AMPA 3, Rat 31
GRIA2_RAT P19491 CHEMBL3503 Glutamate Receptor Ionotropic, AMPA 2, Rat 30
GRIK5_HUMAN Q16478 CHEMBL2675 Glutamate Receptor Ionotropic Kainate 5, Human 29
GRIA4_RAT P19493 CHEMBL3505 Glutamate Receptor Ionotropic, AMPA 4, Rat 28
GRIK2_HUMAN Q13002 CHEMBL3683 Glutamate Receptor Ionotropic Kainate 2, Human 26
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 25
GRIK4_HUMAN Q16099 CHEMBL2829 Glutamate Receptor Ionotropic Kainate 4, Human 25
GRIK3_HUMAN Q13003 CHEMBL3684 Glutamate Receptor Ionotropic Kainate 3, Human 24
GRIK1_RAT P22756 CHEMBL2919 Glutamate Receptor Ionotropic Kainate 1, Rat 20
GRIA1_RAT P19490 CHEMBL3753 Glutamate Receptor Ionotropic, AMPA 1, Rat 19
GRIK2_RAT P42260 CHEMBL3607 Glutamate Receptor Ionotropic Kainate 2, Rat 13
GRIK3_RAT P42264 CHEMBL3744 Glutamate Receptor Ionotropic Kainate 3, Rat 13
GRIK4_RAT Q01812 CHEMBL3044 Glutamate Receptor Ionotropic Kainate 4, Rat 12
GRIK5_RAT Q63273 CHEMBL4041 Glutamate Receptor Ionotropic Kainate 5, Rat 12
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 12
NMDZ1_RAT P35439 CHEMBL330 Glutamate (NMDA) Receptor Subunit Zeta 1, Rat 10
GRIA2_MOUSE P23819 CHEMBL3205 Glutamate Receptor Ionotropic, AMPA 2, Mouse 7
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 7
GRIA4_MOUSE Q9Z2W8 CHEMBL3615 Glutamate Receptor Ionotropic, AMPA 4, Mouse 7
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 5
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 3
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 3
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 3
NMDE1_RAT Q00959 CHEMBL310 Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat 3
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 3
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 3
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
NMD3A_RAT Q9R1M7 CHEMBL342 Glutamate [NMDA] Receptor Subunit 3A, Rat 2
NMD3B_RAT Q8VHN2 CHEMBL282 Glutamate [NMDA] Receptor Subunit 3B, Rat 2
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 2
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 2
NMDE4_RAT Q62645 CHEMBL303 Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat 2
GLRA1_RAT P07727 CHEMBL3246 Glycine Receptor Alpha-1 Chain, Rat 1
GLRA2_RAT P22771 CHEMBL2328 Glycine Receptor Alpha-2 Chain, Rat 1
GLRA3_RAT P24524 CHEMBL2677 Glycine Receptor Alpha-3 Chain, Rat 1
GLRA4_MOUSE Q61603 CHEMBL3500 Glycine Receptor Alpha-4 Chain, Mouse 1
GLRB_RAT P20781 CHEMBL4126 Glycine Receptor Beta Chain, Rat 1
GRIK2_XENLA Q91755 CHEMBL3395 Glutamate Receptor Ionotropic Kainate 2, Xenla 1
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 1
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 1
GRM2_HUMAN Q14416 CHEMBL5137 Metabotropic Glutamate Receptor 2, Human 1
GRM2_RAT P31421 CHEMBL2851 Metabotropic Glutamate Receptor 2, Rat 1
GRM3_HUMAN Q14832 CHEMBL2888 Metabotropic Glutamate Receptor 3, Human 1
GRM3_RAT P31422 CHEMBL3067 Metabotropic Glutamate Receptor 3, Rat 1
GRM4_RAT P31423 CHEMBL2787 Metabotropic Glutamate Receptor 4, Rat 1
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 1
GRM6_RAT P35349 CHEMBL3842 Metabotropic Glutamate Receptor 6, Rat 1
GRM8_HUMAN O00222 CHEMBL3228 Metabotropic Glutamate Receptor 8, Human 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1

Most Common Rings